Title:
5-MEMBERED HETEROCYCLES, PREPARATION AND USE THEREOF AS MAO INHIBITORS AND LIPID PEROXIDATION INHIBITORS, PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO2002083656
Kind Code:
A3
Abstract:
The invention relates to thiazole, oxazole or imidazole derivatives having at least one of the following pharmacological activities: inhibition of monoamine oxidases (MAO); inhibition of lipid peroxidation; modulation of sodium channels. The inventive compounds comprise, for example, 2,6-ditert-butyl-4-{2-[2-(methylamino)ethyl]-1,3-thiazol-4-yl}phenol; et le 2-[4-(1,1'-biphenyl-4-yl)-1H-imidazol-2-yl]ethylcarbamate de 4-methylpenty l. By virtue of their pharmacological properties, said compounds can be used to treat one of the following disorders or diseases: Parkinson's disease, senile dementia, Alzheimer's disease, Huntington's chorea, amyotrophic lateral sclerosis, schizophrenia, depression, psychoses, migraine or pain, especially neuropathic pain.
Inventors:
HARNETT JEREMIAH (FR)
BIGG DENNIS (FR)
LIBERATORE ANNE-MARIE (FR)
ROLLAND ALAIN (FR)
BIGG DENNIS (FR)
LIBERATORE ANNE-MARIE (FR)
ROLLAND ALAIN (FR)
Application Number:
PCT/FR2002/001218
Publication Date:
January 03, 2003
Filing Date:
April 09, 2002
Export Citation:
Assignee:
SOD CONSEILS RECH APPLIC (FR)
HARNETT JEREMIAH (FR)
BIGG DENNIS (FR)
LIBERATORE ANNE-MARIE (FR)
ROLLAND ALAIN (FR)
HARNETT JEREMIAH (FR)
BIGG DENNIS (FR)
LIBERATORE ANNE-MARIE (FR)
ROLLAND ALAIN (FR)
International Classes:
A61K31/33; A61K31/416; A61K31/417; A61K31/421; A61K31/426; A61K31/454; A61K31/497; A61K31/5377; A61K31/538; A61K31/541; C07D233/64; A61K31/5415; A61K31/551; A61P25/00; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P43/00; C07D233/50; C07D233/54; C07D263/32; C07D277/20; C07D277/28; C07D277/30; C07D277/34; C07D401/06; C07D403/10; C07D417/04; C07D417/06; C07D417/14; (IPC1-7): C07D277/28; A61K31/33; A61P43/00; C07D277/34; C07D417/04; C07D417/06; C07D233/50; C07D401/06; C07D417/14; C07D233/54
Domestic Patent References:
| WO1997013768A1 | 1997-04-17 | |||
| WO1998058934A1 | 1998-12-30 | |||
| WO2001026656A2 | 2001-04-19 |
Foreign References:
| US5326770A | 1994-07-05 |
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