Title:
7-METHYLTHIAZOLO[5,4-D]PYRIMIDINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/109158
Kind Code:
A1
Abstract:
Disclosed in the present invention is a 7-methylthiazolo[5,4-d]pyrimidine compound, and a preparation method therefor and the use thereof. The compound comprises a compound represented by formula (I) or a physiologically acceptable salt thereof, wherein R1 is hydrogen, substituted or unsubstituted alkyl, cycloalkyl, substituted or unsubstituted alkyl carbonyl, substituted or unsubstituted cycloalkyl carbonyl; and R2 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted aromatic heterocyclyl.
Inventors:
XIE JUN (CN)
JIANG CHUNYANG (CN)
LI HUI (CN)
LI HONGCHANG (CN)
ZHOU XIAOQUN (CN)
JIANG CHUNYANG (CN)
LI HUI (CN)
LI HONGCHANG (CN)
ZHOU XIAOQUN (CN)
Application Number:
PCT/CN2022/113008
Publication Date:
June 22, 2023
Filing Date:
August 17, 2022
Export Citation:
Assignee:
SHANGHAI SCIENPHARM CO LTD (CN)
International Classes:
C07D513/04; A61P35/00
Domestic Patent References:
| WO2017028810A1 | 2017-02-23 | |||
| WO2003045930A1 | 2003-06-05 |
Foreign References:
| CN101624371A | 2010-01-13 | |||
| CN112805280A | 2021-05-14 | |||
| CN103748099A | 2014-04-23 | |||
| CN101675053A | 2010-03-17 |
Other References:
LIN, SONGWEN ET AL.: "Discovery of New Thienopyrimidine Derivatives as Potent and Orally Efficacious Phosphoinositide 3-Kinase Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, no. 3, 23 December 2017 (2017-12-23), XP055877875, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.12.025
ZHANG, HONGWANG ET AL.: "Novel Influenza Polymerase PB2 Inhibitors for the Treatment of Influenza A Infection", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 29, no. 20, 24 August 2019 (2019-08-24), XP085831658, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2019.126639
MORADI HASSANALI, ESHGHI HOSSEIN, BAKAVOLI MEHDI: "Synthesis of Thiazolo[5,4-d][1,2,4]Triazolo[4,3-a]Pyrimidines as a New Class of Heterocyclic Compounds", JOURNAL OF CHEMICAL RESEARCH, SCIENCE REVIEWS LTD., GB, vol. 40, no. 5, 1 May 2016 (2016-05-01), GB , pages 276 - 279, XP093071469, ISSN: 1747-5198, DOI: 10.3184/174751916X14598638014154
HAN, FANGBIN ET AL.: "Discovery of a Novel Series of Thienopyrimidine as Highly Potent and Selective PI3K Inhibitors", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 4, 11 March 2015 (2015-03-11), pages 434 - 438, XP055365085, ISSN: 1948-5875, DOI: 10.1021/ml5005014
ZHANG, HONGWANG ET AL.: "Novel Influenza Polymerase PB2 Inhibitors for the Treatment of Influenza A Infection", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 29, no. 20, 24 August 2019 (2019-08-24), XP085831658, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2019.126639
MORADI HASSANALI, ESHGHI HOSSEIN, BAKAVOLI MEHDI: "Synthesis of Thiazolo[5,4-d][1,2,4]Triazolo[4,3-a]Pyrimidines as a New Class of Heterocyclic Compounds", JOURNAL OF CHEMICAL RESEARCH, SCIENCE REVIEWS LTD., GB, vol. 40, no. 5, 1 May 2016 (2016-05-01), GB , pages 276 - 279, XP093071469, ISSN: 1747-5198, DOI: 10.3184/174751916X14598638014154
HAN, FANGBIN ET AL.: "Discovery of a Novel Series of Thienopyrimidine as Highly Potent and Selective PI3K Inhibitors", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 4, 11 March 2015 (2015-03-11), pages 434 - 438, XP055365085, ISSN: 1948-5875, DOI: 10.1021/ml5005014
Attorney, Agent or Firm:
DUAN&DUAN LAW FIRM (CN)
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