6, 5-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

WIPO Patent Application WO/2018/112840

A1

6, 5-fused heteroarylpiperidine ether compounds and pharmaceutical compositions thereof are disclosed. The 6, 5-fused heteroarylpiperidine ether compounds are allosteric modulators of the M4 muscarinic acetylcholine receptor and can be used in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved.

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GAO XIAOLEI (US)
KNOWLES SANDRA L (US)
LI CHUNSING (CN)
LO MICHAEL MAN-CHU (US)
MAZZOLA ROBERT D JR (US)
ONDEYKA DEBRA L (US)

PCT/CN2016/111527

June 28, 2018

December 22, 2016

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MERCK SHARP & DOHME (US)
GAO XIAOLEI (US)
KNOWLES SANDRA L (US)
LI CHUNSING (CN)
LO MICHAEL MAN CHU (US)
MAZZOLA ROBERT D JR (US)
ONDEYKA DEBRA L (US)

A61K31/437; C07D487/04; A61K31/52; A61P25/28; C07D471/04

WO2006125180A1	2006-11-23
WO2011034741A1	2011-03-24
WO2015193281A1	2015-12-23

DATABASE Registry 18 May 2016 (2016-05-18), retrieved from STN Database accession no. RN 1912672-09-3
DATABASE Registry 7 June 2015 (2015-06-07), retrieved from STN Database accession no. RN 1774819-47-4
DATABASE Registry 9 March 2014 (2014-03-09), retrieved from STN Database accession no. RN 1564913-75-2

WU, FENG & ZHANG CO. (CN)

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