Title:
5,8-DIHYDROPTERIDINE-6,7-DIKETONE DERIVATIVE AS EGFR INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/101862
Kind Code:
A1
Abstract:
The present invention relates to a pyrimidopyrimidine dione derivative as an EGFR inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, the pharmaceutical composition containing the compound of formula I and the use of the compound in preparing drugs for treating EGFR-related diseases or inhibiting EGFR.
Inventors:
LI HONGLIN (CN)
XU YUFANG (CN)
DING JIAN (CN)
HAO YONGJIA (CN)
SUN DEHENG (CN)
WANG XIA (CN)
TONG YI (CN)
ZHANG CHEN (CN)
XIE HUA (CN)
XU YUFANG (CN)
DING JIAN (CN)
HAO YONGJIA (CN)
SUN DEHENG (CN)
WANG XIA (CN)
TONG YI (CN)
ZHANG CHEN (CN)
XIE HUA (CN)
Application Number:
PCT/CN2016/110437
Publication Date:
June 22, 2017
Filing Date:
December 16, 2016
Export Citation:
Assignee:
UNIV EAST CHINA SCIENCE & TECH (CN)
International Classes:
C07D475/00; A61K31/519; A61P35/00; A61P35/02
Domestic Patent References:
| WO2013071217A1 | 2013-05-16 |
Foreign References:
| CN1373763A | 2002-10-09 | |||
| US20060047118A1 | 2006-03-02 |
Other References:
HAO, YONGJIA ET AL.: "Discovery and Structural Optimization of N5-Substituted 6, 7-Dioxo-6, 7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, 11 November 2016 (2016-11-11), pages 7111 - 7124, XP055392174
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF:
Previous Patent: ATHLETIC SHOE
Next Patent: BISPECIFIC CONJUGATED ANTIBODY, PREPARATION METHOD THEREFOR AND USE THEREOF
Next Patent: BISPECIFIC CONJUGATED ANTIBODY, PREPARATION METHOD THEREFOR AND USE THEREOF