4,5-DIHYDRONAPHTHO[1,2-b]THIOPHENE DERIVATIVE - TAISHO PHARMACEUTICAL CO LTD

Title:

4,5-DIHYDRONAPHTHO[1,2-b]THIOPHENE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2005/012284

Kind Code:

A1

Abstract:

A 4,5-dihydronaphtho[1,2-b]thiophene derivative represented by the formula (1) (wherein R¹ represents C_1-10 1-hydroxyalkyl or C_1-10 acyl, and R² and R³ are separately bonded in respective positions selected among the 6-, 7-, 8-, and 9-positions and each independently represents hydrogen, halogeno, C_1-10 alkyl, hydroxy, C_1-10 alkoxy, C_1-5 alkenyloxy, C_1-5 alkynyloxy, benzyloxy, etc., provided that when R¹ is acyl and R² is hydrogen, then R³ is neither hydrogen nor acetyl) or a pharmaceutically acceptable salt of the derivative. It is a novel compound effective in reducing triglyceride amount in the liver and reducing blood sugar level.

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Inventors:

TAGUCHI MINORU (JP)
SUZUKI RYO (JP)
MIKAMI AYAKO (JP)

Application Number:

PCT/JP2004/010944

Publication Date:

February 10, 2005

Filing Date:

July 30, 2004

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Assignee:

TAISHO PHARMACEUTICAL CO LTD (JP)
TAGUCHI MINORU (JP)
SUZUKI RYO (JP)
MIKAMI AYAKO (JP)

International Classes:

A61K31/381; A61P3/04; A61P3/06; A61P3/10; C07D319/18; C07D333/74; C07D495/04; (IPC1-7): C07D333/74; C07D495/04; A61K31/381; A61P3/04; A61P3/06; A61P3/10

Foreign References:

JPS61194081A

1986-08-28

Other References:

CLARKE K. TE AL.: "Naphtho[1,2-b]thiophene. Part 2. Subsitution reactions of derivatives with one or more substituents in the thiophene ring and of the 4,5-dihydro-derivative", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC NAD BIO-ORGANIC CHEMISTRY, no. 1, 1977, pages 63 - 68, XP002904188
See also references of EP 1650202A4

Attorney, Agent or Firm:

Satori, Soichi c/o TAISHO PHARMACEUTICAL CO. (LTD. INTELLECTUAL PROPERTY DIVISION 24-1 Takada 3-chom, Toshima-ku Tokyo 33, JP)

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