Title:
5' PHOSPHATE MIMICS
Document Type and Number:
WIPO Patent Application WO/2011/005860
Kind Code:
A3
Abstract:
The present invention provides nucleosides and oligonucleotides comprising a 5' phosphate mimics of formula (IVc) or (Vc). One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
Inventors:
MANOHARAN MUTHIAH (US)
RAJEEV KALLANTHOTTATHIL G (US)
PRHAVC MARIJA (US)
ZLATEV IVAN (US)
RAJEEV KALLANTHOTTATHIL G (US)
PRHAVC MARIJA (US)
ZLATEV IVAN (US)
Application Number:
PCT/US2010/041209
Publication Date:
May 10, 2013
Filing Date:
July 07, 2010
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS INC (US)
MANOHARAN MUTHIAH (US)
RAJEEV KALLANTHOTTATHIL G (US)
PRHAVC MARIJA (US)
ZLATEV IVAN (US)
MANOHARAN MUTHIAH (US)
RAJEEV KALLANTHOTTATHIL G (US)
PRHAVC MARIJA (US)
ZLATEV IVAN (US)
International Classes:
C07H19/213; C07H19/11
Domestic Patent References:
| WO1996040705A1 | 1996-12-19 |
Foreign References:
| US20050266422A1 | 2005-12-01 | |||
| US5874552A | 1999-02-23 |
Other References:
BRETT C. BOOKSER ET AL: "High-Throughput Synthesis of HepDirect Prodrugs of Nucleoside Monophosphates", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 10, no. 4, 1 July 2008 (2008-07-01), pages 567 - 572, XP055056898, ISSN: 1520-4766, DOI: 10.1021/cc8000212
Attorney, Agent or Firm:
TOWNES, Jeffrey, N. et al. (2318 Mill RoadSuite 110, Alexandria VA, US)
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