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Title:
5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2006/011466
Kind Code:
A1
Abstract:
Disclosed are a compound and pharmaceutically acceptable salts thereof represented by the general formula (1) below. (In the formula (1), R1, R2, R3, R4 and X are the same as R1, R2, R3, R4 and X defined in the description.)

Inventors:
Isshiki, Yoshiaki c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Kohchi, Yasunori c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Mizuguchi, Eisaku c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Iikura, Hitoshi c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwar, Kamakura-shi Kanagawa 30, 24785, JP)
Matsubara, Yasuaki c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Tsujii, Shinji c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Shimma, Nobuo c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Miwa, Masanori c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Aida, Satoshi c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Kohchi, Masami c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Murata, Takeshi c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Aso, Kosuke c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Application Number:
PCT/JP2005/013620
Publication Date:
February 02, 2006
Filing Date:
July 26, 2005
Export Citation:
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Assignee:
CHUGAI SEIYAKU KABUSHIKI KAISHA (5-1 Ukima 5-chome, Kita-ku Tokyo, 43, 11585, JP)
Isshiki, Yoshiaki c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Kohchi, Yasunori c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Mizuguchi, Eisaku c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Iikura, Hitoshi c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwar, Kamakura-shi Kanagawa 30, 24785, JP)
Matsubara, Yasuaki c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Tsujii, Shinji c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Shimma, Nobuo c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Miwa, Masanori c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Aida, Satoshi c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Kohchi, Masami c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Murata, Takeshi c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
Aso, Kosuke c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (200 Kajiwara, Kamakura-sh, Kanagawa 30, 24785, JP)
International Classes:
C07C259/10; A61K31/166; A61K31/4015; A61K31/4164; A61K31/42; A61K31/421; A61K31/45; A61K31/505; A61K31/535; A61K31/5375; A61K31/539; A61P1/16; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P25/28; A61P29/00; A61P31/04; A61P31/18; A61P37/00; A61P37/06; A61P43/00; C07C11/24; C07C317/04; C07C323/12; C07D207/27; C07D211/76; C07D233/64; C07D239/10; C07D261/04; C07D263/24; C07D265/02; C07D265/32; C07D273/01; C07D295/08
Domestic Patent References:
WO2005028426A12005-03-31
Foreign References:
JP2003527379A2003-09-16
Other References:
See also references of EP 1780197A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (Kantetsu Tsukuba Bldg, 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi Ibaraki, 300-0847, JP)
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