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Patent Searching and Data


Title:
4-PYRIMIDINEDIAMINE SMALL MOLECULAR ORGANIC COMPOUNDS AND DERIVATIVES THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/219281
Kind Code:
A1
Abstract:
Disclosed is a class of 4-pyrimidinediamine small molecular organic compounds or related analogues or pharmaceutically acceptable salts thereof, with the structures thereof as shown in formulae (I)-(VI). Also disclosed are the use of the 4-pyrimidinediamine small molecular organic compounds or pharmaceutical compositions thereof in the preparation of drugs for preventing and/or treating various malignant tumours, autoimmune diseases, inflammation, etc., and the use of same as an inhibitor of B cell lymphokine 6 (BCL6) in the preparation of a drug for preventing and/or treating BCL6-mediated diseases.

Inventors:
CHEN YIHUA (CN)
LIU MINGYAO (CN)
GUO WEIKAI (CN)
XING YAJING (CN)
HUANG DONGXIA (CN)
YI ZHENGFANG (CN)
DU BING (CN)
ZHANG QIANSEN (CN)
Application Number:
PCT/CN2018/088932
Publication Date:
December 06, 2018
Filing Date:
May 30, 2018
Export Citation:
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Assignee:
UNIV EAST CHINA NORMAL (CN)
BIORAY LABORATORIES INC (CN)
International Classes:
C07D239/48; A61P29/00; A61P35/00
Domestic Patent References:
WO2016168619A12016-10-20
WO2008032036A12008-03-20
WO2007048064A22007-04-26
Foreign References:
CN105828823A2016-08-03
CN103483273A2014-01-01
CN1946701A2007-04-11
Other References:
YAO, D.H. ET AL.: "Design, Synthesis and Structure-activity Relationship Studies of a Focused Library of Pyrimidine Moiety with Anti-proliferative and Anti-metastasis Activities in Triple Negative Breast Cancer", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 140, 20 September 2017 (2017-09-20), pages 155 - 171, XP085227232, ISSN: 0223-5234
Attorney, Agent or Firm:
MSJ LAW OFFICE (CN)
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