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Title:
5-PYRIMIDINE-6-OXY-PYRAZOLOPYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/244530
Kind Code:
A1
Abstract:
The present invention relates to a 5-pyrimidine-6-oxy-pyrazolopyridine derivative and pharmaceutically acceptable salts thereof, a preparation method therefor and an application thereof. The chemical structural formula (II) of the 5-pyrimidine-6-oxy-pyrazolopyridine derivative is shown in the figure. The derivative and pharmaceutically acceptable salts thereof block a TGF-β/ERK signaling pathway by activating a sGC-cGMP pathway, thereby exerting the anti-fibrosis effect thereof. Therefore, as a novel sGC agonist, the derivative can exert anti-fibrosis and anti-tissue remodeling effects by up-regulating cGMP levels, and thus becomes a new strategy for drug treatment of pulmonary fibrosis diseases.

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Inventors:
LI QIANBIN (CN)
HU GAOYUN (CN)
HU LIQING (CN)
CHEN ZHUO (CN)
Application Number:
PCT/CN2020/094057
Publication Date:
December 10, 2020
Filing Date:
June 03, 2020
Export Citation:
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Assignee:
UNIV CENTRAL SOUTH (CN)
International Classes:
C07D471/04; A61P11/00
Domestic Patent References:
WO2011095534A12011-08-11
WO2018167142A12018-09-20
WO2018089330A22018-05-17
Foreign References:
CN110305125A2019-10-08
CN108558876A2018-09-21
DE19744027A11999-04-08
Attorney, Agent or Firm:
CHANGSHA ZONEKEY PATENT LAW FIRM (CN)
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