Title:
6H-THIENO[2,3-E][1,2,4]TRIAZOLO[3,4-C][1,2,4]TRIAZEPINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/221679
Kind Code:
A1
Abstract:
This 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative or a salt thereof has BRD4 inhibitory activity and is therefore useful as a drug, especially as an agent to prevent and/or treat diseases involving BRD4.
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Inventors:
AONO HIROYUKI (JP)
SEKI IWAO (JP)
IMAMURA MIWA (JP)
TANAKA TOMOMI (JP)
SHIRAE SATOSHI (JP)
KAWASHIMA KENJI (JP)
YAMAZAKI YUSUKE (JP)
YAMAMOTO MINORU (JP)
SEKI IWAO (JP)
IMAMURA MIWA (JP)
TANAKA TOMOMI (JP)
SHIRAE SATOSHI (JP)
KAWASHIMA KENJI (JP)
YAMAZAKI YUSUKE (JP)
YAMAMOTO MINORU (JP)
Application Number:
PCT/JP2018/021040
Publication Date:
December 06, 2018
Filing Date:
May 31, 2018
Export Citation:
Assignee:
AYUMI PHARMACEUTICAL CORP (JP)
International Classes:
C07D495/14; A61K31/55; A61P1/04; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/08; A61P15/16; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| WO1997047622A1 | 1997-12-18 | |||
| WO1996016062A1 | 1996-05-30 | |||
| WO2016207204A1 | 2016-12-29 | |||
| WO2015078928A1 | 2015-06-04 |
Foreign References:
| JPH11228576A | 1999-08-24 | |||
| JP2013544847A | 2013-12-19 | |||
| JPS58118513A | 1983-07-14 | |||
| JP2016538307A | 2016-12-08 |
Other References:
DEEPAK, V. ET AL.: "In silico design and bioevaluation of selective benzotriazepine BRD4 inhibitors with potent antiosteoclastogenic activity", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 90, no. 1, 29 December 2016 (2016-12-29), pages 97 - 111, XP055610415, ISSN: 1747-0277, DOI: 10.1111/cbdd.12930
FILIPPAKOPOULOS, P.: "Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 6, 15 March 2012 (2012-03-15), pages 1878 - 1886, XP055070757, DOI: 10.1016/j.bmc.2011.10.080
ANN RHEUM DIS., vol. 75, no. 2, February 2016 (2016-02-01), pages 422 - 9
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J MOL CELL CARDIOL., vol. 63, October 2013 (2013-10-01), pages 175 - 9
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CELL, vol. 150, no. 4, 17 August 2012 (2012-08-17), pages 673 - 684
CURR ALZHEIMER RES., vol. 13, no. 9, 2016, pages 985 - 95
HUM MOL GENET., vol. 24, no. 14, 15 July 2015 (2015-07-15), pages 3982 - 3993
ATHEROSCLEROSIS, vol. 236, no. 1, September 2014 (2014-09-01)
METABOLISM., vol. 65, no. 6, June 2016 (2016-06-01), pages 904 - 14
PROGRESS IN MEDICINE, vol. 5, 1995, pages 2157 - 2161
"Molecular Design", vol. 7, 1990, HIROKAWA-SHOTEN LTD., article "Development of pharmaceuticals", pages: 163 - 198
FILIPPAKOPOULOS, P.: "Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 6, 15 March 2012 (2012-03-15), pages 1878 - 1886, XP055070757, DOI: 10.1016/j.bmc.2011.10.080
ANN RHEUM DIS., vol. 75, no. 2, February 2016 (2016-02-01), pages 422 - 9
INT IMMUNOPHARMACOL., vol. 29, no. 2, December 2015 (2015-12-01), pages 314 - 9
PHARMACOL RES., vol. 99, September 2015 (2015-09-01), pages 248 - 57
NATURE, vol. 468, pages 7327
PROC NATL ACAD SCI USA., vol. 112, no. 51, 22 December 2015 (2015-12-22), pages 15713 - 8
J MOL CELL CARDIOL., vol. 63, October 2013 (2013-10-01), pages 175 - 9
NUCLEIC ACIDS RES., vol. 41, no. 1, 7 January 2013 (2013-01-07), pages 277 - 87
CELL, vol. 150, no. 4, 17 August 2012 (2012-08-17), pages 673 - 684
CURR ALZHEIMER RES., vol. 13, no. 9, 2016, pages 985 - 95
HUM MOL GENET., vol. 24, no. 14, 15 July 2015 (2015-07-15), pages 3982 - 3993
ATHEROSCLEROSIS, vol. 236, no. 1, September 2014 (2014-09-01)
METABOLISM., vol. 65, no. 6, June 2016 (2016-06-01), pages 904 - 14
PROGRESS IN MEDICINE, vol. 5, 1995, pages 2157 - 2161
"Molecular Design", vol. 7, 1990, HIROKAWA-SHOTEN LTD., article "Development of pharmaceuticals", pages: 163 - 198
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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