5-O-DESOSAMINYLERYTHRONOLIDE A DERIVATIVE - TAISHO PHARMACEUTICAL CO LTD

Title:

5-O-DESOSAMINYLERYTHRONOLIDE A DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1993/021200

Kind Code:

A1

Abstract:

Object: to provide a novel macrolide antibiotic having a potent antibacterial activity. Constitution: a tricyclic carbamate derivative of a 3-oxo-6-methoxy-substituted 5-O-desosaminylerythronolide A derivative represented by general formula (I), and a pharmaceutically acceptable acid addition salt thereof. In formula (I), -A$(1,3)$ represents -N(R3)- (wherein R3 represents hydrogen or C1-C3 alkyl) or -N=; and R1 and R2 represent each C1-C3 alkyl. An intermediate, represented by general formula (II), useful for producing the 3-oxo-substituted 5-O-desosaminylerythronolide A derivative, wherein R4 represents acetyl or propionyl.

More Like This:

JP2023538590	Immunomodulation of myeloid-derived suppressor cell function for the treatment of cancer
JPH11100382	SULFONAMIDE-SUBSTITUTED COMPOUND, ITS PREPARATION, USE AS MEDICINE AND DIAGNOSTIC, AND PREPARATION CONTAINING THE SAME
WO/2009/026701	SIRTUIN INHIBITORS

Inventors:

ASAKA TOSHIFUMI (JP)
KASHIMURA MASATO (JP)
MISAWA YOKO (JP)
MORIMOTO SHIGEO (JP)
HATAYAMA KATSUO (JP)

Application Number:

PCT/JP1993/000517

Publication Date:

October 28, 1993

Filing Date:

April 21, 1993

Export Citation:

Click for automatic bibliography generation Help

Assignee:

TAISHO PHARMACEUTICAL CO LTD (JP)
ASAKA TOSHIFUMI (JP)
KASHIMURA MASATO (JP)
MISAWA YOKO (JP)
MORIMOTO SHIGEO (JP)
HATAYAMA KATSUO (JP)

International Classes:

A61K31/395; C07D491/00; C07H17/00; C07H17/08; (IPC1-7): C07H17/00; C07H17/08

Domestic Patent References:

WO1992009614A1

1992-06-11

Foreign References:

EP0487411A1	1992-05-27
JPS62292795A	1987-12-19

Other References: