Title:
7-NITRO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/253152
Kind Code:
A1
Abstract:
A 7-nitro-8-hydroxyquinoline derivative, a preparation method therefor and the medical use thereof. Specifically, disclosed are a compound as shown in general formula (I), a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the treatment of infectious diseases or cancers. The compound has excellent antibacterial and antitumor activities and can be developed into a drug for treating infectious diseases or tumors.
Inventors:
DENG YIJUN (CN)
WU LIANG (CN)
XIAO LU (CN)
WU LIANG (CN)
XIAO LU (CN)
Application Number:
PCT/CN2022/095835
Publication Date:
December 08, 2022
Filing Date:
May 30, 2022
Export Citation:
Assignee:
JIANGSU YAHONG MEDITECH CO LTD (CN)
ASIERIS PHARMACEUTICALS SHANGHAI CO LTD (CN)
ASIERIS PHARMACEUTICALS SHANGHAI CO LTD (CN)
International Classes:
C07D215/28; A61K31/47; A61K31/4709; A61K31/496; A61K31/5377; A61K31/55; A61P13/00; A61P31/00; A61P35/00; C07D401/04
Foreign References:
| US2394650A | 1946-02-12 | |||
| CN111960998A | 2020-11-20 |
Other References:
LI PENG,WANG FAN,LIN ZI-YUN,MA CHEN,HUANG HAI: "Synthesis of 7-Nitro-8-quinolinol", CHINESE JOURNAL OF SYNTHETIC CHEMISTRY, vol. 19, no. 5, 20 October 2011 (2011-10-20), pages 656 - 658, XP093011798, ISSN: 1005-4511, DOI: 10.15952/j.cnki.cjsc.2011.05.028
FLEMMING WAYNE C, PETTIT GEORGE K: "Synthesis of 2-Dialkylamino-6-and -7-hydroxy-5,8-dioxoquinolinesla", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 36, no. 23, 1 November 1971 (1971-11-01), pages 3490 - 3493, XP055558839
LIU CHANG, LE BLANC J. C. YVES, SCHNEIDER BRADLEY B., SHIELDS JEFRY, FEDERICO JAMES J., ZHANG HUI, STROH JUSTIN G., KAUFFMAN GREGO: "Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry", ACS CENTRAL SCIENCE, vol. 3, no. 2, 22 February 2017 (2017-02-22), pages 101 - 109, XP093011803, ISSN: 2374-7943, DOI: 10.1021/acscentsci.6b00297
DATABASE Registry 19 April 2017 (2017-04-19), ANONYMOUS : "2-Quinolinecarbonitrile, 8-hydroxy-7-nitro- (CA INDEX NAME)", XP093011812, retrieved from STN Database accession no. 2092238-20-3
MCNEIL GERSHON, GERSHON HERMAN, MCNEIL MAYNARD W: "8-Quinolinolsulfonic Acids1", J. ORG. CHEM, vol. 36, no. 23, 1 November 1971 (1971-11-01), pages 3494 - 3496, XP093011804, DOI: 10.1021/jo00822a005
FRESCO JAMES, FREISER HENRY: "Stabilities of Chelates of Certain Substituted 8-Quinolinols", INORGANIC CHEMISTRY, vol. 2, no. 1, 28 February 1963 (1963-02-28), London UK, pages 82 - 85, XP093011806
FREIREICH ET AL., CANCER CHEMOTHER REP, vol. 50, 1966, pages 219
T. W. GREENEG. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY
WANGHUA MALLBEIJING OUHE: "Energy Chemical", article "Technology, Sigma, J&K Scientific, Yishiming, Shanghai Shuya Chemical"
FLEMMING WAYNE C, PETTIT GEORGE K: "Synthesis of 2-Dialkylamino-6-and -7-hydroxy-5,8-dioxoquinolinesla", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 36, no. 23, 1 November 1971 (1971-11-01), pages 3490 - 3493, XP055558839
LIU CHANG, LE BLANC J. C. YVES, SCHNEIDER BRADLEY B., SHIELDS JEFRY, FEDERICO JAMES J., ZHANG HUI, STROH JUSTIN G., KAUFFMAN GREGO: "Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry", ACS CENTRAL SCIENCE, vol. 3, no. 2, 22 February 2017 (2017-02-22), pages 101 - 109, XP093011803, ISSN: 2374-7943, DOI: 10.1021/acscentsci.6b00297
DATABASE Registry 19 April 2017 (2017-04-19), ANONYMOUS : "2-Quinolinecarbonitrile, 8-hydroxy-7-nitro- (CA INDEX NAME)", XP093011812, retrieved from STN Database accession no. 2092238-20-3
MCNEIL GERSHON, GERSHON HERMAN, MCNEIL MAYNARD W: "8-Quinolinolsulfonic Acids1", J. ORG. CHEM, vol. 36, no. 23, 1 November 1971 (1971-11-01), pages 3494 - 3496, XP093011804, DOI: 10.1021/jo00822a005
FRESCO JAMES, FREISER HENRY: "Stabilities of Chelates of Certain Substituted 8-Quinolinols", INORGANIC CHEMISTRY, vol. 2, no. 1, 28 February 1963 (1963-02-28), London UK, pages 82 - 85, XP093011806
FREIREICH ET AL., CANCER CHEMOTHER REP, vol. 50, 1966, pages 219
T. W. GREENEG. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY
WANGHUA MALLBEIJING OUHE: "Energy Chemical", article "Technology, Sigma, J&K Scientific, Yishiming, Shanghai Shuya Chemical"
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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