7,8 AND 9-SUBSTITUTED TETRACYCLINE COMPOUNDS

WIPO Patent Application WO2002004404

A3

7,8 and 9-substituted tetracyline compounds of the formula (I) wherein: R<4> and R<4'> are each methyl; R<5> is hydrogen or hydroxyl; R<6> and R<6'> are each independently hydrogen, methyl, or hydroxyl; R<7> is hydrogen, lower alkenyl, lower alkynyl, phenyl, halophenyl, acyl, phenylalkynyl, heteroaryl, or dimethylamino; and R<8> is hydrogen, phenyl, nitrophenyl, halo, or lower alkynyl; and R<9> is hydrogen, amino, acetamide, or lower alkynyl; and provided that at least one of R<7>, R<8>, or R<9> is not hydrogen, methods of treating tretracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.

JP2019031567	METHOD OF TREATING ALVEOLAR BONE LOSS THROUGH USE OF ANTI-SCLEROSTIN ANTIBODIES
WO/1992/020336	NOVEL CHOLESTEROL LOWERING COMPOUNDS

NELSON MARK L
KOZA DARRELL

PCT/US2001/020558

June 13, 2002

June 29, 2001

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TUFTS COLLEGE (US)

A61K31/65; A61P3/10; A61P31/04; C07D319/12; A61P35/00; C07C237/26; C07C245/20; C07C247/18; C07D213/56; C07D241/12; C07D307/54; (IPC1-7): C07C237/26; A61K31/65; A61P31/04

KOZA D J: "SYNTHESIS OF 7-SUBSTITUTED TETRACYCLINE DERIVATIVES", ORGANIC LETTERS, ACS, WASHINGTON, DC, US, vol. 2, no. 6, 2000, pages 815 - 817, XP000943852, ISSN: 1523-7060
KOZA D J: "The synthesis of 8-substituted tetracycline derivatives, the first 8-position carbon-carbon bond", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 26, 24 June 2000 (2000-06-24), pages 5017 - 5020, XP004212489, ISSN: 0040-4039

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