Title:
7-CHROMANYL ESTERS OF PHENOLS AND BENZOIC ACIDS HAVING RETINOID-LIKE ACTIVITY
Document Type and Number:
WIPO Patent Application WO1992017426
Kind Code:
A3
Abstract:
Retinoid like activity is exhibited by compounds of the formula wherein the R1-R6 groups are independently H or straight chain or branched chain lower alkyl or cycloalkyl of 1 to 6 carbons; X symbolizes an ester or thioester linkage, Y is lower branched chain alkyl having 2 to 6 carbons, cycloalkyl having 3 to 6 carbons or is (CH2)n where n is an integer between 0 to 6 or is an alkenyl group of 2 to 6 carbons, and having 1 or 2 double bonds, or an alkynyl group of 2 to 6 carbons; and Z is H, OH, OR', OCOR', -COOH or a pharmaceutically acceptable salt COOR8, COONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12), CHOR13O, -COR', CR'(OR12)2, or CR'OR13O; where R' is an alky, cycloalkyl or alkenyl group containing 1-5 carbons, R8 is an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons,, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently or hydrogen, an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons or phenyl or lower alkyl phenyl, R11 is lower alkyl, and R13 is a divalent alkyl radical of 2-5 carbons.
Inventors:
CHANDRARATNA ROSHANTHA A S (US)
Application Number:
PCT/US1992/002346
Publication Date:
November 12, 1992
Filing Date:
March 25, 1992
Export Citation:
Assignee:
ALLERGAN INC (US)
International Classes:
A61K31/352; A61K31/415; A61P17/00; A61P17/06; A61P17/10; A61P17/16; A61P19/02; A61P27/02; A61P37/08; C07D311/58; (IPC1-7): C07C/
Foreign References:
| EP0337689A1 | 1989-10-18 | |||
| LU86259A1 | 1987-09-03 | |||
| US5006550A | 1991-04-09 |
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