Title:
5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS
Document Type and Number:
WIPO Patent Application WO1995014011
Kind Code:
A3
Abstract:
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.
Inventors:
ELLSWORTH EDMUND LEE (US)
LUNNEY ELIZABETH (US)
TAIT BRADLEY DEAN (US)
LUNNEY ELIZABETH (US)
TAIT BRADLEY DEAN (US)
Application Number:
PCT/US1994/012234
Publication Date:
June 29, 1995
Filing Date:
October 26, 1994
Export Citation:
Assignee:
PARKE DAVIS & CO (US)
International Classes:
A61K31/35; A61K31/351; A61K31/352; A61K31/365; A61K31/366; A61K31/38; A61K31/382; C07D335/02; A61K31/44; A61K31/443; A61P31/04; A61P31/12; A61P31/18; C07C321/26; C07C323/20; C07C323/22; C07C381/04; C07D211/84; C07D211/86; C07D309/32; C07D309/38; C07D311/96; C07D405/04; C07D405/06; C07D405/12; C07D407/06; C07D407/12; (IPC1-7): C07D309/32; C07D211/86; C07C323/22; C07D335/02; C07D405/12; C07D405/06; A61K31/365
Domestic Patent References:
| WO1994011361A1 | 1994-05-26 |
Foreign References:
| US3818046A | 1974-06-18 |
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