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Title:
5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES
Document Type and Number:
WIPO Patent Application WO2005021519
Kind Code:
A3
Abstract:
Compounds of Formula (I) in free or salt form, wherein R, R, R<2>, R<3>, R<4> and R<5> have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase such as inflammatory airway diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

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Inventors:
BLOOMFIELD GRAHAM CHARLES (GB)
BRUCE IAN (GB)
HAYLER JUDY FOX (GB)
LEBLANC CATHERINE (GB)
LE GRAND DARREN MARK (GB)
MCCARTHY CLIVE (CH)
Application Number:
PCT/EP2004/009586
Publication Date:
May 12, 2005
Filing Date:
August 27, 2004
Export Citation:
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Assignee:
NOVARTIS AG (CH)
NOVARTIS PHARMA GMBH (AT)
BLOOMFIELD GRAHAM CHARLES (GB)
BRUCE IAN (GB)
HAYLER JUDY FOX (GB)
LEBLANC CATHERINE (GB)
LE GRAND DARREN MARK (GB)
MCCARTHY CLIVE (CH)
International Classes:
C07D277/48; C07D417/12; C07D451/04; C07D471/04; (IPC1-7): A61K31/427; C07D277/48; C07D417/12; C07C275/26; A61P11/06
Domestic Patent References:
WO2002010162A12002-02-07
WO2001098270A22001-12-27
WO2003072557A12003-09-04
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