Title:
4,4-DIPHENYL PIPERIDINE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PHARMACEUTICAL COMPOSITION USING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/130207
Kind Code:
A1
Abstract:
The present invention pertains to the field of pharmaceutical chemicals, and discloses a 4,4-diphenyl piperidine compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition using the same, and a use thereof. Specifically, the present invention discloses a compound represented by formula I or a pharmaceutically acceptable salt thereof, and further discloses a pharmaceutical composition comprising the compound or the pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof and the pharmaceutical composition using the same of the present invention have an obvious N-type calcium channel blocking activity, have desirable pharmacokinetic properties, and can effectively relieve pain, and have the potential of being used as a new drug for the prophylaxis or treatment of pain, stroke, cerebral ischemia, alcohol addiction, alcoholism, nephropathy, addictive disorders caused by analgesic drugs or tolerability disorders caused by analgesic drugs.
Inventors:
ZHANG CHENG (CN)
WANG HAOSHAN (CN)
DONG GUOXING (CN)
WU NING (CN)
ZHANG SHUZHUO (CN)
ZHUANG XIAOMEI (CN)
PANG CHONG (CN)
WANG JUAN (CN)
YANG RIFANG (CN)
ZHENG JIANQUAN (CN)
LI JIN (CN)
YUN LIUHONG (CN)
WANG HAOSHAN (CN)
DONG GUOXING (CN)
WU NING (CN)
ZHANG SHUZHUO (CN)
ZHUANG XIAOMEI (CN)
PANG CHONG (CN)
WANG JUAN (CN)
YANG RIFANG (CN)
ZHENG JIANQUAN (CN)
LI JIN (CN)
YUN LIUHONG (CN)
Application Number:
PCT/CN2018/072426
Publication Date:
July 19, 2018
Filing Date:
January 12, 2018
Export Citation:
Assignee:
ACAD OF MILITARY MEDICAL SCIENCES (CN)
International Classes:
C07D413/06; A61K31/451; A61K31/4535; A61K31/454; A61P9/10; A61P13/12; A61P25/04; A61P25/06; A61P29/00; C07D211/14; C07D409/06
Domestic Patent References:
| WO2001095856A2 | 2001-12-20 | |||
| WO2008031227A1 | 2008-03-20 | |||
| WO2008043183A1 | 2008-04-17 |
Foreign References:
| US4016280A | 1977-04-05 | |||
| CN102239146A | 2011-11-09 | |||
| CN1361775A | 2002-07-31 | |||
| US20040204404A1 | 2004-10-14 |
Other References:
DATABASE C AS 24 October 2004 (2004-10-24), retrieved from STN Database accession no. 768332-29-2
DATABASE CAS 13 June 2004 (2004-06-13), retrieved from STN Database accession no. 692717-79-6
DOULGAS A. KLUMPP: "Dicationic Intermediates Involving Protonated Amides: Dual Modes of Reactivity Including the Acylation of Arenes", ORGANIC LETTERS, vol. 6, no. 11, 29 April 2004 (2004-04-29), pages 1789 - 1792, XP055507909, ISSN: 1523-7060
DATABASE CAS 13 June 2004 (2004-06-13), retrieved from STN Database accession no. 692717-79-6
DOULGAS A. KLUMPP: "Dicationic Intermediates Involving Protonated Amides: Dual Modes of Reactivity Including the Acylation of Arenes", ORGANIC LETTERS, vol. 6, no. 11, 29 April 2004 (2004-04-29), pages 1789 - 1792, XP055507909, ISSN: 1523-7060
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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