Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2016/191935
Kind Code:
A1
Abstract:
The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Inventors:
SHEN DONG-MING (US)
DWYER MICHAEL (US)
SINZ CHRISTOPHER J (US)
WANG DEPING (US)
STACHEL SHAWN (US)
PAONE DANIEL (US)
NOMLAND ASHLEY (US)
BERGER RICHARD (US)
SHIPE WILLIAM D (US)
CHEN YILI (US)
QIAN YIMIN (CN)
XU SHIMIN (CN)
HU CHUNMEI (CN)
FU JIANMIN (CN)
GUO ZHIGANG (CN)
LI HAITANG (CN)
BO YINGJIAN (CN)
Application Number:
PCT/CN2015/080267
Publication Date:
December 08, 2016
Filing Date:
May 29, 2015
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
MERCK SHARP & DOHME (US)
MSD R & D (CHINA) CO LTD (CN)
SHEN DONG-MING (US)
DWYER MICHAEL (US)
SINZ CHRISTOPHER J (US)
WANG DEPING (US)
STACHEL SHAWN (US)
PAONE DANIEL (US)
NOMLAND ASHLEY (US)
BERGER RICHARD (US)
SHIPE WILLIAM D (US)
CHEN YILI (US)
QIAN YIMIN (CN)
XU SHIMIN (CN)
HU CHUNMEI (CN)
FU JIANMIN (CN)
GUO ZHIGANG (CN)
LI HAITANG (CN)
BO YINGJIAN (CN)
International Classes:
C07D487/04; A61K31/519; A61P25/00; A61P25/16; A61P25/22
Domestic Patent References:
WO2010090737A12010-08-12
Foreign References:
CA2524898A12004-11-18
Attorney, Agent or Firm:
WU, FENG & ZHANG CO. (CN)
Download PDF: