Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
6-DISULFIDE-SUBSTITUTED-2'-DEOXYGUANOSINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/042729
Kind Code:
A1
Abstract:
Disclosed are a 6-disulfide-substituted-2'-deoxyguanosine compound and a preparation method therefor and a use thereof in an anti-tumor drug. Using 2'-deoxyguanosine as a structure mother nucleus, the present invention designs and synthesizes a series of brand-new thioredoxin-1(Trx-1) inhibitors. The compound of the present invention is in a structure of formula I, and Trx-1 activity inhibition testing is performed on such compounds, showing clear inhibitory activity. It is indicated from in vivo and in vitro study that these compounds show significant tumor inhibitory effects toward multiple types of tumors, can be applied to drugs of tumors related to human body cell proliferation, and provide a new way for the study of anti-cancer drugs.

More Like This:
JP2003518929INDUSTRIAL APPLICABILITY The basal side selection signal and its inhibitor.
JP2002504340INDUSTRIAL APPLICABILITY The composition and method for sensitizing human tumor cells and inhibiting the growth of human tumor cells.
JP2004231557EPINEPHRINE-CONTAINING ANTITUMOR AGENT
Inventors:
YU LUSHAN (CN)
ZENG SU (CN)
ZHANG YANG (CN)
Application Number:
PCT/CN2019/092094
Publication Date:
March 05, 2020
Filing Date:
June 20, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61P35/00; C07H19/173; A61P35/02; C07H1/00
Domestic Patent References:
WO2004094447A12004-11-04
WO2002033128A22002-04-25
Foreign References:
CN109053841A2018-12-21
Other References:
SANEYOSHI, MINEO ET AL.: "Synthetic Nucleosides and Nucleotides. X. Synthesis and Biological Activities of Several Purin-6-yl Benzyl Disulfides and Their Ribonucleosides", JOURNAL OF PHARMACOBIO-DYNAMICS, vol. 1, no. 3, 31 December 1978 (1978-12-31), XP002480550, ISSN: 0386-846X, DOI: 20190917140257X
SANEYOSHI, MINEO ET AL.: "Synthetic Nucleosides and Nucleotides. X. Synthesis and Biological Activities of Several Purin-6-yl Benzyl Disulfides and Their Ribonucleosides", JOURNAL OF PHARMACOBIO-DYNAMICS, vol. 1, no. 3, 31 December 1978 (1978-12-31), XP002480550, ISSN: 0386-846X, DOI: 20190917140308A
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: DISPLAY METHOD FOR DISPLAY SCREEN, ELECTRONIC DEVICE, AND STORAGE MEDIUM

Next Patent: BIPHENYL COMPOUND-CONTAINING LIQUID PREPARATION AND APPLICATION THEREOF