Title:
6- (PYRIDINYL) -4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS
Document Type and Number:
WIPO Patent Application WO2006036015
Kind Code:
A3
Abstract:
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof:wherein R1 represents a C1-C12 alkyl; R2 represents a hydrogen atom or the like; R3 represents a halogen or the like; q represents an integer of 1 to 7; R4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R5 represents a C6-C10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).
Inventors:
WATANABE KAZUTOSHI (JP)
FUKUNAGA KENJI (JP)
KOHARA TOSHIYUKI (JP)
UEHARA FUMIAKI (JP)
HIKI SHINSUKE (JP)
YOKOSHIMA SATOSHI (JP)
FUKUNAGA KENJI (JP)
KOHARA TOSHIYUKI (JP)
UEHARA FUMIAKI (JP)
HIKI SHINSUKE (JP)
YOKOSHIMA SATOSHI (JP)
Application Number:
PCT/JP2005/018497
Publication Date:
June 01, 2006
Filing Date:
September 29, 2005
Export Citation:
Assignee:
MITSUBISHI PHARMA CORP (JP)
SANOFI AVENTIS (FR)
WATANABE KAZUTOSHI (JP)
FUKUNAGA KENJI (JP)
KOHARA TOSHIYUKI (JP)
UEHARA FUMIAKI (JP)
HIKI SHINSUKE (JP)
YOKOSHIMA SATOSHI (JP)
SANOFI AVENTIS (FR)
WATANABE KAZUTOSHI (JP)
FUKUNAGA KENJI (JP)
KOHARA TOSHIYUKI (JP)
UEHARA FUMIAKI (JP)
HIKI SHINSUKE (JP)
YOKOSHIMA SATOSHI (JP)
International Classes:
C07D401/04; A61K31/505; A61K31/506; A61P25/28; C07D401/14; C07D409/14; C07D413/14
Domestic Patent References:
| WO2001070729A1 | 2001-09-27 | |||
| WO2003037888A1 | 2003-05-08 | |||
| WO2000018758A1 | 2000-04-06 | |||
| WO2004085408A1 | 2004-10-07 |
Foreign References:
| EP1136483A1 | 2001-09-26 | |||
| EP1454908A1 | 2004-09-08 |
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