Title:
4-PYRIMIDINEDIAMINE SMALL MOLECULAR ORGANIC COMPOUNDS AND DERIVATIVES THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/219281
Kind Code:
A1
Abstract:
Disclosed is a class of 4-pyrimidinediamine small molecular organic compounds or related analogues or pharmaceutically acceptable salts thereof, with the structures thereof as shown in formulae (I)-(VI). Also disclosed are the use of the 4-pyrimidinediamine small molecular organic compounds or pharmaceutical compositions thereof in the preparation of drugs for preventing and/or treating various malignant tumours, autoimmune diseases, inflammation, etc., and the use of same as an inhibitor of B cell lymphokine 6 (BCL6) in the preparation of a drug for preventing and/or treating BCL6-mediated diseases.
Inventors:
CHEN YIHUA (CN)
LIU MINGYAO (CN)
GUO WEIKAI (CN)
XING YAJING (CN)
HUANG DONGXIA (CN)
YI ZHENGFANG (CN)
DU BING (CN)
ZHANG QIANSEN (CN)
LIU MINGYAO (CN)
GUO WEIKAI (CN)
XING YAJING (CN)
HUANG DONGXIA (CN)
YI ZHENGFANG (CN)
DU BING (CN)
ZHANG QIANSEN (CN)
Application Number:
PCT/CN2018/088932
Publication Date:
December 06, 2018
Filing Date:
May 30, 2018
Export Citation:
Assignee:
UNIV EAST CHINA NORMAL (CN)
BIORAY LABORATORIES INC (CN)
BIORAY LABORATORIES INC (CN)
International Classes:
C07D239/48; A61P29/00; A61P35/00
Domestic Patent References:
WO2016168619A1 | 2016-10-20 | |||
WO2008032036A1 | 2008-03-20 | |||
WO2007048064A2 | 2007-04-26 |
Foreign References:
CN105828823A | 2016-08-03 | |||
CN103483273A | 2014-01-01 | |||
CN1946701A | 2007-04-11 |
Other References:
YAO, D.H. ET AL.: "Design, Synthesis and Structure-activity Relationship Studies of a Focused Library of Pyrimidine Moiety with Anti-proliferative and Anti-metastasis Activities in Triple Negative Breast Cancer", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 140, 20 September 2017 (2017-09-20), pages 155 - 171, XP085227232, ISSN: 0223-5234
Attorney, Agent or Firm:
MSJ LAW OFFICE (CN)
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