Title:
5,11-DIHYDRODIBENZ[b,e][1,4]OXAZEPINE DERIVATIVES AND DRUG COMPOSITIONS CONTAING THE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1997/033885
Kind Code:
A1
Abstract:
5,11-Dihydrodibenz[b,e][1,4]oxazepine derivatives such as (R)-(+)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenz[b,e][1,4]oxazepine or (R)-(+)-5,11-dihydro-5-[1-(4-fluorophenethyl)-2-pyrrolidinylmethyl]dibenz[b,e][1,4]oxazepine; stereoisomers or them, pharmacologically acceptable salts of them and hydrates thereof; and drug compositions containing them. These compounds exhibit an excellent activity of improving the motor function of the digestive tract without any adverse effect.
Inventors:
TANAKA YUJI (JP)
MISUMI KEIJI (JP)
KAWAKAMI YOSHINARI (JP)
MORIGUCHI MASAHIKO (JP)
TAKAHASHI KAZUYOSHI (JP)
OKAMOTO HIROKI (JP)
KAMISAKI TOSHIAKI (JP)
INOUE KIMIHIRO (JP)
SATO MAKOTO (JP)
MISUMI KEIJI (JP)
KAWAKAMI YOSHINARI (JP)
MORIGUCHI MASAHIKO (JP)
TAKAHASHI KAZUYOSHI (JP)
OKAMOTO HIROKI (JP)
KAMISAKI TOSHIAKI (JP)
INOUE KIMIHIRO (JP)
SATO MAKOTO (JP)
Application Number:
PCT/JP1997/000754
Publication Date:
September 18, 1997
Filing Date:
March 11, 1997
Export Citation:
Assignee:
AJINOMOTO KK (JP)
TANAKA YUJI (JP)
MISUMI KEIJI (JP)
KAWAKAMI YOSHINARI (JP)
MORIGUCHI MASAHIKO (JP)
TAKAHASHI KAZUYOSHI (JP)
OKAMOTO HIROKI (JP)
KAMISAKI TOSHIAKI (JP)
INOUE KIMIHIRO (JP)
SATO MAKOTO (JP)
TANAKA YUJI (JP)
MISUMI KEIJI (JP)
KAWAKAMI YOSHINARI (JP)
MORIGUCHI MASAHIKO (JP)
TAKAHASHI KAZUYOSHI (JP)
OKAMOTO HIROKI (JP)
KAMISAKI TOSHIAKI (JP)
INOUE KIMIHIRO (JP)
SATO MAKOTO (JP)
International Classes:
A61P1/00; C07D413/06; C07D413/14; (IPC1-7): C07D413/06; C07D413/14; A61K31/395
Domestic Patent References:
| WO1993009104A1 | 1993-05-13 |
Foreign References:
| EP0404359A1 | 1990-12-27 |
Other References:
See also references of EP 0889043A4
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