Title:
5-THIA-$g(v)-SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2000/003980
Kind Code:
A1
Abstract:
5-Thia-$g(v)-substituted phenyl-prostaglandin E derivatives represented by general formula (I) wherein each symbol is as defined in the specification. Because of being capable of bonding strongly to PEG¿2?receptors (in particular, the subtype EP¿4?), the compounds represented by general formula (I) are expected as useful in preventing and/or treating immunologic diseases, asthma, bone dysplasia, nerve cell death, lung failure, hepatopathy, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory syndrome, ambustion pain, sepsis, hemophagous syndrome, macrophage activation syndrome, Still disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock, etc. Moreover, these compounds participate in sleep disorders and platelet aggregation and, therefore, are expected as useful in preventing/treating these diseases.
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Inventors:
MARUYAMA TORU (JP)
OHUCHIDA SHUICHI (JP)
OHUCHIDA SHUICHI (JP)
Application Number:
PCT/JP1999/003798
Publication Date:
January 27, 2000
Filing Date:
July 14, 1999
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
MARUYAMA TORU (JP)
OHUCHIDA SHUICHI (JP)
MARUYAMA TORU (JP)
OHUCHIDA SHUICHI (JP)
International Classes:
A61K31/557; A61K47/40; C07C405/00; (IPC1-7): C07C405/00; A61K31/557; A61K47/40
Foreign References:
| JPH07233144A | 1995-09-05 | |||
| JPH03223244A | 1991-10-02 | |||
| JPS6379870A | 1988-04-09 |
Other References:
See also references of EP 1097922A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Nihonbashi-Ningyocho 2-chome Chuo-ku Tokyo, JP)
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