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Title:
6-DEOXIDIZED SULFONE CYCLODEXTRIN DERIVATIVES AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/127600
Kind Code:
A1
Abstract:
6-deoxidized sulfone cyclodextrin derivatives with structure of formula (I) are provided by the present invention, which are prepared by the steps of oxidation 1 by using 6-deoxidized thioether amino acid cyclodextrin derivative or 6-deoxidized thioether cyclodextrin derivative as raw material to obtain 6-deoxidized sulfoxide cyclodextrin derivative, further oxidizing the resultant to obtain 6-deoxidized sulfonyl cyclodextrin derivative. In which, the 6-deoxidized thioether amino acid cyclodextrin derivative is prepared by following procedure: using acetic acid containing R3 substituent group to obtain dihalide through halogenation, condensing with amino acid to obtain amide, adding sulfur reagent to obtain sulfur-containing compound, removing the protecting group to obtain sulfhydryl compound, and then condensing with halogenated cyclodextrin to obtain the product. The compound provided by the present invention can be used to antagonize muscle relaxation effect induced by muscle relaxant drugs in patients or animals, has reversal and antagonistic effect to muscle relaxation induced by muscle relaxant drugs, and can be used to prepare drugs which have antagonistic effect to muscle relaxation.

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Inventors:
QI YOUMAO (CN)
JIE QING (CN)
ZHANG FENGMIN (CN)
YU BAOCHUN (CN)
Application Number:
PCT/CN2010/072334
Publication Date:
November 11, 2010
Filing Date:
April 29, 2010
Export Citation:
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Assignee:
HANGZHOU ADAMERCK PHARMLABS IN (CN)
QI YOUMAO (CN)
JIE QING (CN)
ZHANG FENGMIN (CN)
YU BAOCHUN (CN)
International Classes:
C08B37/16; A61K31/724; A61P43/00
Domestic Patent References:
WO2006001844A22006-01-05
Foreign References:
CN101591402A2009-12-02
CN1402737A2003-03-12
US20050153932A12005-07-14
JP2000344803A2000-12-12
Attorney, Agent or Firm:
HANGZHOU TIAN XIN PATENT AGENT, INC. (No. 281 Zhong He Zhong Road, Shangchen, Hangzhou Zhejiang 3, CN)
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