Title:
5,5'-LINKED 1,1'-BIPHENYL AXIAL CHIRAL LIGANDS AND PREPARATION METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/073699
Kind Code:
A1
Abstract:
5,5'-linked 1,1'-biphenyl axial chiral ligands in the field of chemical engineering
technique are disclosed. The present ligands have both central chirality of
oxazoline and axial chirality of biphenyl. The present ligands are expected
to be highly effective and highly stereoselective as chiral ligands for various
types of metal-catalyzed asymmetric reactions and display wide utility. The
general structure of the present ligands is: in which n=5,6,7,8,9,10,11 or 12;R1=hydrogen,
alkyl, substituted aryl, substituted benzyl; R2=hydrogen, alkyl,
substituted aryl,substituted benzyl; R3=hydrogen, alkyl, substituted
aryl, substituted benzyl;R4= hydrogen, alkyl, substituted aryl,
substituted benzyl.
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Inventors:
ZHANG WANBIN (CN)
ZHANG YONGJIAN (CN)
WANG FEIJUN (CN)
ZHANG YONGJIAN (CN)
WANG FEIJUN (CN)
Application Number:
PCT/CN2006/003696
Publication Date:
July 05, 2007
Filing Date:
December 29, 2006
Export Citation:
Assignee:
UNIV SHANGHAI JIAOTONG (CN)
ZHANG WANBIN (CN)
ZHANG YONGJIAN (CN)
WANG FEIJUN (CN)
ZHANG WANBIN (CN)
ZHANG YONGJIAN (CN)
WANG FEIJUN (CN)
International Classes:
C07D263/12
Other References:
GANT T.G. ET AL.: "The first enantioselective synthesisof the chemotactic factor by an intramolecular [2+1] cyclization using a new chiral catalyst", TETRAHEDRON LETT., vol. 36, no. 48, 1995, pages 8745 - 8748, XP004026821
IMAI Y. ET AL.: "Novel Chiral Bisoxazoline Ligands with a Biphenyl Blackbone:Preparation, Complexation, and Application in Asymmetric Catalytic Reactions", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 11, 2000, pages 3326 - 3333, XP003015209
IMAI Y. ET AL.: "Novel axial chiral catalyst derived from biphenyl ligand bearing only two ortho-substituents", TETRAHEDRON LETTERS, vol. 38, no. 15, 1997, pages 2681 - 2684, XP004058303
QIAO ZHEN ET AL.: "Progress of chiral bis(oxazoline)-metal complexes utilized in asymmetric cyclopropanation", YOUJI HUAXUE, vol. 24, no. 1, 2004, pages 15 - 22, XP008082989
QIAO ZHEN ET AL.: "Progress in synthesis of chirak bis(oxazoline) ligands", YOUJI HUAXUE, vol. 24, no. 12, 2004, pages 1542 - 1552, XP008082988
IMAI Y. ET AL.: "Novel Chiral Bisoxazoline Ligands with a Biphenyl Blackbone:Preparation, Complexation, and Application in Asymmetric Catalytic Reactions", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 11, 2000, pages 3326 - 3333, XP003015209
IMAI Y. ET AL.: "Novel axial chiral catalyst derived from biphenyl ligand bearing only two ortho-substituents", TETRAHEDRON LETTERS, vol. 38, no. 15, 1997, pages 2681 - 2684, XP004058303
QIAO ZHEN ET AL.: "Progress of chiral bis(oxazoline)-metal complexes utilized in asymmetric cyclopropanation", YOUJI HUAXUE, vol. 24, no. 1, 2004, pages 15 - 22, XP008082989
QIAO ZHEN ET AL.: "Progress in synthesis of chirak bis(oxazoline) ligands", YOUJI HUAXUE, vol. 24, no. 12, 2004, pages 1542 - 1552, XP008082988
Attorney, Agent or Firm:
JEEKAI & PARTNERS (Jinyu Tower A129 West Xuan Wu Men Street, Beijing 1, CN)
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