1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I:

I wherein:

R¹ is 8-11 -membered bicyclic heteroaryl optionally substituted with 1-10 R⁴; wherein a carbon atom on an aromatic ring of the heteroaryl form the bond with

R² is selected from the group consisting of H, -OR⁷, 5 -membered heteroaryl optionally substituted with 1-3 R⁸, and -NHR⁹;

R³ is selected from the group consisting of H, -OR¹⁰, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), - heterocyclyl optionally substituted with 1-10 R¹¹, -(5-10 membered heteroaryl) optionally substituted with 1-10 R¹², -(CtLlpCarbocyclyl optionally substituted with 1-12 R¹³, and -NHR¹⁴; with the proviso that R² and R³ are not both H; each R⁴ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted - (C 1-9 haloalkyl), -OR¹⁵, -CH2OH, -heterocyclyl optionally substituted with 1-10 R¹⁶, -heteroaryl optionally substituted with 1-10 R¹⁷, -carbocyclyl optionally substituted with 1-12 R¹⁸, -C(=O)N(R¹⁹)2, and -C(=O)R²⁰; alternatively, two R⁴ attached to the same carbon atom are taken together to form a carbonyl group;

R⁷ is selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2- 9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -(C1-5 alkylene)OR³², and -(CH2)heterocyclyl optionally substituted with 1-10 R²¹; each R⁸ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); R⁹ is selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2- 9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -(Cfblpcarbocyclyl optionally substituted with 1-12 R²², and -heterocyclyl optionally substituted with 1-10 R²³;

R¹⁰ is selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2- 9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R¹¹ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and -(C1-5 alkylene)OR³²; each R¹² is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R¹³ is independently selected from the group consisting of H, halide, unsubstituted - (C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted - (C1-9 haloalkyl);

R¹⁴ is selected from the group consisting of unsubstituted - (C1-9 alkyl), unsubstituted -(C2- 9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -(C1-5 alkylene)OMe, — (Ci- 3 alkylene )_pcarbocyclyl optionally substituted with 1-12 R¹⁷, -(C1-3 alkylene)_pheteroaryl optionally substituted with 1-10 R²⁴, -(C1-3 alkylene )_pphenyl optionally substituted with 1-10 R²⁵, and -(C1-3 alkylene)pheterocyclyl optionally substituted with 1-10 R²⁶, wherein each -(C1-3 alkylene) is, independently, optionally substituted with 1-5 halide and/or 1-5 unsubstituted -(C1-3 alkyl); each R¹⁵ is independently selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and - heterocyclyl optionally substituted with 1-10 R¹⁶; each R¹⁶ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R¹⁷ is independently selected from the group consisting of halide, -OR³¹, - NHC(=O)R³³, -C(=O)R³⁴, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R³⁵; each R¹⁸ is independently selected from the group consisting of halide, unsubstituted — (Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted - (C1-9 haloalkyl); each R¹⁹ are independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); -(CH₂)_pcarbocyclyl optionally substituted with 1-12 R²⁷, -heterocyclyl optionally substituted with 1-10 R²⁸, and -heteroaryl optionally substituted with 1-10 R²⁹; each R²⁰ is -heterocyclyl optionally substituted with 1-10 R²⁸; each R²¹ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R²² is selected from the group consisting of halide, -OMe, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R²³ is independently selected from the group consisting of halide, -OMe, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R¹⁶; each R²⁴ is independently selected from the group consisting of halide, unsubstituted — (Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted - (C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R¹⁶; each R²⁵ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R¹⁶; each R²⁶ is independently selected from the group consisting of halide, -OR³², -C(=O)R³⁶, -SO2Me, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R²⁸; alternatively, two R²⁶ attached to the same carbon atom are taken together to form a carbonyl group; each R²⁷ is independently selected from the group consisting of halide, -OMe, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R²⁸ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R²⁹ is independently selected from the group consisting of halide, unsubstituted — (Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted - (C1-9 haloalkyl); each R³¹ is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C 1-9 haloalkyl), and -(C1-5 alkylene)OR³²; each R³² is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R³³ is independently selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R³⁴ is independently selected from the group consisting of-N(R³⁷)2, and -heterocyclyl optionally substituted with 1-10 R²⁸; each R³⁵ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); alternatively, two R³⁵ attached to the same carbon atom are taken together to form a carbonyl group; each R³⁶ is independently selected from the group consisting of unsubstituted — (C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalky 1); each R³⁷ is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each p is independently 0 or 1 ; wherein each H atom is optionally independently replaced by ²H (D) (deuterium); and with the proviso that Formula I is not a structure selected from the group consisting of:

2. The compound of claim 1, wherein R² is selected from the group consisting of H, - OR⁷, and -NHR⁹.

3. The compound according to any one of claims 1-2, wherein R⁷ is selected from the group consisting of unsubstituted -(C1-3 alkyl) and unsubstituted -(C1-3 haloalkyl).

4. The compound according to any one of claims 1-2, wherein R⁹ is selected from the group consisting of unsubstituted -(C1-3 alkyl) and unsubstituted -(C1-3 haloalkyl).

5. The compound according to any one of claims 1-4, wherein R¹ is 9-10-membered bicyclic heteroaryl optionally substituted with 1-2 R⁴.

6. The compound according to any one of claims 1-5, wherein R¹ is 9-10-membered bicyclic heteroaryl optionally substituted with 1-2 R⁴, wherein 1-2 R⁴ is selected from the group consisting of halide, unsubstituted -(C1-3 alkyl), or unsubstituted -(C1-3 haloalkyl).

7. The compound according to any one of claims 1-6, wherein R¹ is selected from the group consisting of: optionally substituted with 1-2 R⁴.

8. The compound according to any one of claims 1-7, wherein R¹ selected from the group consisting of: s

9. The compound according to any one of claims 1-8, wherein R¹ selected from the group consisting of:

10. The compound according to any one of claims 1-9, wherein R³ is selected from the group consisting of-carbocyclyl optionally substituted with 1-2 R¹³ and -NHR¹⁴.

11. The compound according to any one of claims 1-10, wherein R¹⁴ is selected from the group consisting of-carbocyclyl optionally substituted with 1-5 R¹⁷ and -heterocyclyl optionally substituted with 1-5 R²⁶.

12. A compound, or a pharmaceutically acceptable salt thereof, of Formula Ic: wherein:

R¹ is selected from the heteroaryl group consisting of: wherein a carbon atom on an aromatic ring of the heteroaryl form the bond with each R⁴ is independently selected from the group consisting of halide, unsubstituted — (Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted - (C 1-9 haloalkyl), -OR¹⁵, -CH2OH, -heterocyclyl optionally substituted with 1-10 R¹⁶, -heteroaryl optionally substituted with 1-10 R¹⁷, -carbocyclyl optionally substituted with 1-12 R¹⁸, -C(=O)N(R¹⁹)2, and -C(=O)R²⁰; alternatively, two R⁴ attached to the same carbon atom are taken together to form a carbonyl group; each R¹⁵ is independently selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and - heterocyclyl optionally substituted with 1-10 R¹⁶; each R¹⁶ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R¹⁷ is independently selected from the group consisting of halide, -OR³¹, - NHC(=O)R³³, -C(=O)R³⁴, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R³⁵; each R¹⁸ is independently selected from the group consisting of halide, unsubstituted — (Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted — (C1-9 haloalkyl); each R¹⁹ are independently selected from the group consisting of H, unsubstituted — (C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted — (C1-9 haloalkyl); -(CFblpCarbocyclyl optionally substituted with 1-12 R²⁷, -heterocyclyl optionally substituted with 1-10 R²⁸, and -heteroaryl optionally substituted with 1-10 R²⁹; each R²⁰ is -heterocyclyl optionally substituted with 1-10 R²⁸; each R²⁷ is independently selected from the group consisting of halide, -OMe, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R²⁸ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R²⁹ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R³⁰ is independently selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R³¹ is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C 1-9 haloalkyl), and -(C1-5 alkylene)OR³²; each R³² is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted — (C1-9 haloalkyl); each R³³ is independently selected from the group consisting of unsubstituted — (C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R³⁴ is independently selected from the group consisting of-N(R³⁷)2, and -heterocyclyl optionally substituted with 1-10 R²⁸; each R³⁵ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); alternatively, two R³⁵ attached to the same carbon atom are taken together to form a carbonyl group; each R³⁷ is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each p is independently 0 or 1 ; and wherein each H atom is optionally independently replaced by ²H (D) (deuterium).

13. The compound of claim 12, wherein R¹ is selected from the group consisting of: optionally substituted with 1-2 R⁴.

14. The compound according to any one of claims 12-13, wherein R¹ is selected from the group consisting of: s

15. A compound, or a pharmaceutically acceptable salt thereof, of Formula I: wherein:

R¹ is selected from the group consisting of phenyl substituted with 1 -5 R⁵, 6-membered heteroaryl optionally substituted optionally substituted with 1 -4 R⁶;

R² is selected from the group consisting of H, -OR⁷, 5 -membered heteroaryl optionally substituted with 1-3 R⁸, and -NHR⁹,

R³ is selected from the group consisting of H, -OR¹⁰, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), - heterocyclyl optionally substituted with 1-10 R¹¹, -(5-10 membered heteroaryl) optionally substituted with 1-10 R¹², -(CFFlpCarbocyclyl optionally substituted with 1-12 R¹³, and -NHR¹⁴; with the proviso that either R² or R³ is H but R² and R³ are not both H; each R⁵ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -OR¹⁵, -CH2OH, -heterocyclyl optionally substituted with 1-10 R¹⁶, -heteroaryl optionally substituted with 1-10 R¹⁷, -carbocyclyl optionally substituted with 1-12 R¹⁸, -C(=O)N(R¹⁹)2, and -C(=O)R²⁰; each R⁶ is independently selected from the group consisting of halide, unsubstituted — (Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -OR^15a, -CH2OH, -heterocyclyl optionally substituted with 1-10 R^16a, -heteroaryl optionally substituted with 1-10 R^17a, -carbocyclyl optionally substituted with 1-12 R^18a, -C(=O)N(R^19a)2, and -C(=O)R^20a;

R⁷ is selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2- 9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalky 1), -(C1-5 alkylene)OR³², and -(CH2)heterocyclyl optionally substituted with 1-10 R²¹; each R⁸ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl);

R⁹ is selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2- 9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -(Cfblpcarbocyclyl optionally substituted with 1-12 R²², and -heterocyclyl optionally substituted with 1-10 R²³;

R¹⁰ is selected from the group consisting of unsubstituted - (C1-9 alkyl), unsubstituted -(C2- 9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R¹¹ is independently selected from the group consisting of halide, unsubstituted — (Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted - (C 1-9 haloalkyl), and -(C1-5 alkylene)OR³²; each R¹² is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R¹³ is independently selected from the group consisting of H, halide, unsubstituted - (C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl);

R¹⁴ is selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted - (C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C 1-9 haloalkyl), -(C1-5 alkylene)OMe, — (C1-3 alkylene)_pcarbocyclyl optionally substituted with 1-12 R¹⁷, -(C1-3 alkylene)_pheteroaryl optionally substituted with 1-10 R²⁴, -(C1-3 alkylene)_pphenyl optionally substituted with 1-10 R²⁵, and -(C1-3 alkylene)_pheterocyclyl optionally substituted with 1-10 R²⁶, wherein each -(C1-3 alkylene) is, independently, optionally substituted with 1-5 halide and/or 1-5 unsubstituted -(C1-3 alkyl); each R¹⁵ is independently selected from the group consisting of unsubstituted — (C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted — (C1-9 haloalkyl), and - heterocyclyl optionally substituted with 1-10 R¹⁶; each R^15a is independently selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and - heterocyclyl optionally substituted with 1-10 R^16a; each R¹⁶ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R^16a is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R¹⁷ is independently selected from the group consisting of halide, -OR³¹, - NHC(=O)R³³, -C(=O)R³⁴, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R³⁵; each R^17a is independently selected from the group consisting of halide, -OMe, unsubstituted - (C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R¹⁸ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R^18a is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R¹⁹ are independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); -(CFblpCarbocyclyl optionally substituted with 1-12 R²⁷, -heterocyclyl optionally substituted with 1-10 R²⁸, and -heteroaryl optionally substituted with 1-10 R²⁹; each R^19a are independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); -(Cfblpcarbocyclyl optionally substituted with 1-12 R^27a, -heterocyclyl optionally substituted with 1-10 R^28a, and -heteroaryl optionally substituted with 1-10 R^29a; each R²⁰ is -heterocyclyl optionally substituted with 1-10 R²⁸; each R^20a is -heterocyclyl optionally substituted with 1-10 R^28a;

551 each R²¹ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R²² is independently selected from the group consisting of halide, -OMe, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R²³ is independently selected from the group consisting of halide, -OMe, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R¹⁶; each R²⁴ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R¹⁶; each R²⁵ is independently selected from the group consisting of halide, unsubstituted — (Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted - (C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R¹⁶; each R²⁶ is independently selected from the group consisting of halide, -OR³², -C(=O)R³⁶, -SO2Me, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R²⁸; alternatively, two R²⁶ attached to the same carbon atom are taken together to form a carbonyl group; each R²⁷ is independently selected from the group consisting of halide, -OMe, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R^27a is independently selected from the group consisting of halide, -OMe, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R²⁸ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R^28a is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted — (C1-9 haloalkyl); each R²⁹ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R^29a is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R³¹ is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C 1-9 haloalkyl), and -(C1-5 alkylene)OR³²; each R³² is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each R³³ is independently selected from the group consisting of unsubstituted — (C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R³⁴ is independently selected from the group consisting of-N(R³⁷)2, and -heterocyclyl optionally substituted with 1-10 R²⁸; each R³⁵ is independently selected from the group consisting of halide, unsubstituted -(Cu 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); alternatively, two R³⁵ attached to the same carbon atom are taken together to form a carbonyl group; each R³⁶ is independently selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C 1-9 haloalkyl); each R³⁷ is independently selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), and unsubstituted -(C1-9 haloalkyl); each p is independently 0 or 1 ; wherein each H atom is optionally independently replaced by ²H (D) (deuterium); and with the proviso that Formula I is not a structure selected from the group consisting of:

16. The compound of claim 15, wherein R² is selected from the group consisting of H, - OR⁷, and -NHR⁹.

17. The compound according to any one of claims 15-16, wherein R⁷ is selected from the group consisting of unsubstituted -(C1-3 alkyl) and unsubstituted -(C1-3 haloalkyl).

18. The compound according to any one of claims 15-16, wherein R⁹ is selected from the group consisting of unsubstituted -(C1-3 alkyl) and unsubstituted -(C1-3 haloalkyl).

19. The compound according to any one of claims 15-18, wherein R¹ is selected from the group consisting of 6-membered heteroaryl optionally substituted optionally substituted with 1-2 R⁶.

20. The compound according to any one of claims 15-19, wherein R¹ is selected from the group consisting of pyridine and optionally substituted with one -OR^15a or one unsubstituted -(C1-3 alkyl).

21. The compound according to any one of claims 15-20, wherein R¹ is selected from the group consisting optionally substituted with one -OR^15a or one unsubstituted -(C1-3 alkyl).

22. The compound according to any one of claims 15-21, wherein R³ is selected from the group consisting of unsubstituted -(C1-5 alkyl) and -NHR¹⁴.

23. The compound according to any one of claims 1-22, wherein the compound of Formula I is selected from the group consisting of: N-(2-fluoro-2-methylpropyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1];

5-(2,4-dimethoxyphenyl)-N-(l-(methylsulfonyl)piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2];

5-(2-((2-fhioro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-methylpyridin- 2(lH)-one [3];

5-(2-((4,4-difhiorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-methylpyridin-2(lH)- one [4]; 5-(6-(difluoromethyl)pyridin-3-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [5];

N-(2-fluoro-2-methylpropyl)-5-(6-methoxypyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[6];

5-(6-(difluoromethoxy)pyridin-3-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [7];

5-(6-methoxypyridin-3-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4- amine [8];

N-(2-fluoro-2-methylpropyl)-5-(2-methoxypyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [9];

5 -(2-(((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)isoindolin-l-one [10];

2-methyl-6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)benzo [d]thiazole [11];

6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]thiazole [12];

2-methyl-6-(2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)benzo[d]thiazole [13] ;

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]thiazole [14];

6-(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-2 -methylbenzo [d]thiazole [15] ;

6-(2 -(cy clobutylmethyl)-7H-py rrolo [2,3 -d]pyrimidin-5 -y 1) -2 -methylbenzo [d]thiazole [16];

5 -(2 -methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [17];

N-methyl-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [18];

N-ethyl-5 -(2 -methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [19];

N-isopropyl-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [20];

N-isobutyl-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [21]; 5-(2-methylbenzo[d]thiazol-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [22]; (S)-N-(sec-butyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [23];

N-(2-fluoro-2-methylpropyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [24];

N-(2,2-difluoropropyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[25];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[26];

(R)-5-(2-methylbenzo[d]thiazol-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [27]; (S)-5-(2-methylbenzo[d]thiazol-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [28];

5 -(2 -methylbenzo [d]thiazol-6-yl)-N-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [29];

(S)-N-(l-methoxypropan-2-yl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [30];

6-(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-2 -methylbenzo [d]thiazole [31 ] ;

N-((l-fluorocyclopropyl)methyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [32];

(R)-N-(l-cyclopropylethyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [33];

5-(2-methylbenzo[d]thiazol-6-yl)-N-((l-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [34];

5-(2-methylbenzo[d]thiazol-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [35];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [36];

N-(3 ,3 -difluorocyclobutyl) -5 -(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [37];

N-((l-fluorocyclobutyl)methyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [38];

N-(4,4-difluorocyclohexyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [39];

N-(cri-4-methoxycyclohexyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [40];

N-((l-fluorocyclohexyl)methyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [41];

N-((4,4-difluorocyclohexyl)methyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [42];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(l-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [43];

5-(2-methylbenzo[d]thiazol-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [44];

556 5-(2-methylbenzo[d]thiazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [45];

5 -(2 -methylbenzo [d]thiazol-6-yl)-N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [46];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [47];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [48];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [49];

5-(2-methylbenzo[d]thiazol-6-yl)-N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [50] ;

2-methyl-6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzo[d]thiazole [51];

2-methyl-6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzo[d]thiazole [52];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [53];

N-(2-fluoro-2-methylpropyl)-5 -(2-methylthiazolo [5 ,4-b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [54];

2-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)thieno [3 ,2-c]pyridine [55] ;

2-(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)thieno [3 ,2-c]pyridine [56] ;

2-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)thieno[3,2-c]pyridine [57];

2-(2-cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)thieno [3 ,2-c]pyridine [58] ;

2-(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)thieno [3 ,2-c]pyridine [59] ;

2-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)thieno[3,2-c]pyridine [60];

5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [61] ;

N-methyl-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [62] ;

N-ethyl-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [63] ;

N-isopropyl-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [64] ;

N-isobutyl-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [65];

N-neopentyl-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [66]; (S)-N-(sec-butyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [67];

N-(2-fluoro-2-methylpropyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [68];

N-(2,2-difluoropropyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [69];

557 5-(thieno[3,2-c]pyridin-2-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [70];

(R)-5 -(thieno [3 ,2-c]pyridin-2-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [71];

(S)-5-(thieno[3,2-c]pyridin-2-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [72];

5 -(thieno [3 ,2-c]pyridin-2-yl)-N-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [73] ;

(S)-N-(l-methoxypropan-2-yl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [74];

2-(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)thieno [3 ,2-c]pyridine [75] ;

N-((l-fluorocyclopropyl)methyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [76];

(R)-N-(l-cyclopropylethyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[77];

N-((l-methylcyclopropyl)methyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [78];

5 -(thieno [3 ,2-c]pyridin-2-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [79];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [80];

N-(3 ,3 -difluorocyclobutyl) -5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [81];

N-(( 1 -fluorocyclobutyl)methyl)-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [82];

N-(4,4-difluorocyclohexyl)-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine

[83];

N-(cri-4-methoxycyclohexyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[84];

N-((l-fluorocyclohexyl)methyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [85];

N-((4,4-difluorocyclohexyl)methyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [86];

N-(l-methylpiperidin-4-yl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[87]; N-((l-methylpiperidin-4-yl)methyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [88];

N-(tetrahydro-2H-pyran-4-yl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [89];

N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [90];

N-(pyridin-4-yl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [91];

N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [92];

N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -y 1) -5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [93];

N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [94] ;

2-(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)thieno [3 ,2-c]pyridine [95] ;

2-(4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)thieno [3 ,2-c]pyridine [96] ;

N-(/ra«5-4-morpholinocyclohexyl)-5-(thieno[3,2-c]pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4- amine [97];

2-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)thiazolo [5,4-b]pyridine [98] ;

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [99] ;

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidine [100] ;

5-(imidazo[l,2-a]pyridin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidine [101];

2-cyclopropyl-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [102];

2-cyclobutyl-5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [103] ;

2-(cyclobutyhnethyl)-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [104];

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [105] ;

5-(imidazo[l,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [106];

N-ethyl-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [107];

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [108] ;

5-(imidazo[l,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [109];

5-(imidazo[l,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [110];

(S)-N-(sec-butyl)-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [111];

N-(2-fluoro-2-methylpropyl)-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[112]; N-(2,2-difluoropropyl)-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[113];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[114];

(R)-5-(imidazo[l,2-a]pyridin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [115];

(S)-5-(imidazo[l,2-a]pyridin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [116];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [117];

(S)-5-(imidazo[l,2-a]pyridin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [118];

2 -ethoxy-5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [119];

N-((l-fluorocyclopropyl)methyl)-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [120];

(R)-N-( 1 -cyclopropylethyl)-5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [121];

5-(imidazo[l,2-a]pyridin-6-yl)-N-((l-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [122];

5 -(imidazo [ 1 ,2-a]pyridin-6-y 1) -N-(( 1 -(trifluoromethyl)cyclopropyl)methy 1) -7H-pyrrolo [2,3- d]pyrimidin-2-amine [123];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [124];

N-(3 ,3 -difluorocyclobutyl) -5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [125];

N-(( 1 -fluorocyclobutyl)methyl)-5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [126];

N-(4,4-difluorocyclohexyl)-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [127];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [128];

N-(( 1 -fluorocyclohexyl)methyl)-5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [129]; N-((4,4-difluorocyclohexyl)methyl)-5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [130];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(l-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [131];

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [132];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [133];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-l-yl)phenyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [134];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [135];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [136];

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [137];

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [138];

6-(5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline [139];

5-(imidazo[ 1 ,2-a]pyridin-6-yl)-4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine [140] ;

5-(imidazo[l,2-a]pyridin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4- amine [141];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [142] ;

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo[2,3-d]pyrimidine [143];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidine [144];

2-cyclopropyl-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [145] ;

2-cyclobutyl-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [146];

2-(cyclobutylmethyl)-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [147] ;

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [148] ;

5-(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3 -d]pyrimidin-2-amine [149] ;

N-ethyl-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [150] ;

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [151];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [152];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [153]; (S)-N-(sec-butyl)-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [154];

N-(2-fluoro-2-methylpropyl)-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [155];

N-(2,2-difluoropropyl)-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [156];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [157];

(R)-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [158];

(S)-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [159];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [160];

(S)-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [161];

2-ethoxy-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [162];

N-(( 1 -fluorocyclopropyl)methyl)-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [163];

(R)-N-( 1 -cyclopropylethyl)-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [164];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((l-methylcyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [165];

5-(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [166];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [167];

N-(3 ,3 -difluorocyclobutyl) -5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [168];

N-(( 1 -fluorocyclobutyl)methyl)-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [169];

N-(4,4-difluorocyclohexyl)-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [170]; 5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [171];

N-(( 1 -fluorocyclohexyl)methyl)-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [172];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [173];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [174];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [175];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [176];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [177];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [178];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [179];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [180];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [181];

6-(5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [182] ;

5-(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo[2, 3- d]pyrimidine [183];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [184];

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [185] ;

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo[2,3-d]pyrimidine [186];

5 -(8 -fluoroimidazo [ 1 , 2-a]pyridin-6-yl)-2 -isobutyl -4-methoxy-7H-pyrrolo [2,3 -d]pyrimidine [187] ;

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidine

[188];

2-cyclopropyl-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [189];

2-cyclobutyl-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [190]; 2-(cyclobutylmethyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [191];

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [192] ;

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [193];

N-ethyl-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [194];

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [195] ;

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [196];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [197];

(S)-N-(sec-butyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [198];

N-(2-fluoro-2-methylpropyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [199];

N-(2,2-difluoropropyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [200];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [201];

(R)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [202];

(S)-5-(8-fluoroimidazo[ 1 ,2-a]pyridin-6-yl)-N-( 1 , 1 , 1 -trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [203];

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [204];

(S)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [205];

2-ethoxy-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [206];

N-(cyclopropylmethyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [207];

N-((l-fluorocyclopropyl)methyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [208];

(R)-N-(l-cyclopropylethyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [209];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((l-methylcyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [210];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [211]; N-(2-cyclopropyl-2,2-difluoroethyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [212];

N-(3,3-difluorocyclobutyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [213];

N-((l-fluorocyclobutyl)methyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [214];

N-(4,4-difluorocyclohexyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [215];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [216];

N-((l-fluorocyclohexyl)methyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [217];

N-((4,4-difluorocyclohexyl)methyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [218];

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [219];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [220];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [221];

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [222];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [223];

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [224] ;

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [225] ;

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [226] ;

6-(5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [227] ;

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidine [228]; 5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [229];

5 -(8-fluoro-2-methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [230] ;

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo[2,3-d]pyrimidine [231];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidine [232];

2-cyclopropyl-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine

[233];

2-cyclobutyl-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine

[234];

2-(cyclobutylmethyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [235];

5 -(8 -fluoro-2-methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [236] ;

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[237];

N-ethyl-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[238];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [239];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[240];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [241];

(S)-N-(sec-butyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [242];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [243];

N-(2,2-difluoropropyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [244];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [245];

(R)-5-(8-fluoro-2-methylimidazo[ 1 ,2-a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [246] ; (S)-5 -(8-fluoro-2-methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [247] ;

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [248];

(S)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [249];

2-ethoxy-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [250];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-fluorocyclopropyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [251];

(R)-N-(l-cyclopropylethyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [252];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-methylcyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [253] ;

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [254] ;

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [255] ;

N-(3,3-difluorocyclobutyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [256];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-fluorocyclobutyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [257];

N-(4,4-difluorocyclohexyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [258];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [259];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-fluorocyclohexyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [260] ;

N-((4,4-difluorocyclohexyl)methyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [261];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(l-methylpiperidin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [262];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [263] ; 5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [264];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-l-yl)phenyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [265] ;

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [266];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [267] ;

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [268] ;

5 -(8 -fluoro-2-methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 - yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [269];

6-(5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline

[270];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidine [271];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-4-amine [272] ;

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [273] ;

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidine [274] ;

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidine [275];

2-cyclopropyl-5 -(8-fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine

[276];

2-cyclobutyl-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine

[277];

2-(cyclobutylmethyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [278];

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [279] ;

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine

[280];

N-ethyl-5 -(8-fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine

[281]; 5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [282];

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [283];

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [284];

(S)-N-(sec-butyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [285];

N-(2-fluoro-2-methylpropyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [286];

N-(2,2-difluoropropyl)-5 -(8-fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [287];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [288];

(R)-5 -(8-fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [289] ;

(S)-5 -(8-fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [290] ;

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [291];

(S)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [292];

2 -ethoxy-5 -(8-fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [293] ;

5 -( 8 -fluoro-3 -methylimidazo [1,2 -a]pyridin-6-y 1) -N-(( 1 -fluorocyclopropyl)methyl) -7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [294] ;

(R)-N-(l-cyclopropylethyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [295];

5 -(8 -fluoro-3 -methylimidazo [1,2 -a]pyridin-6-y 1) -N-(( 1 -methylcyclopropyl)methyl) -7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [296] ;

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [297] ;

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [298] ;

569 N-(3,3-difluorocyclobutyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [299];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-fluorocyclobutyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [300];

N-(4,4-difluorocyclohexyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [301];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [302];

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-(( 1 -fluorocyclohexyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [303] ;

N-((4,4-difluorocyclohexyl)methyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [304] ;

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(l-methylpiperidin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [305];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [306] ;

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [307];

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [308] ;

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [309];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [310];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [311];

5 -(8 -fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 - yl)methy 1) -7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [312];

6-(5 -(8-fluoro-3 -methylimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline

[313];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidine [314];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-4-amine [315]; 5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [316];

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidine [317];

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 - d]pyrimidine [318];

2-cyclopropyl-5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine

[319];

2-cyclobutyl-5 -(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine

[320];

2-(cyclobutylmethyl)-5 -(3 -(difluoromethyl)imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidine [321];

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [322] ;

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[323];

5 -(3 -(difluoromethyl)imidazo [ 1 ,2-a]pyridin-6-yl)-N-ethyl-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine

[324];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [325];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [326];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [327];

(S)-N-(sec-butyl)-5-(3-(difluorornethyl)imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [328];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [329];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [330];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [331];

(R)-5 -(3 -(difluoromethyl)imidazo [ 1 ,2-a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [332] ;

(S)-5 -(3 -(difluoromethyl)imidazo [ 1 ,2-a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [333] ; 5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [334];

(S)-5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [335];

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidine [336] ;

5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(( 1 -fluorocyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [337] ;

(R)-N-(l-cyclopropylethyl)-5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [338];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(( 1 -methylcyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [339] ;

5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [340] ;

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [341];

N-(3 ,3 -difluorocyclobutyl) -5 -(3 -(difluoromethyl)imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [342];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(( 1 -fluorocyclobutyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [343] ;

N-(4,4-difluorocyclohexyl)-5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [344];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [345];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(( 1 -fluorocyclohexyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [346] ;

N-((4,4-difluorocyclohexyl)methyl)-5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [347] ;

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(l-methylpiperidin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [348];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [349] ;

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [350]; 5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(3-(4-methylpiperazin- 1 -yl)phenyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [351];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [352];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [353] ;

5-(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [354] ;

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-a]pyridin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 - yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [355];

6-(5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline

[356];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidine [357];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-((/ra«5-4-morpholinocyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-4-amine [358] ;

2-cyclopropyl-5 -(3 -(difluoromethyl)-8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidine [359];

(8-fluoro-6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridin-3 -yl)methanol [360] ;

(8-fluoro-6-(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridin-3 -yl)methanol [361];

(8-fluoro-6-(2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridin-3 - yl)methanol [362];

(6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[l,2-a]pyridin-3- yl)methanol [363];

(6-(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-8-fluoroimidazo [ 1 ,2-a]pyridin-3 -yl)methanol [364];

(6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[l,2-a]pyridin-3- yl)methanol [365];

(6-(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-8-fluoroimidazo [ 1 ,2-a]pyridin-3 -yl)methanol [366];

(8-fluoro-6-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2-a]pyridin-3- yl)methanol [367]; (6-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[l,2-a]pyridin-3- yl)methanol [368];

(8-fluoro-6-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2-a]pyridin-3- yl)methanol [369];

(8-fluoro-6-(2-(isobutylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridin-3 - yl)methanol [370];

(8-fluoro-6-(2-(neopentylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridin-3 - yl)methanol [371];

(S)-(6-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[l,2-a]pyridin-3- yl)methanol [372];

(8-fluoro-6-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridin-3-yl)methanol [373];

(6-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[l,2- a]pyridin-3-yl)methanol [374];

(8-fluoro-6-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridin-3-yl)methanol [375];

(R)-(8-fluoro-6-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [376] ;

(S)-(8 -fluoro-6-(2-(( 1,1,1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)imidazo[ 1 ,2-a]pyridin-3-yl)methanol [377] ;

(8-fluoro-6-(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [1,2- a]pyridin-3-yl)methanol [378];

(S)-(8-fluoro-6-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [379] ;

(6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[l,2-a]pyridin-3-yl)methanol

[380];

(8-fluoro-6-(2-(((l-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3-yl)methanol [381] ;

(R)-(6-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[l,2- a]pyridin-3-yl)methanol [382];

(8-fluoro-6-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [383] ;

(8-fluoro-6-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [384] ; (6-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8- fluoroimidazo [ 1 ,2-a]pyridin-3 -yl)methanol [385] ;

(6-(2-((3 ,3 -difluorocyclobutyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-8-fluoroimidazo [1,2- a]pyridin-3-yl)methanol [386];

(8-fluoro-6-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [387] ;

(6-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[l,2- a]pyridin-3-yl)methanol [388];

(8-fluoro-6-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridin-3-yl)methanol [389];

(8-fluoro-6-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [390] ;

(6-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8- fluoroimidazo [ 1 ,2-a]pyridin-3 -yl)methanol [391] ;

(8-fluoro-6-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridin-3-yl)methanol [392];

(8-fluoro-6-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [393] ;

(8-fluoro-6-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridin-3-yl)methanol [394];

(8-fluoro-6-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [395] ;

(8-fluoro-6-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2-a]pyridin-3- yl)methanol [396];

(8-fluoro-6-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [397] ;

(8-fluoro-6-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [398] ;

(8-fluoro-6-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridin-3 -yl)methanol [399] ;

(8-fluoro-6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2-a]pyridin-3- yl)methanol [400];

(8-fluoro-6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridin-3-yl)methanol [401]; (8-fluoro-6-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [402] ;

2-cyclopropyl-5 -(8-fluoro-3 -( 1 -methylpiperidin-4-yl)imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidine [403];

N-(2,2-difluoroethyl)-6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [404];

N-(2,2-difluoroethyl)-6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2-a]pyridine-3- carboxamide [405];

N-(2,2-difluoroethyl)-6-(2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [1,2- a]pyridine -3 -carboxamide [406];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[l,2-a]pyridine- 3 -carboxamide [407];

6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[l,2-a]pyridine- 3 -carboxamide [408];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[l,2- a]pyridine -3 -carboxamide [409];

6-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[l,2-a]pyridine-3- carboxamide [410];

N-(2,2-difluoroethyl)-6-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridine -3 -carboxamide [411];

N-(2,2-difluoroethyl)-6-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridine -3 -carboxamide [412];

N-(2,2-difluoroethyl)-6-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridine -3 -carboxamide [413];

N-(2,2-difluoroethyl)-6-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridine -3 -carboxamide [414];

N-(2,2-difluoroethyl)-6-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridine -3 -carboxamide [415];

(S)-6-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[l,2- a]pyridine -3 -carboxamide [416];

N-(2,2-difluoroethyl)-6-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [417];

N-(2,2-difluoroethyl)-6-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[l,2-a]pyridine-3-carboxamide [418]; N-(2,2-difluoroethyl)-6-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[l,2-a]pyridine-3-carboxamide [419];

(R)-N-(2,2-difluoroethyl)-6-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [420] ;

(S)-N-(2,2-difluoroethyl)-6-(2-(( 1,1,1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-

5 -yl)imidazo [1,2 -a]pyridine-3 -carboxamide [421];

N-(2,2-difluoroethyl)-6-(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [422] ;

(S)-N-(2,2-difluoroethyl)-6-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [423] ;

N-(2,2-difluoroethyl)-6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2-a]pyridine-3- carboxamide [424];

N-(2,2-difluoroethyl)-6-(2-(((l-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [425] ;

(R)-6-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)imidazo [1,2 -a]py ridine -3 -carboxamide [426] ;

N-(2,2-difluoroethyl)-6-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [427] ;

N-(2,2-difluoroethyl)-6-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [428] ;

6-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)imidazo [1,2 -a]py ridine -3 -carboxamide [429] ;

6-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)imidazo [1,2 -a]py ridine -3 -carboxamide [430] ;

N-(2,2-difluoroethyl)-6-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [431 ] ;

6-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)imidazo [1,2 -a]py ridine -3 -carboxamide [432] ;

N-(2,2-difluoroethyl)-6-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [433] ;

N-(2,2-difluoroethyl)-6-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [434] ;

6-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)imidazo [1,2 -a]py ridine -3 -carboxamide [435] ; N-(2,2-difluoroethyl)-6-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[l,2-a]pyridine-3-carboxamide [436];

N-(2,2-difluoroethyl)-6-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [437] ;

N-(2,2-difluoroethyl)-6-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [438] ;

N-(2,2-difluoroethyl)-6-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [439] ;

N-(2,2-difluoroethyl)-6-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [1,2- a]pyridine -3 -carboxamide [440];

N-(2,2-difluoroethyl)-6-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)imidazo [1,2 -a]pyridine-3 -carboxamide [441];

N-(2,2-difluoroethyl)-6-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [442] ;

N-(2,2-difluoroethyl)-6-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [443] ;

N-(2,2-difluoroethyl)-6-(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)imidazo [1,2- a]pyridine -3 -carboxamide [444];

N-(2,2-difluoroethyl)-6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [445] ;

N-(2,2-difluoroethyl)-6-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [446] ;

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [447] ;

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidine [448] ;

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo[2,3 -d]pyrimidine [449] ;

2 -cyclopropyl-5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d] pyrimidine [450] ;

2-cyclobutyl-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [451];

2-(cyclobutylmethyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [452];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [453] ;

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [454];

N-ethyl-5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [455] ;

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [456];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [457] ;

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-neopentyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [458] ; (S)-N-(sec-butyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [459];

N-(2-fluoro-2-methylpropyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [460];

N-(2,2-difluoropropyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[461];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[462];

(R)-5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [463];

(S)-5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-

2-amine [464];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [465];

(S)-5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [466];

2 -ethoxy-5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [467] ;

N-(( 1 -fluorocyclopropyl)methyl)-5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [468];

(R)-N-(l-cyclopropylethyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [469];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-(( 1 -methylcyclopropyl)methyl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [470];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [471];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [472];

N-(3 ,3 -difluorocyclobutyl) -5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [473];

N-((l-fluorocyclobutyl)methyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [474];

N-(4,4-difluorocyclohexyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [475];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [476]; N-(( 1 -fluorocyclohexyl)methyl)-5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [477];

N-((4,4-difluorocyclohexyl)methyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [478];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [479];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [480];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [481];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [482];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [483];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [484];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [485];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [486] ;

6-(5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [487] ;

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo [2,3 -d]pyrimidine [488];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [489];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-2-neopentyl-7H-pyrrolo [2,3 -d]pyrimidine [490] ;

5-(imidazo[l,2-a]pyrazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [491];

N-(2-fluoro-2-methylpropyl)-5-(2-methyl-2H-indazol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [492];

5-(4-fluoro-l,2-dimethyl-lH-benzo[d]imidazol-6-yl)-N-((l-methylazetidin-3-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [493] ;

2-(azetidin-l-yl)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [494];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [495]; 5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-2-isobutyl-7H-pyrrolo[2,3- d]pyrimidine [496];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-2-isobutyl-4-methoxy-7H- pyrrolo[2,3-d]pyrimidine [497];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-2-(3,3,3-trifluoropropyl)-7H- pyrrolo[2,3-d]pyrimidine [498];

2-cyclopropyl-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [499]; and

2-cyclobutyl-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [500]; or a pharmaceutically acceptable salt thereof.

24. The compound according to any one of claims 1-22, wherein the compound of Formula I is selected from the group consisting of: 2-(cyclobutyhnethyl)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidine [501];

5-(4-fhioro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [502];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-methyl-7H-pyrrolo[2,3- d]pyrimidin-2-amine [503];

N-ethyl-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [504];

5-(4-fhioro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-isopropyl-7H-pyrrolo[2,3- d]pyrimidin-2-amine [505];

5-(4-fhioro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-isobutyl-7H-pyrrolo[2,3- d]pyrimidin-2-amine [506];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-neopentyl-7H-pyrrolo[2,3- d]pyrimidin-2-amine [507];

(S)-N-(sec-butyl)-5-(4-fhioro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [508];

5-(4-fhioro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(2-fluoro-2-methylpropyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [509] ;

N-(2,2-difhroropropyl)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [510];

5-(4-fhioro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [511]; (R)-5-(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [512];

(S)-5-(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-( 1 , 1 , 1 -trifluoropropan -2 -yl)-

7H-pyrrolo[2,3-d]pyrimidin-2-amine [513];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(3,3,3-trifluoropropyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [514];

(S)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(l-methoxypropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [515];

2-ethoxy-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [516];

5-(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-(( 1 -fluorocyclopropyl)methyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [517];

(R)-N-( 1 -cyclopropylethyl)-5-(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [518];

5-(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-(( 1 -methylcyclopropyl)methyl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [519];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-((l-

(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [520];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6- yl)-7H-py rrolo [2,3 -d]py rimidin-2-amine [521];

N-(3,3-difluorocyclobutyl)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [522] ;

5-(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-(( 1 -fluorocyclobutyl)methyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [523] ;

N-(4,4-difluorocyclohexyl)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [524] ;

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(cis-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [525] ;

5-(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-(( 1 -fluorocyclohexyl)methyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [526] ;

N-((4,4-difluorocyclohexyl)methyl)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [527];

5-(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [528] ;

582 -(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-((l-methylpiperidin-4- yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [529]; -(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [530] ; -(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-(3-(4-methylpiperazin- 1 - yl)phenyl)-7H-py rrolo [2,3 -d]pyrimidin-2-amine [531]; -(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [532]; -(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-(2-(4-methylpiperazin- 1 - yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [533]; -(4-fluoro- 1 -isopropyl -2 -methyl- lH-benzo[d]imidazol-6-yl)-N-(6-(4-methylpiperazin- 1 - yl)pyridin-3 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [534] ; -(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-((6-(4-methylpiperazin-l- yl)pyridin-3 -yl)methyl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [535] ; -(5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)quinoline [536]; -(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-4-(l-methyl-lH-pyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidine [537]; -(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)- 7H-pyrrolo [2,3 -d]pyrimidin-4-amine [538] ; -cyclopropyl-5-(5-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [539]; -cyclopropyl-5-(7-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [540]; -(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [541]; -(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-2-isobutyl-7H- pyrrolo[2,3-d]pyrimidine [542]; -(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- IH-benzo [d]imidazol-6-yl)-2-(3 ,3 ,3 - trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidine [543]; -cyclopropyl-5 -(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- IH-benzo [d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidine [544]; -cyclobutyl-5 -(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- IH-benzo [d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidine [545]; 2-(cyclobutylmethyl)-5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6- yl)-7H-py rrolo [2,3 -d]pyrimidine [546] ;

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [547];

5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-methyl-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [548] ;

N-ethyl-5 -(4-fluoro-2-methyl- 1 -( 1 -methylpiperidin-4-yl)- IH-benzo [d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [549] ;

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-isopropyl-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [550] ;

5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-isobutyl-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [551];

5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-neopentyl-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [552] ;

(S)-N-(sec-butyl)-5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [553] ;

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(2-fluoro-2- methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [554];

N-(2,2-difluoropropyl)-5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [555];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(2,2,2- trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [556];

(R)-5 -(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- IH-benzo [d]imidazol-6-yl)-N-( 1,1,1- trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [557];

(S)-5 -(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- IH-benzo [d]imidazol-6-yl)-N-( 1,1,1- trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [558];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(3,3,3- trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [559];

(S)-5 -(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- IH-benzo [d]imidazol-6-yl)-N-( 1 - methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [560];

2-ethoxy-5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidine [561];

5-(4-fluoro-2-methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-(( 1 - fluorocyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [562]; (R)-N-( 1 -cyclopropylethyl)-5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- 1H- benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [563];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-((l- methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [564];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-((l- (trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [565];

N-(2 -cyclopropyl -2, 2-difluoroethyl)-5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin -4-yl)- 1H- benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [566];

N-(3,3-difluorocyclobutyl)-5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin -4-yl)- 1H- benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [567];

5-(4-fluoro-2-methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-(( 1 - fluorocyclobutyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [568];

N-(4, 4-difluorocyclohexyl)-5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- 1H- benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [569];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(cis-4- methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [570];

5-(4-fluoro-2-methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-(( 1 - fluorocyclohexyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [571];

N-((4, 4-difluorocyclohexyl)methyl)-5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin -4-yl)- 1H- benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [572];

5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-( 1 - methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [573];

5-(4-fluoro-2-methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-(( 1 - methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [574];

5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-(tetrahydro-2H- pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [575];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(3-(4- methylpiperazin-l-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [576];

5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-N-(pyridin-4-yl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [577];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(2-(4- methylpiperazin- 1 -yl)pyridin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [578] ;

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(6-(4- methylpiperazin- 1 -yl)pyridin-3 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [579] ; 5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-((6-(4- methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [580] ;

6-(5 -(4-fluoro-2-methyl- 1 -( 1 -methylpiperidin-4-yl)- IH-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)quinoline [581];

5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- lH-benzo[d]imidazol-6-yl)-4-( 1 -methyl- 1H- pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine [582];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(/ra«5-4- morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [583];

1 -isopropyl -2 -methyl-6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- IH-imidazo [4,5 -b]pyridine [584] ;

6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridine

[585];

1 -isopropyl -2 -methyl-6-(2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- 1H- imidazo[4,5-b]pyridine [586];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-isopropyl-2-methyl-lH-imidazo[4,5- b]pyridine [587];

6-(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- 1 -isopropyl -2 -methyl- IH-imidazo [4,5 - b]pyridine [588];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-isopropyl-2-methyl-lH- imidazo[4,5-b]pyridine [589];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[590];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [591];

N-ethyl-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [592];

N-isopropyl-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [593];

N-isobutyl-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [594];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-neopentyl-7H-pyrrolo[2,3- d]pyrimidin-2-amine [595];

(S)-N-(sec-butyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [596]; N-(2-fluoro-2-methylpropyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [597] ;

N-(2,2-difluoropropyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [598];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [599];

(R)-5 -( 1 -isop ropyl -2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [600] ;

(S)-5 -( 1 -isopropyl-2-methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [601];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [602] ;

(S)-5 -( 1 -isop ropyl-2-methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-N-( 1 -methoxypropan -2 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [603] ;

6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridine

[604];

N-((l-fluorocyclopropyl)methyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [605] ;

(R)-N-( 1 -cyclopropylethyl)-5 -( 1 -isop ropyl -2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [606] ;

5-( 1 -isopropyl -2 -methyl- IH-imidazo [4, 5 -b]pyridin-6-yl)-N-(( 1 -methylcyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [607] ;

5 -( 1 -isopropyl -2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-N-(( 1 - (trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [608];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [609] ;

N-(3,3-difluorocyclobutyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [610];

N-((l-fluorocyclobutyl)methyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [611];

N-(4,4-difluorocyclohexyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [612];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [613]; N-(( 1 -fluorocyclohexyl)methyl)-5 -( 1 -isopropyl -2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [614];

N-((4,4-difluorocyclohexyl)methyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [615];

5 -( 1 -isopropyl -2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [616];

5-( 1 -isopropyl -2 -methyl- IH-imidazo [4, 5 -b]pyridin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [617];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [618];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-methylpiperazin-l-yl)phenyl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [619];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [620];

5-( 1 -isopropyl -2 -methyl- IH-imidazo [4, 5 -b]pyridin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin- 4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [621 ] ;

5-( 1 -isopropyl -2 -methyl- IH-imidazo [4, 5 -b]pyridin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin- 3 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [622] ;

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-((6-(4-methylpiperazin-l-yl)pyridin-

3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [623];

6-(5 -( 1 -isopropyl -2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)quinoline [624]; l-isopropyl-2-methyl-6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-lH- imidazo[4,5-b]pyridine [625];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-( /ram-4-morpholinocyclohcxyl)-7H- pyrrolo [2,3 -d]pyrimidin-4-amine [626] ;

1 -isopropyl -2 -methyl-6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- IH-imidazo [4,5 -c]pyridine [627] ;

6-(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- 1 -isopropyl -2 -methyl- IH-imidazo [4,5 - c]pyridine [628];

5 -(2,3 -dimethyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [629];

3 -(2,2-difluoroethyl)-2-methyl-5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-3H-imidazo [4,5 -b]pyridine [630]; 3-(2,2-difluoroethyl)-5-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methyl-3H-imidazo[4,5- b]pyridine [631];

3-(2,2-difluoroethyl)-2-methyl-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3H- imidazo[4,5-b]pyridine [632];

5-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-(2,2-difluoroethyl)-2-methyl-3H- imidazo[4,5-b]pyridine [633];

5-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-(2,2-difluoroethyl)-2-methyl-3H- imidazo[4,5-b]pyridine [634];

5-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-(2,2-difluoroethyl)-2-methyl-3H- imidazo[4,5-b]pyridine [635];

5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [636];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-methyl-7H-pyrrolo[2,3- d]pyrimidin-2-amine [637];

5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-ethyl-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [638];

5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-isopropyl-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [639];

5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-isobutyl-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [640];

5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-neopentyl-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [641];

(S)-N-(sec-butyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [642] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(2-fluoro-2 -methylpropyl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [643] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(2,2-difluoropropyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [644] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(2,2,2-trifluoroethyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [645] ;

(R)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(l,l,l-trifluoropropan- 2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [646] ;

(S)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(l,l,l-trifluoropropan-

2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [647] ;

589 5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(3,3,3-trifluoropropyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [648] ;

(S)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(l-methoxypropan-2- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [649];

3-(2,2-difluoroethyl)-5-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methyl-3H-imidazo[4,5- b]pyridine [650];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l- fluorocyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [651];

(R)-N-(l-cyclopropylethyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [652] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l- methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [653];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l- (trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [654];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5- b]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [655] ;

N-(3 ,3 -difluorocyclobutyl) -5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [656] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l- fluorocyclobutyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [657];

N-(4,4-difluorocyclohexyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [658] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-4-methoxycyclohexyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [659] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l- fluorocyclohexyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [660];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin- 5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [661 ] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(l-methylpiperidin-4-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [662] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l-methylpiperidin-4- yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [663];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [664] ; 5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(3-(4-methylpiperazin-l- yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [665];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [666] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(2-(4-methylpiperazin-l- yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [667];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(6-(4-methylpiperazin-l- yl)pyridin-3 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [668] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((6-(4-methylpiperazin-l- yl)pyridin-3 -yl)methyl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [669] ;

6-(5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)quinoline [670];

3-(2,2-difluoroethyl)-2-methyl-5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)-3H-imidazo [4,5 -b]pyridine [671 ] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(/ra«5-4- morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [672];

3 -isopropyl -2 -methyl-5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-3H-imidazo [4,5 -b]pyridine [673] ;

5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridine [674];

3 -isopropyl -2 -methyl-5 -(2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-3H- imidazo[4,5-b]pyridine [675];

5 -(2-cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 -isopropyl -2 -methyl-3H-imidazo [4,5 - b]pyridine [676];

5 -(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 -isopropyl -2 -methyl-3H-imidazo [4,5 - b]pyridine [677];

5-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-isopropyl-2-methyl-3H- imidazo[4,5-b]pyridine [678];

5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [679];

5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-methyl-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [680];

N-ethyl-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [681]; N-isopropyl-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [682];

N-isobutyl-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [683];

5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-neopentyl-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [684];

(S)-N-(5ec-butyl)-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [685];

N-(2-fluoro-2-methylpropyl)-5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [686] ;

N-(2,2-difluoropropyl)-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [687];

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [688];

(R)-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [689] ;

(S)-5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [690] ;

5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-(3 ,3 ,3 -trifluoropropyl) -7H- pyrrolo[2,3-d]pyrimidin-2 -amine [691];

(S)-5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(l-methoxypropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [692] ;

5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridine [693];

N-(( 1 -fluorocyclopropyl)methyl)-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [694] ;

(R)-N-(l-cyclopropylethyl)-5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [695] ;

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l-methylcyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [696] ;

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l-

(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [697];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [698] ; N-(3 ,3 -difluorocyclobutyl)-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [699] ;

N-((l-fluorocyclobutyl)methyl)-5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [700] ;

N-(4,4-difluorocyclohexyl)-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [701];

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [702] ;

N-((l-fluorocyclohexyl)methyl)-5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [703] ;

N-((4,4-difluorocyclohexyl)methyl)-5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [704] ;

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(l-methylpiperidin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [705] ;

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((l-methylpiperidin-4-yl)methyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [706] ;

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [707] ;

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(3-(4-methylpiperazin-l-yl)phenyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [708] ;

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [709];

5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin- 4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [710] ;

5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin- 3 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [711];

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((6-(4-methylpiperazin-l-yl)pyridin-

3 -yl)methy 1) -7H-pyrrolo [2 ,3 -d]pyrimidin-2-amine [712];

6-(5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)quinoline [713];

3-isopropyl-2-methyl-5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3H- imidazo[4,5-b]pyridine [714];

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-4-amine [715] ; 6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) - [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridine [716] ;

6-(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) - [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridine [717];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(tert-butyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [718];

6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[l,2,4]triazolo[l,5-a]pyridine

[719];

6-(2-cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) - [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridine [720] ;

6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[l,2,4]triazolo[l,5-a]pyridine [721];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[l,2,4]triazolo[l,5-a]pyridine [722];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-amine [723] ;

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [724];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-ethyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [725] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [726] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [727] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [728] ;

(S)-5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(sec-butyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[729];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(2,2-difluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[730];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [731];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [732];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [733];

(R)-5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [734];

(S)-5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [735];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [736];

(S)-5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-N-( 1 -methoxypropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [737];

6-(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) - [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridine [738] ; 5-([ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl)-N-(( 1 -fluorocyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [739];

(R)-5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-N-( 1 -cyclopropylethyl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [740];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(( 1 -methylcyclopropyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [741];

5-([ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [742] ;

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(2-cyclopropyl-2,2-difluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [743];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(3,3-difluorocyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [744];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(( 1 -fluorocyclobutyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [745];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(4,4-difluorocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [746];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [747];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(( 1 -fluorocyclohexyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [748];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-((4,4-difluorocyclohexyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [749];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [750];

5-([ 1 ,2,4]triazolo[ 1 ,5-a]pyridin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [751];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [752];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-l-yl)phenyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [753];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [754];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [755]; 5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [756];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [757] ;

6-(5 -([1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [758] ;

6-(4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[ 1 ,2,4]triazolo[ 1 ,5 -a]pyridine [759];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [760];

8-fluoro-6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridine [761] ;

8-fluoro-6-(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) - [ 1 ,2,4]triazolo [1,5 -a]pyridine [762] ;

8-fluoro-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[l,2,4]triazolo[l,5- a]pyridine [763];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoro-[l,2,4]triazolo[l,5-a]pyridine [764];

6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoro-[l,2,4]triazolo[l,5-a]pyridine [765];

6-(2-(cyclobutyhnethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoro-[l,2,4]triazolo[l,5-a]pyridine [766];

5 -(8 -fluoro-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [767] ;

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[768];

N-ethyl-5 -(8-fluoro- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine

[769];

5 -(8 -fluoro-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine

[770];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[771];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[772];

(S)-N-(sec-butyl)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [773];

N-(2-fluoro-2-methylpropyl)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [774];

N-(2,2-difluoropropyl)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [775]; 5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [776];

(R)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [777];

(S)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [778];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [779];

(S)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [780];

6-(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-8-fluoro- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridine [781 ] ;

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-((l-fluorocyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [782];

(R)-N-(l-cyclopropylethyl)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [783];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-((l-methylcyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [784];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [785] ;

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [786] ;

N-(3,3-difluorocyclobutyl)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [787];

5 -(8 -fluoro-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(( 1 -fluorocyclobutyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [788];

N-(4,4-difluorocyclohexyl)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [789];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [790];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-((l-fluorocyclohexyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [791];

N-((4,4-difluorocyclohexyl)methyl)-5 -(8-fluoro- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [792] ; 5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(l-methylpiperidin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [793];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [794] ;

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [795];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-l-yl)phenyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [796] ;

5 -(8 -fluoro-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [797];

5 -(8 -fluoro-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [798] ;

5 -(8 -fluoro-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [799] ;

5 -(8 -fluoro-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 - yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [800];

6-(5 -(8-fluoro- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline

[801];

8-fluoro-6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[l,2,4]triazolo[l,5- a]pyridine [802];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-4-amine [803] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-N-isopropyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [804] ;

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-

2-amine [805];

(R)-5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [806];

(S)-5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [807];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [808] ; l-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-lH-benzo[d][l,2,3]triazole [809];

6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-methyl-lH-benzo[d][l,2,3]triazole [810]; l-methyl-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-lH- benzo[d][l,2,3]triazole [811];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-methyl-lH-benzo[d][l,2,3]triazole [812];

6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazole [813] ;

6-(2-(cyclobutyhnethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-methyl-lH-benzo[d][l,2,3]triazole

[814];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [815];

N-methyl-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[816];

N-ethyl-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [817];

N-isopropyl-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[818];

N-isobutyl-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine

[819];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[820];

(S)-N-(sec-butyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [821];

N-(2-fluoro-2-methylpropyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [822];

N-(2,2-difluoropropyl)-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [823];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [824];

(R)-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-( 1 , 1 , 1 -trifluoropropan-2-yl)-7H-pyrrolo[2, 3- d]pyrimidin-2-amine [825];

(S)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [826];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [827];

(S)-N-( 1 -methoxypropan-2-yl)-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [828];

6-(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazole [829] ; N-(( 1 -fluorocyclopropyl)methyl)-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [830];

(R)-N-( 1 -cyclopropylethyl)-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-amine [831];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((l-methylcyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [832];

5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [833] ;

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [834];

N-(3,3-difluorocyclobutyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [835];

N-((l-fluorocyclobutyl)methyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [836];

N-(4,4-difluorocyclohexyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [837];

N-(c/.s-4-mcthoxycyclohcxyl )-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [838];

N-(( 1 -fluorocyclohexyl)methyl)-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [839];

N-((4,4-difluorocyclohexyl)methyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [840];

5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-amine [841];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [842];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [843];

5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(3-(4-methylpiperazin- 1 -yl)phenyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [844] ;

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [845];

5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [846] ; 5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [847] ;

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [848] ;

6-(5 -( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline [849] ; l-methyl-6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-lH- benzo[d][l,2,3]triazole [850];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [851];

1 -ethyl-6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- IH-benzo [d] [ 1 ,2,3]triazole [852] ;

1 -ethyl-6-(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- IH-benzo [d] [ 1 ,2,3 ]triazole [853] ; l-ethyl-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-lH-benzo[d][l,2,3]triazole [854];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- 1 -ethyl- lH-benzo[d] [ 1 ,2,3]triazole [855] ;

6-(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)- 1 -ethyl- IH-benzo [d] [ 1 ,2,3]triazole [856] ;

6-(2-(cyclobutyhnethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-ethyl-lH-benzo[d][l,2,3]triazole [857];

5 -( 1 -ethyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [858] ;

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [859];

N-ethyl-5-( 1 -ethyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [860] ;

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[861];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[862];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[863];

(S)-N-(sec-butyl)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [864];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [865];

N-(2,2-difluoropropyl)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [866];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [867]; (R)-5 -( 1 -ethyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [868];

(S)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [869];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-

2-amine [870];

(S)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [871];

6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-l-ethyl-lH-benzo[d][l,2,3]triazole [872];

5-( 1 -ethyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(( 1 -fluorocyclopropyl)methyl)-7H-pyrrolo[2,3 - d]pyrimidin-2-amine [873];

(R)-N-(l-cyclopropylethyl)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [874];

5-( 1 -ethyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(( 1 -methylcyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [875];

5-( 1 -ethyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [876] ;

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [877];

N-(3,3-difluorocyclobutyl)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [878];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((l-fluorocyclobutyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [879];

N-(4,4-difluorocyclohexyl)-5-( 1 -ethyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [880];

5-( 1 -ethyl- lH-benzo[d] [ 1 ,2,3 |triazol-6-yl)-N-(c/.s-4-mcthoxycyclohcxyl )-7H-pyrrolo[ 2.3 - d]pyrimidin-2-amine [881];

5-( 1 -ethyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(( 1 -fluorocyclohexyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [882];

N-((4,4-difluorocyclohexyl)methyl)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [883];

5 -( 1 -ethyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [884]; 5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [885];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [886];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(3-(4-methylpiperazin-l-yl)phenyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [887];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [888];

5 -( 1 -ethyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [889] ;

5 -( 1 -ethyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [890] ;

5-( 1 -ethyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)methyl)-

7H-pyrrolo[2,3-d]pyrimidin-2-amine [891];

6-(5 -( 1 -ethyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [892] ;

1 -ethyl-6-(4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- 1H- benzo[d][l,2,3]triazole [893];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [894];

N-(2-fluoro-2-methylpropyl)-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [895];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [896] ;

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidine [897] ;

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo[2,3 -d]pyrimidine [898] ;

2-cyclopropyl-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d] pyrimidine [899] ;

2-cyclobutyl-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [900] ;

2-(cyclobutylmethyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [901];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [902] ;

5-(imidazo[l,2-b]pyridazin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [903];

N-ethyl-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [904] ;

5-(imidazo[l,2-b]pyridazin-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [905];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [906] ;

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-neopentyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [907] ;

(S)-N-(sec-butyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [908]; N-(2-fluoro-2-methylpropyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [909];

N-(2,2-difluoropropyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[910];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[911];

(R)-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [912];

(S)-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-

2-amine [913];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [914];

(S)-5-(imidazo[l,2-b]pyridazin-6-yl)-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [915];

2-ethoxy-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [916];

N-(( 1 -fluorocyclopropyl)methyl)-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [917];

(R)-N-(l-cyclopropylethyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [918];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -methylcyclopropyl)methyl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [919];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [920];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [921];

N-(3 ,3 -difluorocyclobutyl) -5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [922];

N-((l-fluorocyclobutyl)methyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [923];

N-(4,4-difluorocyclohexyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [924];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [925]; N-(( 1 -fluorocyclohexyl)methyl)-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [926];

N-((4,4-difluorocyclohexyl)methyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [927];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [928];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [929];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [930];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [931];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [932];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [933];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [934];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [935] ;

6-(5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [936] ;

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo [2,3 -d]pyrimidine [937];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [938];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [939] ;

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidine [940] ;

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidine [941];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-2-cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidine [942] ;

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-2-cyclobutyl-7H-pyrrolo[2,3 -d]pyrimidine [943] ;

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-2-(cyclobutylmethyl)-7H-pyrrolo [2,3 -d]pyrimidine [944];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [945] ;

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-methyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [946] ; 5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-ethyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [947] ;

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-isopropyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [948];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [949] ;

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-neopentyl-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine

[950];

(S)-N-(sec-butyl)-5-(3-chloroimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[951];

5-(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [952];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [953];

5-(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [954];

(R)-5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [955];

(S)-5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [956];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [957];

(S)-5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1 -methoxypropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [958];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidine [959] ;

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -fluorocyclopropyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [960];

(R)-5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1 -cyclopropylethyl) -7H-pyrrolo [2,3 - d]pyrimidin-2-amine [961];

5-(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -methylcyclopropyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [962];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [963] ;

5-(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-(2-cyclopropyl-2,2-difluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [964]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(3 ,3 -difluorocyclobutyl) -7H-pyrrolo [2,3 - d]pyrimidin-2-amine [965]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -fluorocyclobutyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [966]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(4,4-difluorocyclohexyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [967]; -(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [968]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -fluorocyclohexyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [969]; -(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-((4,4-difluorocyclohexyl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [970]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [971]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [972]; -(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [973]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [974]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [975]; -(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [976] ; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [977]; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [978] ; -(5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [979] ; -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo [2,3 - d]pyrimidine [980]; -(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [981]; -(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [982]; 2-isobutyl-5 -(2-methylimidazo[ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [983] ;

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidine [984];

2-cyclopropyl-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [985] ; 2-cyclobutyl-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [986] ; 2-(cyclobutylmethyl)-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [987];

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [988];

N-methyl-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [989] ; N-ethyl-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [990];

N-isopropyl-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [991];

N-isobutyl-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [992] ; 5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[993];

(S)-N-(sec-butyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[994];

N-(2-fluoro-2-methylpropyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [995];

N-(2,2-difluoropropyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [996];

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [997];

(R)-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [998];

(S)-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [999]; and

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [1000]; or a pharmaceutically acceptable salt thereof.

25. The compound according to any one of claims 1-22, wherein the compound of Formula I is selected from the group consisting of: (S)-N-(l-methoxypropan-2-yl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1001];

2 -ethoxy-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1002] ; N-(( 1 -fluorocyclopropyl)methyl)-5-(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-amine [1003];

(R)-N-( 1 -cyclopropylethyl)-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1004];

N-((l-methylcyclopropyl)methyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1005];

5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1006];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1007];

N-(3,3-difluorocyclobutyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1008];

N-(( 1 -fluorocyclobutyl)methyl)-5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1009];

N-(4,4-difluorocyclohexyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1010];

N-(cis-4-methoxycyclohexyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1011];

N-((l-fluorocyclohexyl)methyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1012];

N-((4,4-difluorocyclohexyl)methyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1013];

5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-amine [1014];

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-N-((l-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1015];

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1016];

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-N-(3-(4-methylpiperazin-l-yl)phenyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1017];

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1018];

5 -(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1019]; 5-(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1020];

5-(2-methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)methyl)-

7H-pyrrolo[2,3-d]pyrimidin-2-amine [1021];

6-(5 -(2-methylimidazo[ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)quinoline [1022] ;

4-(l-methyl-lH-pyrazol-4-yl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [1023];

5 -(2 -methylimidazo [ 1 ,2-b] pyridazin-6-y 1) -N -(/ram-4-mo rphol i nocycl ohexy 1 ) -7H-py rrolo [2,3- d]pyrimidin-4-amine [1024];

5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1025] ;

2-isobutyl-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1026] ;

5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidine

[1027];

2-cyclopropyl-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [1028];

2-cyclobutyl-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1029] ;

2-(cyclobutylmethyl)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1030];

5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1031];

N-methyl-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1032] ;

N-ethyl-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1033];

N-isopropyl-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1034];

N-isobutyl-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine

[1035];

5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1036];

(S)-N-(sec-butyl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[1037];

N-(2-fluoro-2-methylpropyl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1038];

N-(2,2-difluoropropyl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1039];

5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1040]; (R)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1041];

(S)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1042];

5 -(3 -methylimidazo [ 1 ,2-b] pyridazin-6-y 1) -N-(3 , 3 , 3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [1043];

(S)-N-(l-methoxypropan-2-yl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1044];

2 -ethoxy-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1045] ;

N-(( 1 -fluorocyclopropyl)methyl)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1046];

(R)-N-( 1 -cyclopropylethyl)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1047];

N-(( 1 -methylcyclopropyl)methyl)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1048];

5-(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1049];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1050];

N-(3,3-difluorocyclobutyl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1051];

N-(( 1 -fluorocyclobutyl)methyl)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1052];

N-(4,4-difluorocyclohexyl)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1053];

N-(cri-4-methoxycyclohexyl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1054];

N-(( 1 -fluorocyclohexyl)methyl)-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1055];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1056];

5-(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-amine [1057]; -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1058]; -(3-methylimidazo[l,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1059]; -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(3-(4-methylpiperazin- 1 -yl)phenyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1060]; -(3-methylimidazo[l,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1061]; -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1062]; -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1063]; -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)methyl)-

7H-pyrrolo[2,3-d]pyrimidin-2-amine [1064]; -(5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline [1065]; -(l-methyl-lH-pyrazol-4-yl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidine [1066]; -(3-methylimidazo[l,2-b]pyridazin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine [1067]; -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1068] ; -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidine [1069]; -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 - d]pyrimidine [1070]; -cyclopropyl-5 -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1071]; -cyclobutyl-5 -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidine [1072]; -(cyclobutylmethyl)-5 -(3 -(difluoromethyl)imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidine [1073]; -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1074] ; -(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1075]; 5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1076];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1077];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1078];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1079];

(S)-N-(sec-butyl)-5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1080];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1081];

5 -(3 -(difluoromethyl)imidazo [ 1 ,2-b]pyridazin-6-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1082];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1083];

(R)-5 -(3 -(difluoromethyl)imidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan -2 -yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1084];

(S)-5 -(3 -(difluoromethyl)imidazo [ 1 ,2-b]pyridazin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1085];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1086];

(S)-5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(l-methoxypropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1087];

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidine [1088];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -fluorocyclopropyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1089];

(R)-N-(l-cyclopropylethyl)-5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1090];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -methylcyclopropyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1091];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [1092]; N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1093];

N-(3,3-difluorocyclobutyl)-5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1094];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -fluorocyclobutyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1095];

N-(4,4-difluorocyclohexyl)-5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1096];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1097];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -fluorocyclohexyl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1098];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1099];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1100];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1101];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1102] ;

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-(3 -(4-methylpiperazin- 1 -yl)phenyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1103] ;

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1104];

5-(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1105] ;

5 -(3 -(difluoromethyl)imidazo [ 1 ,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1106] ;

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 - yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1107];

6-(5 -(3 -(difluoromethyl)imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)quinoline [1108];

5 -(3 -(difluoromethyl)imidazo[ 1 ,2-b]pyridazin-6-yl)-4-( 1 -methyl- lH-pyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidine [1109]; 5 -(3 -(difluoromethyl)imidazo [ 1 ,2-b ] py ridazi n-6-yl )-N-(/ram-4-morphol i nocyclohexyl )-7H- pyrrolo [2,3 -d]pyrimidin-4-amine [1110];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidine [1111];

2-isobutyl-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1112];

2-isobutyl-4-methoxy-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1113];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidine [1114];

2-cyclopropyl-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1115];

2-cyclobutyl-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidine [1116];

2-(cyclobutylmethyl)-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1117];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-amine [1118];

N-methyl-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1119];

N-ethyl-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1120];

N-isopropyl-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1121];

N-isobutyl-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [1122] ;

N-neopentyl-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1123];

(S)-N-(sec-butyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1124];

N-(2-fluoro-2-methylpropyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1125];

N-(2,2-difluoropropyl)-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1126];

5-(pyrazolo[l,5-a]pyridin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1127];

(R)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [1128];

(S)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1129];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [1130];

(S)-N-(l-methoxypropan-2-yl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1131];

2 -ethoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1132] ;

N-(( 1 -fluorocyclopropyl)methyl)-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1133]; (R)-N-( 1 -cyclopropylethyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1134];

N-(( 1 -methy Icy clopropyl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1135];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1136];

N-(2 -cyclopropyl -2, 2-difluoroethyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [1137];

N-(3,3-difluorocyclobutyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1138];

N-(( 1 -fluorocyclobutyl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1139];

N-(cis-3 -methoxy cyclobutyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1140];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-(2 -oxaspiro [3.3 ]heptan-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1141];

N-(4,4-difluorocyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1142];

N-(cis-4-methoxycyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1143];

N-((l-fluorocyclohexyl)methyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1144];

N-((4,4-difluorocyclohexyl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [1145];

N-( 1 -methylpiperidin-4-yl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1146];

N-(( 1 -methy lpiperidin-4-yl)methyl)-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [1147];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1148];

N-(3-(4-methylpiperazin-l-yl)phenyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1149];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [1150] ; N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1151];

N-(6 -(4-methylpiperazin- 1 -yl)pyridin-3 -y 1) -5 -(pyrazolo [1,5 -a]py ridin-5 -y 1) -7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1152];

N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1153] ;

6-(5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [1154] ;

4-( 1 -methyl- lH-pyrazol-4-yl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1155];

N-(/ra«5-4-morpholinocyclohexyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 4-amine [1156];

N-(2-fluoro-2-methylpropyl)-5 -(3 -fluoropyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1157];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1158];

2-isobutyl-5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidine [1159];

5 -(3 -( 1 -methyl- 1 H-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -y 1) -2-(3 , 3 , 3 -trifluoropropyl) -7H- pyrrolo[2,3-d]pyrimidine [1160];

2-cyclopropyl-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidine [1161];

2-cyclobutyl-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidine [1162];

2-(cyclobutylmethyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidine [1163];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1164];

N-methyl-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1165];

N-ethyl-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1166];

N-isopropyl-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1167]; N-isobutyl-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1168];

5 -(3 -( 1 -methyl- 1 H-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -y 1) -N -neopentyl-7H-pyrrolo [2,3- d]pyrimidin-2-amine [1169];

(S)-N-(sec-butyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1170];

N-(2-fluoro-2-methylpropyl)-5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1171];

N-(2,2-difluoropropyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1172];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(2,2,2-trifluoroethyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1173];

(R)-5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-N-(l,l,l-trifluoropropan-2-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1174];

(S)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1175];

5 -(3 -( 1 -methyl- 1 H-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -y 1) -N-(3 , 3 , 3 -trifluoropropyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1176];

(S)-N-(l-methoxypropan-2-yl)-5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1177];

2 -ethoxy-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5-yl)-7H-pyrrolo [2,3 - d]pyrimidine [1178];

N-(( 1 -fluorocyclopropyl)methyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1179];

(R)-N-( 1 -cyclopropylethyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo[ 1 ,5 -a]pyridin-5 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1180] ;

5 -(3 -( 1 -methyl- 1 H-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -y 1) -N-(( 1 -methylcyclopropyl)methyl) - 7H-pyrrolo[2,3-d]pyrimidin-2-amine [1181];

5 -(3 -( 1 -methyl- 1 H-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -y 1) -N-(( 1 - (trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1182];

N-(2 -cyclopropyl -2, 2-difluoroethyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 - yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1183] ;

N-(3 , 3 -difluorocyclobutyl) -5 -(3 -( 1 -methyl- 1 H-pyrazol-4-yl)pyrazolo [ 1 , 5 -a]py ridin-5 -y 1) -7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1184] ; N-(( 1 -fluorocyclobutyl)methyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1185] ;

N-(4,4-difluorocyclohexyl)-5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1186] ;

N-(cis-4-methoxycyclohexyl)-5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1187];

N-(( 1 -fluorocyclohexyl)methyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1188] ;

N-((4,4-difluorocyclohexyl)methyl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 - yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1189] ;

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-( 1 -methylpiperidin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1190] ;

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(( 1 -methylpiperidin-4- yl)methy 1) -7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [1191];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1192] ;

5 -(3 -( 1 -methyl- 1 H-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -y 1) -N-(3 -(4-methy Ipiperazin- 1 - yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1193];

5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1194];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(2-(4-methy Ipiperazin- 1 - yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1195];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(6-(4-methy Ipiperazin- 1 - yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1196];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-((6-(4-methylpiperazin- 1 - yl)pyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1197];

6-(5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)quinoline [1198];

4-( 1 -methyl- lH-pyrazol-4-yl)-5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [1,5 -a]pyridin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidine [1199];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -y 1 )-N-(/ram-4-morphol i nocyclohexyl )- 7H-pyrrolo[2,3-d]pyrimidin-4-amine [1200];

(5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)(piperidin- 1 -yl)methanone [1201]; (5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)(piperidin- 1 - yl)methanone [1202]; piperidin- 1 -yl(5 -(2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)methanone [1203];

(5 -(2-cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)(piperidin- 1 - yl)methanone [1204];

(5 -(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)(piperidin- 1 - yl)methanone [1205];

(5 -(2-(cyclobutylmethyl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridin-3 - yl)(piperidin- 1 -yl)methanone [1206] ;

(5 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)(piperidin- 1 - yl)methanone [1207];

(5 -(2-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3-yl)(piperidin- 1 - yl)methanone [1208];

(5 -(2-(ethylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)(piperidin- 1 - yl)methanone [1209];

(5 -(2-(isopropylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridin-3 -yl)(piperidin- l-yl)methanone [1210];

(5 -(2-(isobutylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridin-3 -yl)(piperidin- 1 - yl)methanone [1211];

(5 -(2-(neopentylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)(piperidin- l-yl)methanone [1212];

(S)-(5 -(2-(.st'c-butylam i no)-7H-py rrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 - yl)(piperidin- 1 -yl)methanone [1213] ;

(5 -(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridin- 3 -y I [(piperidin- 1 -yl)methanone [1214] ;

(5 -(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3- yl)(piperidin- 1 -yl)methanone [1215] ; piperidin- 1 -yl(5 -(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)methanone [1216];

(R)-piperidin- 1 -yl(5 -(2-(( 1,1,1 -trifluoropropan -2 -yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridin-3 -yl)methanone [1217];

(S)-piperidin- 1 -yl(5 -(2-(( 1,1,1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridin-3 -yl)methanone [1218]; piperidin- 1 -y 1 (5 -(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)methanone [1219];

(S)-(5 -(2-(( 1 -methoxypropan -2 -yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1220];

(5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)(piperidin- 1 - yl)methanone [1221];

(5 -(2-((( 1 -fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1222];

(R)-(5 -(2-(( 1 -cyclopropylethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin- 3 -yl)(piperidin- 1 -yl)methanone [1223] ;

(5 -(2-((( 1 -methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1224]; piperidin- 1 -yl(5 -(2-((( 1 -(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 -yl)methanone [1225] ;

(5 -(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1226];

(5 -(2-((3 ,3 -difluorocyclobutyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridin-3 - yl)(piperidin- 1 -yl)methanone [1227] ;

(5 -(2-((( 1 -fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1228];

(5 -(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin- 3 -yl)(piperidin- 1 -yl)methanone [1229] ;

(5 -(2-((c/.s-4-mcthoxycyclohcxyl )am i no)-7H-py rrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1230];

(5 -(2-((( 1 -fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1231];

(5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1232];

(5 -(2-(( 1 -methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin- 3 -yl)(piperidin- 1 -yl)methanone [1233] ;

(5 -(2-((( 1 -methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1234]; piperidin-l-yl(5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo[ 1 ,5-a]pyridin-3-yl)methanone [1235] ; (5 -(2-((3 -(4-methylpiperazin- 1 -yl)phenyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1236]; piperidin- 1 -yl(5 -(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridin- 3-yl)methanone [1237];

(5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo[ 1 ,5-a]pyridin-3-yl)(piperidin- 1 -yl)methanone [1238] ;

(5 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo[ 1 ,5-a]pyridin-3-yl)(piperidin- 1 -yl)methanone [1239] ;

(5 -(2-(((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo[ 1 ,5-a]pyridin-3-yl)(piperidin- 1 -yl)methanone [1240] ; piperidin- 1 -yl(5 -(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridin-3 - yl)methanone [1241];

(5 -(4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3 - yl)(piperidin- 1 -yl)methanone [1242] ;

(5 -(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3-yl)(piperidin-l-yl)methanone [1243];

(5 -(4-((cyclopropylmethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridin-3 - yl)(4-methylpiperazin- 1 -yl)methanone [1244] ;

5 -(2-cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N,N-dimethylpyrazolo [ 1 ,5 -a]pyridine-3 - carboxamide [1245];

N-(2,2-difluoroethyl)-5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 - carboxamide [1246];

N-(2,2-difluoroethyl)-5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 - carboxamide [1247];

N-(2,2-difluoroethyl)-5 -(2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1248];

5-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1249];

5-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)pyrazolo[l,5-a]pyridine- 3-carboxamide [1250];

5-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1251];

5 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(2,2-difluoroethyl)pyrazolo [1,5 -a]pyridine-3 - carboxamide [1252]; N-(2,2-difluoroethyl)-5-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1253];

N-(2,2-difluoroethyl)-5 -(2-(ethylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1254];

N-(2,2-difluoroethyl)-5 -(2-(isopropylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1255];

N-(2,2-difluoroethyl)-5 -(2-(isobutylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1256];

N-(2,2-difluoroethyl)-5 -(2-(neopentylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1257];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1258];

N-(2,2-difluoroethyl)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1259];

N-(2,2-difluoroethyl)-5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1260];

N-(2,2-difluoroethyl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1261];

(R)-N-(2,2-difluoroethyl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1262];

(S)-N-(2,2-difluoroethyl)-5 -(2-(( 1,1,1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-

5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1263];

N-(2,2-difluoroethyl)-5 -(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1264];

(S)-N-(2,2-difluoroethyl)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1265];

N-(2,2-difluoroethyl)-5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 - carboxamide [1266];

N-(2,2-difluoroethyl)-5-(2-(((l-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1267];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1268] ;

N-(2,2-difluoroethyl)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1269]; N-(2,2-difluoroethyl)-5-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1270] ;

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1271] ;

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1272] ;

N-(2,2-difluoroethyl)-5-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1273] ;

5 -(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(2,2- difluoroethyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1274] ;

N-(2,2-difluoroethyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1275] ;

N-(2,2-difluoroethyl)-5-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1276] ;

5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2- difluoroethyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1277] ;

N-(2,2-difluoroethyl)-5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1278] ;

N-(2,2-difluoroethyl)-5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1279] ;

N-(2,2-difluoroethyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1280];

N-(2,2-difluoroethyl)-5-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1281];

N-(2,2-difluoroethyl)-5 -(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1282];

N-(2,2-difluoroethyl)-5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1283] ;

N-(2,2-difluoroethyl)-5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1284] ;

N-(2,2-difluoroethyl)-5-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1285] ;

N-(2,2-difluoroethyl)-5 -(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1286]; N-(2,2-difluoroethyl)-5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1287];

N-(2.2-difliiorocthyl)-5-(4-((/raw.s-4-morpholinocyclohcxyl)amino)-7H-pyrrolo|2.3-d|pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1288];

N-(2-fluoro-2-methylpropyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5-a]pyridine-3- carboxamide [1289];

N-(2-fluoro-2-methylpropyl)-5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1290];

N-(2-fluoro-2-methylpropyl)-5 -(2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1291];

5-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1292];

5-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1293];

5-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1294];

5 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1295];

N-(2-fluoro-2-methylpropyl)-5-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1296];

5-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1297];

N-(2-fluoro-2-methylpropyl)-5-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1298];

N-(2-fluoro-2-methylpropyl)-5-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1299];

N-(2-fluoro-2-methylpropyl)-5-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1300] ;

(S)-5-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1301];

N-(2-fluoro-2-methylpropyl)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1302] ;

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1303]; N-(2-fluoro-2-methylpropyl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1304];

(R)-N-(2-fluoro-2-methylpropyl)-5 -(2-(( 1,1,1 -trifluoropropan -2 -yl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1305] ;

(S)-N-(2-fluoro-2-methylpropyl)-5 -(2-(( 1,1,1 -trifluoropropan -2 -yl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1306] ;

N-(2-fluoro-2-methylpropyl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1307];

(S)-N-(2-fluoro-2-methylpropyl)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1308] ;

5-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1309];

N-(2-fluoro-2-methylpropyl)-5-(2-(((l-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1310];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1311];

N-(2-fluoro-2-methylpropyl)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1312];

N-(2-fluoro-2-methylpropyl)-5-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1313] ;

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1314];

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1315];

N-(2-fluoro-2-methylpropyl)-5-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1316];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1317];

N-(2-fluoro-2-methylpropyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1318];

N-(2-fluoro-2-methylpropyl)-5-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1319];

5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1320]; N-(2-fluoro-2-methylpropyl)-5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1321];

N-(2-fluoro-2-methylpropyl)-5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1322] ;

N-(2-fluoro-2-methylpropyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1323] ;

N-(2-fluoro-2-methylpropyl)-5-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1324] ;

N-(2-fluoro-2-methylpropyl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1325];

N-(2-fluoro-2-methylpropyl)-5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1326] ;

N-(2-fluoro-2-methylpropyl)-5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1327] ;

N-(2-fluoro-2-methylpropyl)-5-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1328] ;

N-(2-fluoro-2-methylpropyl)-5-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1329];

N-(2-fluoro-2-methylpropyl)-5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1330];

N-(2-fluoro-2-methylpropyl)-5-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1331];

(R)-5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)pyrazolo [ 1 ,5 -a]pyridine- 3-carboxamide [1332];

(R)-5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 , 1 , 1 -trifluoropropan-2-yl)pyrazolo [ 1 ,5 - a]pyridine -3 -carboxamide [1333];

(R)-N-(l,l,l-trifluoropropan-2-yl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1334];

(R)-5-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1335];

(R)-5 -(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1336];

(R)-5-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1337]; (R)-5 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1338];

(R)-5-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1339];

(R)-5-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1340];

(R)-5 -(2-(isopropylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1341];

(R)-5-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1342];

(R)-5-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan-2- yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1343] ;

5-(2-(((S)-sec-butyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((R)-l,l,l-trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1344];

(R)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1345] ;

(R)-5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan- 2-yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1346] ;

(R)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1347] ;

N-((R)- 1 ,1,1 -trifluoropropan-2-yl)-5 -(2-(((R)- 1,1,1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1348] ;

N-((R)- 1 ,1,1 -trifluoropropan-2-yl)-5 -(2-(((S)- 1 , 1 , 1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1349] ;

(R)-N-(l,l,l-trifluoropropan-2-yl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1350] ;

5-(2-(((S)-l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((R)-l,l,l- trifluoropropan-2-yl)pyrazolo[ 1 ,5 -a]pyridine-3 -carboxamide [1351] ;

(R)-5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1352];

(R)-5 -(2-((( 1 -fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1353] ;

5-(2-(((R)-l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((R)-l,l,l- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1354] ; (R)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1355] ;

(R)-5-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- (1,1,1 -trifluoropropan -2 -yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1356] ;

(R)-5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1357] ;

(R)-5 -(2-((3 ,3 -difluorocyclobutyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1358] ;

(R)-5-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1359] ;

(R)-5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1360] ;

5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((R)-l,l,l- trifluoropropan-2-yl)pyrazolo[ 1 ,5 -a]pyridine-3 -carboxamide [1361] ;

(R)-5 -(2-((( 1 -fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1362] ;

(R)-5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1363] ;

(R)-5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1364] ;

(R)-5 -(2-((( 1 -methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1365] ;

(R)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l,l,l- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1366] ;

(R)-5 -(2-((3 -(4-methylpiperazin- 1 -yl)phenyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1367] ;

(R)-5 -(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1368];

(R)-5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- (1,1,1 -trifluoropropan -2 -yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1369] ;

(R)-5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- (1,1,1 -trifluoropropan -2 -yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1370] ;

(R)-5 -(2-(((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)-N-( 1,1,1 -trifluoropropan-2-yl)pyrazolo[ 1 ,5-a]pyridine-3-carboxamide [1371] ; (R)-5 -(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2- yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1372] ;

(R)-5 -(4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-

2-yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1373] ;

5-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((R)- 1,1,1- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1374] ;

N-(3,3-difluorocyclobutyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5-a]pyridine-3- carboxamide [1375];

N-(3 ,3 -difluorocyclobutyl) -5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1376];

N-(3 ,3 -difluorocyclobutyl)-5 -(2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1377];

5 -(2 -cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N-(3 , 3 -difluorocyclobutyl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1378];

5 -(2 -cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N-(3 , 3 -difluorocyclobutyl)-N - methylpyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1379] ;

5-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1380];

5 -(2 -(cy clobutylmethyl)-7H-py rrolo [2,3 -d]pyrimidin-5 -y 1) -N-(3 , 3 - difluorocyclobutyl)pyrazolo[ 1 ,5 -a]pyridine-3 -carboxamide [1381] ;

5 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(3 ,3 -difluorocyclobutyl)pyrazolo [1,5 -a]pyridine-

3-carboxamide [1382];

N-(3,3-difluorocyclobutyl)-5-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1383];

N-(3 , 3 -difluorocyclobutyl) -5 -(2-(ethylamino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1384];

N-(3 ,3 -difluorocyclobutyl) -5 -(2-(isopropylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1385];

N-(3,3-difluorocyclobutyl)-5-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1386];

N-(3 , 3 -difluorocyclobutyl) -5 -(2-(neopentylamino) -7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1387];

(S)-5 -(2-(.scc-buty lam i no)-7H-py rrolo [2,3 -d]pyrimidin-5 -yl)-N-(3 ,3 - difluorocyclobutyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1388] ; N-(3,3-difluorocyclobutyl)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1389];

N-(3 ,3 -difluorocyclobutyl) -5 -(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1390];

N-(3,3-difluorocyclobutyl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1391];

(R)-N-(3,3-difluorocyclobutyl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1392] ;

(S)-N-(3,3-difluorocyclobutyl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1393] ;

N-(3 , 3 -difluorocyclobutyl) -5-(2-((3, 3 ,3 -trifluoropropyl)amino) -7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1394];

(S)-N-(3,3-difluorocyclobutyl)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1395] ;

N-(3 , 3 -difluorocyclobutyl) -5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1396];

N-(3 ,3 -difluorocyclobutyl) -5 -(2-((( 1 -fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1397] ;

(R)-5 -(2-(( 1 -cyclopropylethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(3 ,3 - difluorocyclobutyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1398] ;

N-(3,3-difluorocyclobutyl)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1399] ;

N-(3 , 3 -difluorocyclobutyl) -5-(2-(((l -(trifluoromethyl)cyclopropyl)methy l)amino) -7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1400] ;

5 -(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(3 ,3 - difluorocyclobutyl)pyrazolo[ 1 ,5 -a]pyridine-3 -carboxamide [1401] ;

N-(3 , 3 -difluorocyclobutyl) -5-(2-((3,3 -difluorocy clobutyl)amino) -7H-py rrolo [2, 3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1402];

N-(3 , 3 -difluorocyclobutyl) -5-(2-(((l -fluorocyclobutyl)methy l)amino) -7H-pyrrolo [2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1403] ;

N-(3,3-difluorocyclobutyl)-5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1404];

N-(3,3-difluorocyclobutyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1405]; N-(3 , 3 -difluorocyclobutyl) -5 -(2-((( 1 -fluorocyclohexyl)methyl)amino) -7H-pyrrolo [2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1406] ;

N-(3,3-difluorocyclobutyl)-5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1407] ;

N-(3 ,3 -difluorocyclobutyl) -5 -(2-(( 1 -methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1408];

N-(3,3-difluorocyclobutyl)-5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1409] ;

N-(3,3-difluorocyclobutyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1410];

N-(3,3-difluorocyclobutyl)-5-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1411];

N-(3 ,3 -difluorocyclobutyl) -5 -(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1412];

N-(3,3-difluorocyclobutyl)-5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1413];

N-(3,3-difluorocyclobutyl)-5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1414];

N-(3,3-difluorocyclobutyl)-5-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1415] ;

N-(3 ,3 -difluorocyclobutyl) -5 -(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1416];

N-(3,3-difluorocyclobutyl)-5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1417];

N-(3,3-difluorocyclobutyl)-5-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1418];

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(7H-pyrrolo[2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine- 3-carboxamide [1419];

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1420];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1421];

5 -(2 -cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N-((3 , 3 - difluorocyclobutyl)methyl)pyrazolo[l,5-a]pyridine-3-carboxamide [1422];

632 5 -(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-((3 ,3 - difluorocyclobutyl)methyl)pyrazolo[l,5-a]pyridine-3-carboxamide [1423];

5 -(2 -(cy clobutylmethyl)-7H-py rrolo [2,3 -d]pyrimidin-5 -y 1) -N-((3 ,3 - difluorocyclobutyl)methyl)pyrazolo[l,5-a]pyridine-3-carboxamide [1424];

5 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-((3 ,3 -difluorocyclobutyl)methyl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1425];

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1426];

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-(ethylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1427];

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-(isopropylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1428];

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-(isobutylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1429];

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-(neopentylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1430];

(S)-5 -(2-(.scc-buty lam i no)-7H-py rrolo [2,3 -d]pyrimidin-5 -yl)-N-((3 ,3 - difluorocyclobutyl)methyl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1431];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1432] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1433] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1434] ;

(R)-N-((3,3-difluorocyclobutyl)methyl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1435] ;

(S)-N-((3,3-difluorocyclobutyl)methyl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1436] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1437] ;

(S)-N-((3,3-difluorocyclobutyl)methyl)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1438] ;

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1439]; N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((l-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1440] ;

(R)-5 -(2-(( 1 -cyclopropylethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-((3 ,3 - difluorocyclobutyl)methyl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1441];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1442] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1443] ;

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((3,3- difluorocyclobutyl)methyl)pyrazolo[l,5-a]pyridine-3-carboxamide [1444];

5 -(2 -((3 ,3 -difluorocy clobutyl)amino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N-((3 ,3 - difluorocyclobutyl)methyl)pyrazolo[l,5-a]pyridine-3-carboxamide [1445];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1446] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1447] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1448] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1449] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1450] ;

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-(( 1 -methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1451];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1452] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1453] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1454] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1455];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1456] ; N-((3,3-difluorocyclobutyl)methyl)-5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1457] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3- yl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1458];

N-((3 ,3 -difluorocyclobutyl)methyl)-5 -(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1459];

N-((3,3-difluorocyclobutyl)methyl)-5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1460] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1461 ] ;

N-(/raw.s'-4-mcthoxycyclohcxyl )-5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridine-3 - carboxamide [1462];

5-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4-methoxycyclohexyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1463];

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1464];

5-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4-methoxycyclohexyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1465];

5-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4-methoxycyclohexyl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1466];

5-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1467] ;

5 -(2-amino-7H-pyrrolo 12.3 -d |py rim idm-5 -yl )-N-(/ram-4-mcthoxycyclohcxyl )py razolo [1,5- a]pyridine -3 -carboxamide [1468];

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1469];

5-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1470] ;

5-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1471] ;

5-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1472] ; N-(/ra«5-4-methoxycyclohexyl)-5-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1473] ;

5-(2-(((S)-5ec-butyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1474] ;

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1475] ;

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1476] ;

N-(/raw.s-4-mcthoxycyclohcxyl)-5-(2-((2.2.2-trifliiorocthyl)amino)-7H-pyrrolo|2.3-d|pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1477];

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(((R)-l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1478] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(((S)-l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1479] ;

N-(/raw.s'-4-mcthoxycyclohcxyl )-5 -(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1480];

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(((S)-l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1481];

5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(/ram-4-mcthoxycyclohcxyl)pyrazolo [ 1 ,5 - a]pyridine -3 -carboxamide [1482];

5-(2-(((l-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1483] ;

5-(2-(((R)-l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1484] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1485] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [I486] ;

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxy cyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1487] ;

5-(2-((3,3 -difluorocy clobutyl)amino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N -(trans -4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1488] ;

5-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1489] ; 5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxy cyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1490] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1491];

5-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1492] ;

5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(/ra«5-4- methoxy cyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1493] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1494] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1495] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1496] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1497] ;

N-(/ra«5-4-methoxycyclohexyl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1498];

N-(/ra«5-4-methoxycyclohexyl)-5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1499] ; and

N-(/ra«5-4-methoxycyclohexyl)-5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H- pyrrolo[2,3-d]pyrimidin-5-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1500]; or a pharmaceutically acceptable salt thereof.

26. The compound according to any one of claims 1-22, wherein the compound of Formula I is selected from the group consisting of: N-(/ra«5-4-methoxycyclohexyl)-5-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)- 7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1501 ] ;

N-(/ram-4-mcthoxycyclohcxyl)-5-(2-(qiiinolin-6-yl)-7H-pyrrolo|2.3-d|pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1502];

N-(/ram-4-mcthoxycyclohcxyl)-5-(4-( l-mcthyl-l H-pyrazol-4-yl)-7H-pyrrolo|2.3-d|pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1503];

N-(/raM5-4-methoxycyclohexyl)-5-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1504] ;

637 N-( 1 -methylpiperidin-4-yl)-5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 - carboxamide [1505];

5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 -methylpiperidin-4-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1506];

N-( 1 -methylpiperidin-4-yl)-5 -(2-(3 ,3 ,3 -trifluoropropyl) -7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1507];

5 -(2-cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 -methylpiperidin-4-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1508];

5 -(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 -methylpiperidin-4-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1509];

5-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1510];

5 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 -methylpiperidin-4-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1511];

5-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1512];

5 -(2 -(ethylamino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 -methylpiperidin-4-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1513];

5-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1514];

5 -(2-(isobutylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 -methylpiperidin-4-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1515];

N-(l-methylpiperidin-4-yl)-5-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1516];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1517];

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin- 4-yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1518];

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1519];

N-(l-methylpiperidin-4-yl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1520];

(R)-N-( 1 -methylpiperidin-4-yl)-5 -(2-(( 1 , 1 , 1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1521]; (S)-N-( 1 -methylpiperidin-4-yl)-5 -(2-(( 1,1,1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1522] ;

N-( 1 -methylpiperidin-4-yl)-5 -(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1523];

(S)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l- methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1524];

5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 -methylpiperidin-4-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1525];

5 -(2-((( 1 -fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-( 1 - methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1526];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1527];

5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l- methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1528];

N-(l-methylpiperidin-4-yl)-5-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1529] ;

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l- methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1530];

5-(2-((3,3 -difluorocy clobutyl)amino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N-( 1 -methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1531];

5 -(2 -((( 1 -fluorocyclobuty l)methyl)amino) -7H-py rrolo [2,3 -d]py rimidin-5 -yl)-N -( 1 - methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1532];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1533];

5-(2-((c/.s-4-mcthoxycyclohcxyl)amino)-7H-pyrrolo|2.3-d|pyrimidin-5-yl)-N-( l-mcthylpipcridin- 4-yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1534] ;

5-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l- methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1535];

5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l- methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1536];

N-(l-methylpiperidin-4-yl)-5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1537];

N-( 1 -methylpiperidin-4-yl)-5 -(2-((( 1 -methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1538] ; N-(l-methylpiperidin-4-yl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1539];

5 -(2 -((3 -(4-methylpiperazin- 1 -yl)phenyl)amino) -7H-py rrolo [2, 3 -d] pyrimidin-5 -yl)-N-( 1 - methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1540];

N-(l-methylpiperidin-4-yl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1541];

5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l- methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1542];

5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l- methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1543];

5-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- N-(l-methylpiperidin-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1544];

N-( 1 -methylpiperidin-4-yl)-5 -(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1545];

5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1546];

N-(l-methylpiperidin-4-yl)-5-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1547] ;

5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [ 1 ,5 -a]pyridine-3 - carboxamide [1548];

5 -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [ 1 ,5 - a]pyridine -3 -carboxamide [1549];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1550];

5-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1551];

5-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methyl-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1552];

5 -(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [ 1 ,5 - a]pyridine -3 -carboxamide [1553];

5-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1554];

5 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1555]; 5-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1556];

5-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1557];

5-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1558];

5-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1559];

5-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1560];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1561];

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo[ 1 ,5 -a] pyridine -3 -carboxamide [1562] ;

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1563];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1564];

(R)-N-(tetrahydro-2H-pyran-4-yl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1565] ;

(S)-N-(tetrahydro-2H-pyran-4-yl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1566] ;

N-(tetrahydro-2H-pyran-4-yl)-5 -(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1567];

(S)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo[ 1 ,5 -a] pyridine -3 -carboxamide [1568] ;

5-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1569];

5-(2-(((l-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo[ 1 ,5 -a] pyridine -3 -carboxamide [1570] ;

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran- 4-yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1571 ] ;

5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo[ 1 ,5 -a] pyridine -3 -carboxamide [1572] ; N-(tetrahydro-2H-pyran-4-yl)-5-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1573] ;

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro- 2H-pyran-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1574];

5-(2-((3,3 -difluorocy clobutyl)amino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N -(tetrahy dro-2H-pyran- 4-yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1575] ;

5-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo[ 1 ,5 -a] pyridine -3 -carboxamide [1576] ;

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran- 4-yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1577];

5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo[ 1 ,5 -a] pyridine -3 -carboxamide [1578] ;

5-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo[ 1 ,5 -a] pyridine -3 -carboxamide [1579] ;

5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro- 2H-pyran-4-yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1580];

5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran- 4-yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1581];

5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro- 2H-pyran-4-yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1582];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1583] ;

5 -(2 -((3 -(4-methylpiperazin- 1 -yl)phenyl)amino) -7H-py rrolo [2, 3 -d] pyrimidin-5 -yl)-N - (tetrahy dro-2H-pyran-4-yl)pyrazolo [1,5 -a]pyridine -3 -carboxamide [1584];

5-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1585];

5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- (tetrahy dro-2H-pyran-4-yl)pyrazolo [1,5 -a]pyridine -3 -carboxamide [1586];

5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- (tetrahydro-2H-pyran-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1587];

5-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- N-(tetrahydro-2H-pyran-4-yl)pyrazolo[l,5-a]pyridine-3-carboxamide [1588];

5-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1589]; 5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1590];

5-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro- 2H-pyran-4-yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1591];

N-(pyridin-3 -y 1) -5 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [1592];

5-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo[l,5-a]pyridine-3- carboxamide [1593];

N-(pyridin-3 -y 1) -5 -(2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1594];

5-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo[l,5-a]pyridine-3- carboxamide [1595];

5 -(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 -yl)pyrazolo [1,5 -a]pyridine-3 - carboxamide [1596];

5 -(2 -(cy clobutylmethyl)-7H-py rrolo [2,3 -d]pyrimidin-5 -y 1) -N -(pyridin-3 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1597];

5-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo[l,5-a]pyridine-3- carboxamide [1598];

5-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo[l,5-a]pyridine- 3-carboxamide [1599];

5-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo[l,5-a]pyridine-3- carboxamide [1600];

5 -(2-(isopropylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1601];

5 -(2-(isobutylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 -yl)pyrazolo [1,5 -a]pyridine- 3-carboxamide [1602];

5 -(2 -(neopentylamino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N -(pyridin-3 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1603];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1604];

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1605];

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1606]; N-(pyridin-3 -y 1) -5 -(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1607];

(R)-N-(pyridin-3-yl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1608];

(S)-N-(pyridin-3-yl)-5-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1609];

N-(pyridin-3 -y 1) -5 -(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1610];

(S)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1611];

5 -(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 - carboxamide [1612];

5 -(2-((( 1 -fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1613];

(R)-5 -(2-(( 1 -cyclopropylethyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1614];

5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1615];

N-(pyridin-3-yl)-5-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y l)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [1616];

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1617];

5-(2-((3,3 -difluorocy clobutyl)amino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -N -(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1618];

5 -(2 -((( 1 -fluorocyclobuty l)methyl)amino) -7H-py rrolo [2,3 -d]py rimidin-5 -yl)-N -(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1619];

5 -(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1620];

5 -(2-((c/.s-4-mcthoxycyclohcxyl )am ino)-7H-py rrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1621];

5-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1622];

5 -(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1623]; 5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1624];

5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1625];

N-(pyridin-3-yl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1626];

5 -(2 -((3 -(4-methylpiperazin- 1 -yl)phenyl)amino) -7H-py rrolo [2, 3 -d] pyrimidin-5 -yl)-N -(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1627];

N-(pyridin-3 -y 1) -5 -(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridine -3 -carboxamide [1628];

5-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- (pyridin-3 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1629];

5-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- (pyridin-3 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1630];

5-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- N-(pyridin-3-yl)pyrazolo[ 1 ,5 -a]pyridine-3 -carboxamide [1631] ;

N-(pyridin-3 -y 1) -5 -(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine- 3-carboxamide [1632];

5-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo[l,5- a]pyridine -3 -carboxamide [1633];

5-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [1634];

5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1635];

2-isobutyl-5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1636] ;

5-(pyrazolo[l,5-a]pyrimidin-5-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidine [1637];

2-cyclopropyl-5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1638] ;

2-cyclobutyl-5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1639];

2-(cyclobutylmethyl)-5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1640] ;

5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1641 ] ;

N-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1642] ;

N-ethyl-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1643];

N-isopropyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1644] ;

N-isobutyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1645] ;

N-neopentyl-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1646]; (S)-N-(sec-butyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1647];

N-(2-fluoro-2-methylpropyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1648];

N-(2,2-difluoropropyl)-5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine

[1649];

5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1650];

(R)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1651];

(S)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1652];

5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1653];

(S)-N-( 1 -methoxypropan-2-yl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1654];

2-ethoxy-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidine [1655];

N-(( 1 -fluorocyclopropyl)methyl)-5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [1656];

(R)-N-( 1 -cyclopropylethyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1657];

N-(( 1 -methy ley clopropyl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1658];

5 -(pyrazolo [1,5 -a]pyrimidin-5 -y 1) -N-(( 1 -(trifluoromethyl)cyclopropyl)methy 1) -7H-py rrolo [2,3- d]pyrimidin-2-amine [1659];

N-(2 -cyclopropyl -2, 2-difluoroethyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1660];

N-(3 ,3 -difluorocyclobutyl) -5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1661];

N-(( 1 -fluorocyclobutyl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1662];

N-(4,4-difluorocyclohexyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1663];

N-(cis-4-methoxycyclohexyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1664];

646 N-(( 1 -fluorocyclohexyl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [1665];

N-((4,4-difluorocyclohexyl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1666];

N-( 1 -methylpiperidin-4-yl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1667];

N-(( 1 -methylpiperidin-4-yl)methyl)-5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1668];

5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1669];

N-(3-(4-methylpiperazin-l-yl)phenyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1670];

5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1671];

N-(2 -(4-methylpiperazin- 1 -yl)pyridin-4-y 1) -5 -(pyrazolo [1,5 -a]py rimidin-5 -yl)-7H-py rrolo [2,3- d]pyrimidin-2-amine [1672];

N-(6 -(4-methylpiperazin- 1 -yl)pyridin-3 -y 1) -5 -(pyrazolo [1,5 -a]py rimidin-5 -yl)-7H-py rrolo [2,3- d]pyrimidin-2-amine [1673];

N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)methyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1674];

6-(5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [1675] ;

4-( 1 -methyl- lH-pyrazol-4-yl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine

[1676];

N-(/ra«5-4-morpholinocyclohexyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-4-amine [1677];

N-(2-fluoro-2-methylpropyl)-5 -(3 -fluoropyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1678];

(R)-5-(3-fluoropyrazolo[l,5-a]pyrimidin-5-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1679];

5-(3-chloropyrazolo[l,5-a]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1680];

(R)-5 -(3 -chloropyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1681];

5 -(3 -cyclopropylpy razolo [1,5 -a]pyrimidin-5 -yl) -7H-pyrrolo [2,3 -d]pyrimidine [1682];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidine [1683] ; 5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 - d]pyrimidine [1684];

2-cyclopropyl-5 -(3 -cyclopropylpyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1685];

2-cyclobutyl-5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidine [1686];

2-(cyclobutylmethyl)-5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidine [1687];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [1688] ;

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-methyl-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [1689];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-ethyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1690];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-isopropyl-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1691];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1692];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-neopentyl-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1693];

(S)-N-(5ec-butyl)-5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1694];

5-(3-cyclopropylpyrazolo[l,5-a]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1695];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl) -N -(2,2-difluoropropy 1) -7H-pyrrolo [2,3- d]pyrimidin-2-amine [1696];

5-(3-cyclopropylpyrazolo[l,5-a]pyrimidin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1697];

(R)-5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1698];

(S)-5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [1699];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1700]; (S)-5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-( 1 -methoxypropan -2 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1701];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidine [1702] ;

5 -(3 -cyclopropylpyrazolo [ 1 ,5 -a]pyrimidin-5-yl)-N-(( 1 -fluorocyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1703] ;

(R)-N-(l-cyclopropylethyl)-5-(3-cyclopropylpyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1704];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(( 1 -methylcyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1705] ;

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1706] ;

N-(2 -cyclopropyl -2, 2-difluoroethyl)-5 -(3 -cyclopropylpyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1707] ;

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(3 ,3 -difluorocyclobutyl) -7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1708];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(( 1 -fluorocyclobutyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1709];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(4,4-difluorocyclohexyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1710];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl) -N -(c/.s-4-mc thoxy cyclohexyl) -7H-pyrrolo [2,3- d]pyrimidin-2-amine [1711];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(( 1 -fluorocyclohexyl)methyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1712];

5-(3-cyclopropylpyrazolo[l,5-a]pyrimidin-5-yl)-N-((4,4-difluorocyclohexyl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1713];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-( 1 -methylpiperidin-4-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1714];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(( 1 -methylpiperidin-4-yl)methyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1715];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [1716];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(3-(4-methylpiperazin- 1 -yl)phenyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1717]; -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [1718]; -(3 -cyclopropylpyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1719]; -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-N-(6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [1720] ; -(3 -cyclopropylpyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-N-((6-(4-methylpiperazin- 1 -yl)pyridin-3 - yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1721]; -(5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)quinoline [1722]; -(3 -cyclopropylpyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-4-( 1 -methyl- lH-pyrazol-4-yl)-7H-pyrrolo [2,3 - d]pyrimidine [1723]; -(3-cyclopropylpyrazolo[l,5-a]pyrimidin-5-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-4-amine [1724] ; -(7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4-dihydrobenzo [f] [ 1 ,4]oxazepin-5 (2H)-one [1725] ; -(2-isobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4-dihydrobenzo [f] [ 1 ,4]oxazepin-5 (2H)-one [1726]; -(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin- 5(2H)-one [1727]; -(2-cyclopropyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4-dihydrobenzo [f] [ 1 ,4]oxazepin-5 (2H)-one [1728]; -(2-cyclobutyl-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4-dihydrobenzo [f] [ 1 ,4]oxazepin-5 (2H)-one [1729]; -(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin- 5(2H)-one [1730]; -(2-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin-5(2H)-one [1731]; -(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin-5(2H)- one [1732]; -(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin-5(2H)- one [1733]; -(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin- 5(2H)-one [1734];

650 8-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin-5(2H)- one [1735];

8-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin- 5(2H)-one [1736];

(S)-8-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin- 5(2H)-one [1737];

8-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1738] ;

8-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1739] ;

8-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1740] ;

(R)-8-(2-(( 1,1, l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3 ,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1741] ;

(S)-8-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1742] ;

8-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1743] ;

(S)-8-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1744] ;

8-(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4-dihydrobenzo [f] [ 1 ,4]oxazepin-5 (2H)-one [1745];

8-(2-((( 1 -fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1746] ;

(R)-8-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1747];

8-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1748] ;

8-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1749] ;

8-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1750] ;

8-(2-((3 ,3 -difluorocy clobutyl)amino) -7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1751] ; -(2 -((( 1 -fluorocyclobuty l)methyl)amino) -7H-py rrolo [2,3 -d]py rimidin-5 -y 1) - 3 ,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1752] ; -(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1753] ; -(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1754] ; -(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1755] ; -(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1756] ; -(2-(( 1 -methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1757]; -(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1758] ; -(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1759] ; -(2 -((3 -(4-methylpiperazin- 1 -yl)phenyl)amino) -7H-py rrolo [2, 3 -d] pyrimidin-5 -y 1 ) -3 ,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1760] ; -(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin- 5(2H)-one [1761]; -(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1762] ; -(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1763] ; -(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- 3 ,4-dihydrobenzo [f] [ 1 ,4]oxazepin-5 (2H)-one [1764] ; -(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][l,4]oxazepin-5(2H)- one [1765]; -(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2, 3-d]pyrimidin-5-yl)-3 ,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1766] ; -(4-((/raM5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3 ,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [1767]; -(chroman-6-yl)-N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1768];

2.2-dimethyl-7 -(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)chroman-4-one [1769] ;

7-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1770];

2.2-dimethyl-7-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)chroman-4-one

[1771];

7-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1772];

7-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1773];

7-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1774];

7 -(2-amino-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-2,2-dimethylchroman -4-one [1775];

2.2-dimethyl-7-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)chroman-4-one [1776];

7-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1777];

7-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1778];

7-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1779];

2.2-dimethyl-7 -(2-(neopentylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)chroman-4-one [1780] ;

(S)-7-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1781];

7-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman- 4-one [1782];

7-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman -4-one [1783];

2.2-dimethyl-7-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)chroman-4-one [1784];

(R)-2,2-dimethyl-7-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)chroman-4-one [1785];

(S)-2,2-dimethyl-7-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)chroman-4-one [1786];

2.2-dimethyl-7 -(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)chroman-4- one [1787];

(S)-7-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2- dimethylchroman-4-one [1788];

7-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1789];

7 -(2-((( 1 -fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-2,2- dimethylchroman-4-one [1790];

(R)-7-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4- one [1791];

.2-dimethyl-7-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)chroman-4-one [1792]; .2-dimethyl-7-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5-yl)chroman-4-one [1793]; -(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2- dimethylchroman-4-one [1794]; -(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4- one [1795]; -(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2- dimethylchroman-4-one [1796]; -(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4- one [1797]; -(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman- 4-one [1798]; -(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2- dimethylchroman-4-one [1799]; -(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-2,2- dimethylchroman-4-one [1800]; .2-dimethyl-7-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)chroman-4- one [1801]; .2-dimethyl-7-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)chroman-4-one [1802]; .2-dimethyl-7-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)chroman-

4-one [1803]; .2-dimethyl-7-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)chroman-4-one [1804]; .2-dimethyl-7-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)chroman-4-one [1805]; .2-dimethyl-7 -(2-((2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-

5-yl)chroman-4-one [1806]; .2-dimethyl-7 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin- 5-yl)chroman-4-one [1807]; .2-dimethyl-7-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)chroman -4-one [1808] ; .2-dimethyl-7-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)chroman-4-one [1809];

2.2-dimethyl-7-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)chroman-4-one [1810];

2.2-dimethyl-7-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)chroman-4-one [1811];

4.4-dimethyl-6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-l(2H)-one [1812];

6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-l(2H)-one [1813];

4.4-dimethyl-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydroisoquinolin- 1 (2H) -one [1814];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-l(2H)- one [1815];

6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-l(2H)- one [1816];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin- l(2H)-one [1817];

6-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-l(2H)-one [1818];

4.4-dimethyl-6-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin- l(2H)-one [1819];

6-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-l(2H)- one [1820];

6-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin- l(2H)-one [1821];

6-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin- l(2H)-one [1822];

4.4-dimethyl-6-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin- l(2H)-one [1823];

(S)-6-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1824];

6-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1825];

6-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1826];

4.4-dimethyl-6-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydroisoquinolin- 1 (2H)-one [1827];

(R)-4,4-dimethyl-6-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydroisoquinolin- 1 (2H)-one [1828];

(S)-4,4-dimethyl-6-(2-((l,l,l-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydroisoquinolin- 1 (2H)-one [1829];

4.4-dimethyl-6-(2-((3 ,3 ,3 -trifluoropropyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -y 1) -3 ,4- dihydroisoquinolin- 1 (2H)-one [1830];

(S)-6-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H) -one [1831];

6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-l(2H)-one [1832];

6-(2-(((l-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1833];

(R)-6-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1834];

4.4-dimethyl-6-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydroisoquinolin- 1 (2H)-one [1835];

4.4-dimethyl-6-(2-(((l-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5-yl)-3,4-dihydroisoquinolin-l(2H)-one [1836];

6-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-

3 ,4-dihydroisoquinolin- 1 (2H)-one [1837] ;

6-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1838];

6-(2-(((l-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1839];

6-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1840];

6-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H) -one [1841];

6-(2-(((l-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [1842];

6-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-

3 ,4-dihydroisoquinolin- 1 (2H)-one [1843] ;

4.4-dimethyl-6-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydroisoquinolin- 1 (2H)-one [1844];

4.4-dimethyl-6-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-

3 ,4-dihydroisoquinolin- 1 (2H)-one [1845] ;

4.4-dimethyl-6-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydroisoquinolin- 1 (2H)-one [1846];

4.4-dimethyl-6-(2-((3-(4-methylpiperazin-l-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-

3 ,4-dihydroisoquinolin- 1 (2H)-one [1847] ;

4.4-dimethyl-6-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3 ,4-dihydroisoquinolin- l(2H)-one [1848];

4.4-dimethyl-6-(2-((2-(4-methylpiperazin-l-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5-yl)-3,4-dihydroisoquinolin-l(2H)-one [1849];

4.4-dimethyl-6-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)-7H-pyrrolo [2,3 -d]pyrimidin- 5-yl)-3,4-dihydroisoquinolin-l(2H)-one [1850];

4.4-dimethyl-6-(2-(((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -y 1) -3 ,4-dihydroisoquinolin- 1 (2H) -one [1851];

4.4-dimethyl-6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3 ,4-dihydroisoquinolin- l(2H)-one [1852];

4.4-dimethyl-6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydroisoquinolin- 1 (2H)-one [1853];

4.4-dimethyl-6-(4-((/ra«5-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-

3 ,4-dihydroisoquinolin- 1 (2H)-one [1854] ;

6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline [1855];

6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline [1856];

6-(2-isobutyl-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline [1857];

6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline [1858];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline [1859];

6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline [I860];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline [1861];

5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1862];

N-methyl-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1863];

N-ethyl-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1864];

N-isopropyl-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1865];

N-isobutyl-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1866]; N-neopentyl-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1867];

(S)-N-(sec-butyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1868];

N-(2-fluoro-2-methylpropyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1869];

N-(2,2-difluoropropyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1870];

5-(quinolin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1871];

(R)-5-(quinolin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1872];

(S)-5-(quinolin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1873];

5-(quinolin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1874];

(S)-N-(l-methoxypropan-2-yl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1875];

6-(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)quinoline [1876] ;

N-((l-fluorocyclopropyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1877];

(R)-N-(l-cyclopropylethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1878];

N-((l-methylcyclopropyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1879];

5-(quinolin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1880];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1881];

N-(3,3-difluorocyclobutyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1882];

N-((l-fluorocyclobutyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1883];

N-(4,4-difluorocyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1884];

N-(cis-4-methoxycyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1885];

N-((l-fluorocyclohexyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1886];

N-((4,4-difluorocyclohexyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1887];

N-(l-methylpiperidin-4-yl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1888];

N-((l-methylpiperidin-4-yl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[1889];

5-(quinolin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1890];

N-(3-(4-methylpiperazin-l-yl)phenyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[1891];

N-(pyridin-4-yl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1892];

N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1894]; N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1895];

6,6'-(7H-pyrrolo[2,3-d]pyrimidine-2,5-diyl)diquinoline [1896];

6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline [1897];

N-(/ra«5-4-morpholinocyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

[1898];

6-(2-methyl-4-((l-methylpiperidin-4-yl)methoxy)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoline

[1899];

6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1900];

6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1901];

6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1902];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1903];

6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1904];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1905];

5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1906] ;

N-methyl-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1907];

N-ethyl-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1908];

N-isopropyl-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1909];

N-isobutyl-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1910];

N-neopentyl-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1911];

(S)-N-(sec-butyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1912];

N-(2-fluoro-2-methylpropyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1913];

N-(2,2-difluoropropyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1914];

5-(quinoxalin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1915];

(R)-5 -(quinoxalin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine

[1916];

(S)-5-(quinoxalin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[1917];

5-(quinoxalin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1918];

(S)-N-( 1 -methoxypropan-2-yl)-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1919];

6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1920];

N-((l-fluorocyclopropyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1921];

(R)-N-(l-cyclopropylethyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1922]; N-((l-methylcyclopropyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1923];

5-(quinoxalin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1924];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1925];

N-(3 , 3 -difluorocyclobutyl) -5 -(quinoxalin-6-yl)-7H-py rrolo [2, 3 -d] pyrimidin-2-amine [1926];

N-((l-fluorocyclobutyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1927];

N-(4,4-difluorocyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1928];

N-(cis-4-methoxycyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1929];

N-(( 1 -fluorocyclohexyl)methyl)-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1930];

N-((4,4-difluorocyclohexyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1931];

N-(l-methylpiperidin-4-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1932];

N-((l-methylpiperidin-4-yl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1933];

5-(quinoxalin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1934];

N-(3-(4-methylpiperazin-l-yl)phenyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1935];

N-(pyridin-4-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1936];

N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1937];

N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1938];

N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1939];

6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1940];

6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1941];

N-(/raw.s-4-morpholinocyclohcxyl)-5-(qiiinoxalin-6-yl)-7H-pyrrolo|2.3-d|pyrimidin-4-aminc [1942];

6-(7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)quinazoline [1943] ;

6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1944];

6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1945];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1946]; 6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1947];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1948];

5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1949];

N-methyl-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1950];

N-ethyl-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1951];

N-isopropyl-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1952];

N-isobutyl-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1953];

N-neopentyl-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1954];

(S)-N-(sec-butyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1955];

N-(2-fluoro-2-methylpropyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1956];

N-(2,2-difluoropropyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1957];

5-(quinazolin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1958];

(R)-5-(quinazolin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1959];

(S)-5-(quinazolin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[I960];

5-(quinazolin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1961];

(S)-N-(l-methoxypropan-2-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1962];

6-(2-ethoxy-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)quinazoline [1963] ;

N-((l-fluorocyclopropyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[1964];

(R)-N-(l-cyclopropylethyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1965];

N-((l-methylcyclopropyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1966];

5-(quinazolin-6-yl)-N-((l-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1967];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[1968];

N-(3,3-difluorocyclobutyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1969];

N-((l-fluorocyclobutyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1970];

N-(4,4-difluorocyclohexyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1971];

N-(cis-4-methoxycyclohexyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1972];

N-((l-fluorocyclohexyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1973]; N-((4,4-difluorocyclohexyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1974];

N-(l-methylpiperidin-4-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1975];

N-((l-methylpiperidin-4-yl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1976];

5-(quinazolin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1977];

N-(3-(4-methylpiperazin-l-yl)phenyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1978];

N-(pyridin-4-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1979];

N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1980];

N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1981];

N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [1982];

6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1983];

6-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1984];

N-(/raw.s-4-morpholinocyclohcxyl)-5-(qiiinazolin-6-yl)-7H-pyrrolo|2.3-d|pyrimidin-4-aminc [1985];

5-(4-(4-methylpiperazin-l-yl)quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1986];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-(4-methylpiperazin-l-yl)quinazoline

[1987];

2-((l-methylpiperidin-4-yl)oxy)-7-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1988];

7-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-((l-methylpiperidin-4-yl)oxy)quinoxaline

[1989];

2-(( 1 -methylpiperidin-4-yl)oxy)-7-(2-(3 ,3 ,3 -trifluoropropyl)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)quinoxaline [1990];

7-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-((l-methylpiperidin-4-yl)oxy)quinoxaline [1991];

7-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-((l-methylpiperidin-4-yl)oxy)quinoxaline [1992];

7-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-((l-methylpiperidin-4- yl)oxy)quinoxaline [1993];

5 -(3 -(( 1 -methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [1994] ; N-methyl-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1995];

N-ethyl-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [1996];

N-isopropyl-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1997];

N-isobutyl-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1998];

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2- amine [1999]; and

(S)-N-(sec-butyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2000]; or a pharmaceutically acceptable salt thereof.

27. The compound according to any one of claims 1-22, wherein the compound of Formula I is selected from the group consisting of: N-(2-fhioro-2-methylpropyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2001];

N-(2,2-difhioropropyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2002];

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2003];

(R)-5 -(3 -(( 1 -methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2004] ;

(S)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2005] ;

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2006];

(S)-N-(l-methoxypropan-2-yl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2007] ;

7-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-((l-methylpiperidin-4-yl)oxy)quinoxaline

[2008];

N-((l-fhiorocyclopropyl)methyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2009] ;

(R)-N-(l-cyclopropylethyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2010]; N-((l-methylcyclopropyl)methyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2011];

5 -(3 -(( 1 -methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(( 1 -(trifluoromethyl)cyclopropyl)methyl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [2012];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2013];

N-(3 ,3 -difluorocyclobutyl) -5 -(3 -(( 1 -methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2014];

N-((l-fluorocyclobutyl)methyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2015];

N-(4,4-difluorocyclohexyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2016];

N-(cis-4-methoxycyclohexyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2017] ;

N-(( 1 -fluorocyclohexyl)methyl)-5 -(3 -((1 -methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2018];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2019];

N-( 1 -methylpiperidin-4-yl)-5 -(3 -(( 1 -methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2020];

N-((l-methylpiperidin-4-yl)methyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2021];

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2022] ;

N-(3-(4-methylpiperazin-l-yl)phenyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2023] ;

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2024];

N-(2-(4-methylpiperazin-l-yl)pyridin-4-yl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2025] ;

N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2026] ;

N-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)methyl)-5-(3-((l-methylpiperidin-4- yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2027]; 2-(( 1 -methylpiperidin-4-yl)oxy)-7-(2-(quinolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-5 - yl)quinoxaline [2028];

7-(4-(l-methyl-lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-((l-methylpiperidin-4- yl)oxy)quinoxaline [2029];

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(/ra«5-4-morpholinocyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-4-amine [2030] ;

N-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)-5 -(3 -(pyridin-3 -yl)pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2031];

(5 -(2-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin-3-yl)(4- methylpiperazin- 1 -yl)methanone [2032] ;

N-(cis-3-methoxycyclobutyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2033];

N-(c/.s-3 -mcthoxycyclobuty I )-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2034];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2035];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2036];

5 -(8 -fluoroimidazo [ 1 ,2-a |py ridm-6-yl )-N-(c/.s-3 -methoxy cyclobutyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2037];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2038];

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2039];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2040];

(8-fluoro-6-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[l,2- a]pyridin-3-yl)methanol [2041];

N-(2,2-difluoroethyl)-6-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridine-3 -carboxamide [2042] ;

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2043];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(cis-3-methoxycyclobutyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2044] ;

665 5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(cis-3- methoxycyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2045];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2046] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-3-methoxycyclobutyl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2047] ;

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-3-methoxycyclobutyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2048] ;

5 -([ 1 ,2,4]triazolo [ 1 .5 -a | py ridm-6-yl )-N-(c/.s-3 -methoxy cyclobutyl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [2049];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2050];

N-(cis-3-methoxycyclobutyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2051];

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2052];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2053];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(cis-3 -methoxy cyclobutyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2054];

N-(cis-3-methoxycyclobutyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2055];

N-(cis-3-methoxycyclobutyl)-5-(3-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2056];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2057] ;

N-(c/.s-3 -mcthoxycyclobutyl )-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [2058];

N-(cis-3-methoxycyclobutyl)-5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2059] ;

(5 -(2-((c/.s-3 -mcthoxycyclobutyl )am i no)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [1,5- a]pyridin-3 -yl)(piperidin- 1 -yl)methanone [2060] ;

N-(2.2-difluorocthyl)-5-(2-((c/.s-3-mcthoxycyclobutyl)amino)-7H-pyrrolo|2.3-d|pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [2061]; N-(2-fluoro-2-methylpropyl)-5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2062] ;

5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((R)-l,l,l- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [2063] ;

N-(3,3-difluorocyclobutyl)-5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [2064] ;

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2065] ;

5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(cis-4- methoxycyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [2066] ;

5-(2-((c/.s-3-mcthoxycyclobiityl)amino)-7H-pyrrolo|2.3-d|pyrimidin-5-yl)-N-( l-mcthylpipcridin- 4-yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2067] ;

5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo[ 1 ,5 -a] pyridine -3 -carboxamide [2068] ;

5 -(2-((CZ5-3 -methoxy cyclobutyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)-N-(pyridin-3 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [2069] ;

N-(cis-3 -methoxy cyclobutyl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [2070];

5 -(3 -cyclopropylpyrazolo [1,5 -a]pyrimidin-5 -yl) -N -(cis-3 -methoxy cyclobutyl)-7H-py rrolo [2,3- d]pyrimidin-2-amine [2071];

8-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4]oxazepin-5(2H)-one [2072] ;

7-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman- 4-one [2073];

6-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H)-one [2074];

N-(cis-3-methoxycyclobutyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2075];

N-(cis-3-methoxycyclobutyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2076];

N-(cis-3-methoxycyclobutyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2077];

N-(cis-3-methoxycyclobutyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2078] ;

5-(2-methylbenzo[d]thiazol-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2079]; 5-(thieno[3,2-c]pyridin-2-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2080];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2081];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2082];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2083];

5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2084] ;

5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2085] ;

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2086] ;

(8-fluoro-6-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[ 1 ,2-a]pyridin-3 -yl)methanol [2087] ;

N-(2,2-difluoroethyl)-6-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)imidazo [ 1 ,2-a]pyridine-3 -carboxamide [2088] ;

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2089];

5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(cis-4-(trifluoromethoxy) cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2090];

5-(4-fluoro-2-methyl-l-(l-methylpiperidin-4-yl)-lH-benzo[d]imidazol-6-yl)-N-(cis-4- (trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2091];

5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy) cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2092];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-4-(trifluoromethoxy) cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2093];

5-(3-isopropyl-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-4-(trifluoromethoxy) cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2094];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2095];

5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2096] ; 5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2097] ;

5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2098] ;

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2099];

5-(3-chloroimidazo[l,2-b]pyridazin-6-yl)-N-(czf-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2100];

5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2101];

5-(3 -methylimidazo [ 1 ,2-b ] pyridazin-6-yl)-N-(c/.s-4-(trifluoromcthoxy)cyclohcxyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2102];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2103];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl ) - N -(cz.s-4 -( t r i fl uoromethoxy )cyclohexyl )-7H-py rrolo [2,3 - d]pyrimidin-2-amine [2104];

5 -(3 -( 1 -methyl- lH-pyrazol-4-yl)pyrazolo [ 1 ,5 -a]pyridin-5 -y 1 )-N-(c/.s-4-(trifl no romethoxy ) cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2105]; piperidin-l-yl(5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridin-3 -yl)methanone [2106];

N-(2,2-difluoroethyl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2107] ;

N-(2-fluoro-2-methylpropyl)-5-(2-((czf-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2108] ;

5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((R)- 1, 1, l-trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [2109];

N-(3,3-difluorocyclobutyl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2110];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((czf-4-(trifluoromethoxy)cyclohexyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2111];

N-((lr,4r)-4-methoxycyclohexyl)-5-(2-((czf-4-(trifluoromethoxy)cyclohexyl)amino)-7H- pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2112];

N-( I -mcthylpipcridin-4-yl)-5-(2-((c/.s-4-(trifliioromcthoxy)cyclohcxyl)amino)-7H-pyrrolo|2.3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2113]; N-(tetrahydro-2H-pyran-4-yl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2114];

N-(pyridin-3-yl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin- 5 -yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [2115];

5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2116];

5-(3-cyclopropylpyrazolo[l,5-a]pyrimidin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2117];

8-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4- dihydrobenzo [f] [ 1 ,4] oxazepin-5 (2H)-one [2118];

2,2-dimethyl-7-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)chroman-4-one [2119];

4,4-dimethyl-6-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)-3 ,4-dihydroisoquinolin- 1 (2H)-one [2120] ;

5-(quinolin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[2121];

5-(quinoxalin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[2122];

5-(qiiinazolin-6-yl)-N-(c/.s-4-(trifliioromcthoxy)cyclohcxyl)-7H-pyrrolo|2.3-d|pyrimidin-2-aminc

[2123];

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2124];

N-(cis-4-ethoxycyclohexyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2125];

N-(c/.s-4-cthoxycyclohcxyl )-5 -(thieno [3 ,2-c]pyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine

[2126];

N-(c/.s-4-cthoxycyclohcxyl)-5-(imidazo| l.2-a|pyridin-6-yl)-7H-pyrrolo|2.3-d|pyrimidin-2-aminc [2127];

N-(c/.s-4-cthoxycyclohcxyl )-5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [2128];

N-(cis-4-ethoxycyclohexyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [2129];

N-(cis-4-ethoxycyclohexyl)-5-(8-fluoro-2-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2130]; N-(cis-4-ethoxycyclohexyl)-5-(8-fluoro-3-methylimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2131];

5-(3-(difluoromethyl)imidazo[l,2-a]pyridin-6-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo [2,3- d]pyrimidin-2-amine [2132];

(6-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo [1,2- a]pyridin-3-yl)methanol [2133];

N-(2,2-difluoroethyl)-6-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)imidazo[l,2-a]pyridine-3-carboxamide [2134];

N-(cis-4-ethoxycyclohexyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2135];

N-(cis-4-ethoxycyclohexyl)-5-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2136];

N-(cis-4-ethoxycyclohexyl)-5-(4-fluoro-2 -methyl- 1 -( 1 -methylpiperidin-4-yl)- 1H- benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2137];

N-(cis-4-ethoxycyclohexyl)-5-(l-isopropyl-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2138];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-4-ethoxycyclohexyl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [2139];

N-(c/.s-4-cthoxycyclohcxyl )-5 -(3 -isopropyl -2 -methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2140];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2141];

N-(cis-4-ethoxycyclohexyl)-5-(8-fluoro-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2142];

N-(cis-4-ethoxycyclohexyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2143];

N-(cis-4-ethoxycyclohexyl)-5-(l-ethyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2144];

N-(cis-4-ethoxycyclohexyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2145];

5 -(3 -chloroimidazo [ 1 ,2-b]pyridazin-6-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2146];

N-(cis-4-ethoxycyclohexyl)-5-(2-methylimidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2147]; N-(c/.s-4-cthoxycyclohcxyl )-5 -(3 -methylimidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2148];

5-(3-(difluoromethyl)imidazo[l,2-b]pyridazin-6-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2149];

N-(cis-4-ethoxycyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2150];

N-(cis-4-ethoxycyclohexyl)-5-(3-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2151];

(5 -(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3 -d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridin- 3-yl)(piperidin- 1 -yl)methanone [2152] ;

N-(2,2-difluoroethyl)-5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [2153];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2- methylpropyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [2154];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-((R)-l,l,l- trifluoropropan-2-yl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [2155] ;

N-(3 , 3 -difluorocyclobutyl) -5 -(2-(((cis-4 -ethoxycy clohexyl)amino) -7H-pyrrolo [2, 3 -d]pyrimidin-5 - yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [2156];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5 -yl)pyrazolo [ 1 ,5 -a]pyridine-3 -carboxamide [2157] ;

5-(2-((c/.s-4-cthoxycyclohcxyl)amino)-7H-pyrrolo|2.3-d|pyrimidin-5-yl)-N-(( I r.4r)-4- methoxy cyclohexyl)pyrazolo [1,5 -a]pyridine-3 -carboxamide [2158] ;

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(l-methylpiperidin-4- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [2159];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H- pyran-4-yl)pyrazolo [ 1 ,5 -a] pyridine -3 -carboxamide [2160];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-3- yl)pyrazolo [1,5 -a]py ridine -3 -carboxamide [2161];

N-(c/.s'-4-cthoxycyclohcxyl )-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [2162];

5 -(3 -cyclopropylpyrazolo [1,5 -a |py rim idi n-5 -yl )-N-(c/.s-4-cthoxycyclohcxyl )-7H-py rrolo [2,3 - d]pyrimidin-2-amine [2163];

8-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f][l,4]oxazepin-5(2H)-one [2164]; 7-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4- one [2165];

6-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4- dihydroisoquinolin- 1 (2H) -one [2166];

N-(cis-4-ethoxycyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2167];

N-(cis-4-ethoxycyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2168];

N-(cis-4-ethoxycyclohexyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2169];

N-(cis-4-ethoxycyclohexyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2170];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(cis-4-(methoxy-d3)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [2171];

N-(cis-4-(methoxy-d3)cyclohexyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2172];

N-(cis-4-(methoxy-d3)cyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[2173];

(R)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2174];

(R)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2175];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2176];

(R)-4-ethoxy-5 -(imidazof 1 ,2-a]pyridin-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2177];

(R)-2-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-2-(( 1,1,1 -trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3 - d]pyrimidin-4-yl)oxy)ethan- 1 -ol [2178];

CZ5-4-((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2179];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(cis-4-(methoxy-J3)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2180];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2181];

2-((cis-4-((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2182] ; (R)-5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-N-( 1,1,1 -trifluoropropan -2 -yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2183];

(R)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(l-methoxypropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2184];

N-(4,4-difluorocyclohexyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2185]; czs-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2186];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2187];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2188];

(R)-4-ethoxy-5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-( 1,1,1 -trifluorop ropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2189]; c7s-4-((4-ethoxy-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2190]; c/.s- 1 -mcthyl-4-((5-( l-mcthyl-l H-bcnzo|d|| 1.2.3 |triazol-6-yl)-7H-pyrrolo| 2.3-d |pyrimidin-2- yl)amino)cyclohexan-l-ol [2191];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2192];

(R)-4-methoxy-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2193];

(R)-4-methoxy-N-( 1 -methoxypropan-2-yl)-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2194];

4-methoxy-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-N-( 1 -methylpiperidin-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2195];

(R)-4-ethoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2196]; c/.s-4-((4-cthoxy-5-( l-mcthyl-l H-bcnzo|d|| 1.2.3 |triazol-6-yl)-7H-pyrrolo|2.3-d|pyrimidin-2- yl)amino)cyclohexan-l-ol [2197];

N-(4,4-difluorocyclohexyl)-5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [2198];

N-(c/.s-4-(2.2-difluorocthoxy)cyclohcxyl)-5-(imidazo| l.2-b|pyridazin-6-yl)-7H-pyrrolo|2.3- d]pyrimidin-2-amine [2199]; N-(cis-4-(methoxy-J3)cyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2200];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2201];

2-((CZ5-4-((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2202] ;

N-(c/.s-4-(2-mcthoxycthoxy [cyclohcxyl )-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2203];

(R)-4-methoxy-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2204];

(R)-4-methoxy-N-( 1 -methoxypropan-2-yl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2205];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2206]; c/.s-4-((4-mcthoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2207]; c/.s-4-((4-mcthoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2208];

/raws-4-((4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexan-l-ol [2209];

4-methoxy-N-(cis-4-(methoxy-J3)cyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2210];

N-(cis-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2211];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2212];

2-((cis-4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2213] ;

4-methoxy-N-(cis-4-(2-methoxyethoxy)cyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2214];

4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2215];

4-methoxy-N-( 1 -methylpiperidin-4-yl)-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2216]; 4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2217];

(R)-4-ethoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-N-(l,l,l-trifluoropropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2218]; c/.s-4-((4-cthoxy-5 -(pyrazolo [1,5 -a]pyridin-5-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2219]; c/5-4-((4-isopropoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2220];

N-(c/s-4-(methoxy-tiG)cyclohexyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2221];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2222];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2223];

4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2224]; cis -4-((4-ethoxy-5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2225];

N-(cis-4-(2-methoxyethoxy)cyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine

[2226];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[2227]; cis- 1 -methyl -4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol

[2228];

2-((CZ5-4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 - ol [2229];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2230]; c7s-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcy clohexan- 1 -ol [2231]; c/.s-4-((4-cthoxy-5-(qiiinoxalin-6-yl)-7H-pyrrolo|2.3-d|pyrimidin-2-yl)amino)cyclohcxan-l-ol [2232]; c/.s-4-((5-(imidazo| l.2-a|pyridin-6-yl)-4-mcthoxy-7H-pyrrolo|2.3-d|pyrimidin-2-yl)amino)-l- methylcyclohexan-l-ol [2233];

676 c/5-l-methyl-4-((5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2234];

C/5-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2235];

/ram-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2236]; trans-4-((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2237]; trans- 1 -methyl -4-((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2238]; cis-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2239] ;

N-(2-fluoro-2-methylpropyl)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2240];

N-(4,4-difluorocyclohexyl)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2241];

5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-(methoxy-J3)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2242];

5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(/ra«5-4-(methoxy-<73)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2243];

N-(cis-4-(difluoromethoxy)cyclohexyl)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2244] ;

N-(/ra«5-4-(difluoromethoxy)cyclohexyl)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2245] ;

5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2246] ;

/ram-4-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexan-l-ol [2247];

5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-methoxy-4-methylcyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2248] ;

/ram- l -cthyl-4-((5-(imidazo| l .2-a|pyridin-6-yl)-4-mcthoxy-7H-pyrrolo|2.3-d|pyrimidin-2- yl)amino)cyclohexan-l-ol [2249];

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-N-( 1 ,5 -dioxaspiro [5.5 ]undecan-9-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2250]; N-(5,12-dioxadispiro[2.2.56.23]tridecan-9-yl)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2251];

N-((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2252] ;

N-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2253] ; cz5-4-((4-ethoxy-5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2254];

N-(2-fluoro-2-methylpropyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2255];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-(methoxy-J3)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2256] ;

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(/ra«5-4-(methoxy-J3)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2257] ;

N-(cis-4-(difluoromethoxy)cyclohexyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2258] ;

N-(/ra«5-4-(difluoromethoxy)cyclohexyl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2259] ;

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2260] ;

/raws-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2261];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-methoxy-4-methylcyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2262] ;

/raws-l-ethyl-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)cyclohexan- 1 -ol [2263] ;

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-N-( 1 ,5 -dioxaspiro [5.5 ]undecan-9-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2264] ;

N-(5,12-dioxadispiro[2.2.56.23]tridecan-9-yl)-5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2265] ;

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2266];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2267];

678 N-(4,4-difluorocyclohexyl)-5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2268];

5-(l -(2, 2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(2-fluoro-2 -methylpropyl)- 4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2269];

(R)-5 -( 1 -(2,2-difluoroethyl)-2-methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-4-methoxy-N-( 1,1,1- trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2270];

(R)-5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-(l- methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2271];

N-(4,4-difluorocyclohexyl)-5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2272];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-(cis-4-(methoxy- Jj)cyclohcxyl)-7H-pyrrolo|2.3-d|pyrimidin-2-aminc [2273];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(cis-4-

(difluoromethoxy)cyclohexyl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2274];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-(cis-4- (trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2275];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(2-fluoro-2 -methylpropyl)- 4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2276];

(R)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-methoxy-N-( 1,1,1 - trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2277];

(R)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-methoxy-N-(l- methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2278];

N-(4,4-difluorocyclohexyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2279];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-methoxy-N-(cis-4-(methoxy- Jj)cyclohcxyl)-7H-pyrrolo|2.3-d|pyrimidin-2-aminc [2280];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-4-

(difluoromethoxy)cyclohexyl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2281];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-methoxy-N-(cis-4- (trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2282];

N-(2-fluoro-2-methylpropyl)-4-methoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2283] ;

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2284] ; 4-methoxy-N-(cis-4-(methoxy-J3)cyclohexyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2285] ;

4-mcthoxy-N-(/ram-4-(mcthoxy-J,)cyclohcxyl )-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2286] ;

N-(c/.s-4-(difl uoromcthoxy )cyclohcxyl )-4-mcthoxy-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2287] ;

N-(/ra«5-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2288];

4-methoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3 ]tri azol -6-yl )-N-(c/.s-4-(trifluoromcthoxy )cyclohexyl )- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2289] ;

4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(l,5-dioxaspiro[5.5]undecan-9-yl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2290] ;

N-(5,12-dioxadispiro[2.2.56.23]tridecan-9-yl)-4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol- 6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2291 ] ;

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-N-(2-fluoro-2-methylpropyl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2292];

(R)-5-( 1 -(2, 2-difluoroethyl)- lH-benzo[d] [ 1 ,2, 3]triazol-6-yl)-4-methoxy -N-( 1 , 1 , 1 -trifluoropropan- 2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2293] ;

(R)-5-( 1 -(2, 2-difluoroethyl)- lH-benzo[d] [ 1 ,2, 3]triazol-6-yl)-4-methoxy -N-( 1 -methoxypropan-2- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2294];

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-N-(cis-4-(methoxy- Jj)cyclohcxyl)-7H-pyrrolo|2.3-d|pyrimidin-2-aminc [2295];

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-N-(cis-4-(difluoromethoxy)cyclohexyl)- 4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2296];

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-N-(cis-4- (trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2297];

N-(2-fluoro-2-methylpropyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2298];

(R)-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-4-methoxy-N-( 1,1,1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2299];

(R)-5-(imidazo[l,2-b]pyridazin-6-yl)-4-methoxy-N-(l-methoxypropan-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2300];

N-(4,4-difluorocyclohexyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2301]; 5-(imidazo[l,2-b]pyridazin-6-yl)-4-methoxy-N-(cis-4-(methoxy-J3)cyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2302];

N-(cis-4-(difluoromethoxy)cyclohexyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2303] ;

5-(imidazo[l,2-b]pyridazin-6-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2304] ;

N-(2-fluoro-2-methylpropyl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2305];

4-methoxy-N-(cis-4-methoxycyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2306];

4-mctlwxy-N-(/ram-4-(mctlwxy-Jj)cyclohcxyl)-5-(pyrazolo| l.5-a|pyridin-5-yl)-7H-pyrrolo|2.3- d]pyrimidin-2-amine [2307];

N-(/ra«5-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2308] ;

4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2309] ;

4-methoxy-N-(cis-4-methoxy-4-methylcyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2310];

/ra«5-l-ethyl-4-((4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2311];

4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-N-(l,5-dioxaspiro[5.5]undecan-9-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2312];

N-(5,12-dioxadispiro[2.2.56.23]tridecan-9-yl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2313];

(R)-4-methoxy-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-(tetrahydro-2H-pyran-3 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2314];

(S)-4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(tetrahydro-2H-pyran-3 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2315];

N-((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2316];

N-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2317] ;

(3 S,4R)-4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)tetrahydro-2H-pyran-3 -ol [2318] ;

681 4-methoxy-N-((3S,4R)-3-methoxytetrahydro-2H-pyran-4-yl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2319]; cz5-4-((4-isopropoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2320];

(R)-4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(tetrahydrofuran-3 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2321];

(S)-4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(tetrahydrofuran-3 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2322];

N-((lR,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2323] ;

N-((lR,5S,6s)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2324] ;

N-(2-fluoro-2-methylpropyl)-4-methoxy-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2325];

(R)-4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-N-( 1 , 1 , 1 -trifluoropropan-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2326];

(R)-4-methoxy-N-( 1 -methoxypropan-2-yl)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2327];

4-methoxy-N-(cis-4-(methoxy-J3)cyclohexyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2328];

N-(cis-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2329] ;

4-methoxy-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2330] ;

( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [2331];

(lr,3r)-3-((5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [2332] ;

(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2333] ;

(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2334] ;

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [2335] ;

682 N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [2336] ;

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [2337] ;

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [2338] ; l-((lr,3r)-3-((5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)pyrrolidin-2-one [2339] ;

1 -(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [2340] ;

( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [2341];

(lr,3r)-3-((5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [2342];

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane - 1 -carboxamide [2343] ;

(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2344];

N-(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2345] ;

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2346] ;

1 -(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2347] ;

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexyl)acetamide [2348] ;

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2349];

( 1 s,4s)- 1 -ethyl -4-((5 -(imidazof 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2350];

1 -(4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)piperidin- 1 - yl)ethan-l-one [2351];

(S)-5 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2352]; (R)-5 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2353];

1 -(2 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 - azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2354] ; l-((3aR,5s,6aS)-5-((5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2355] ; l-((3aR,5r,6aS)-5-((5-(imidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2356] ;

1 -(7 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [2357];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2358];

5-(imidazo[l,2-a]pyridin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [2359];

( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2360] ;

(lr,3r)-3-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2361 ] ;

((ls,3s)-3-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2362] ;

(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2363] ;

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [2364] ;

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [2365] ;

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2366] ;

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2367] ; l-((lr,3r)-3-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2368] ;

1 -(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2369] ; (lr,3r)-3-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [2370];

( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [2371];

(ls,4s)-4-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- N,N-dimethylcyclohexane-l -carboxamide [2372];

((ls,4s)-4-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2373];

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2374] ;

N-((ls,4s)-4-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2375] ;

1 -(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2376];

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [2377] ;

(lr,4r)-4-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexan-l-ol [2378];

( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a ] py ridin -6-yl )-4-(mcthoxy-J,)-7H-py rrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclohexan- 1 -ol [2379] ;

(ls,4s)-4-((5-(imidazo[l,2-a]pyridin-6-yl)-4-(methoxy-tiG)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2380] ;

( 1 s,4s)- 1 -ethyl -4-((5 -(imidazof 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2381];

1 -(4-((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [2382] ;

(S)-5 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2383];

(R)-5 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2384];

1 -(2 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 - azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2385] ;

1 -((3aR,5 s,6aS)-5 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2386] ; l-((3aR,5r,6aS)-5-((5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2387] ;

1 -(7 -((5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [2388];

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-N-(2 -oxaspiro [3.5]nonan-7 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2389];

5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2390];

( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2391 ] ;

( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2392];

(( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2393] ;

(( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2394] ;

N-(( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [2395] ;

N-(( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [2396] ;

N-(( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [2397] ;

N-(( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [2398] ;

1 -(( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [2399] ;

1 -(( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [2400] ;

( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [2401];

( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [2402];

(( 1 s,4s)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2403]; ( 1 s,4s)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2404];

( 1 r,4r)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2405]; l-(4-((5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin- l-yl)ethan-l-one [2406];

(S)-5 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2407];

(R)-5 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2408];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2409];

( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2410];

( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2411];

(( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl) (pyrrolidin- 1 -y l)methanone [2412];

(( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2413] ;

N-(( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [2414];

N-(( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [2415];

N-(( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2416];

N-(( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2417];

1 -(( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2418] ;

1 -(( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2419] ;

( 1 s,3 s)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutan- 1 -ol [2420] ; ( 1 r,3r)-3 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutan- 1 -ol [2421] ;

( 1 s,4s)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) -N,N -dimethylcyclohexane - 1 -carboxamide [2422] ;

(( 1 s,4s)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2423];

N-(( 1 r,4r)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2424] ;

N-((ls,4s)-4-((5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2425] ;

1 -(( 1 s,4s)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2426] ;

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-N-(( 1 s,4s)-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2427] ;

2-(((lr,4r)-4-((5 -(3 -fluoroimidazo [l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2, 3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2428] ;

2-((( 1 s,4s)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2429] ;

N-(( 1 r,4r)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [2430] ;

( 1 s,4s)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclohexan- 1 -ol [2431] ;

( 1 r,4r)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2432] ;

( 1 s,4s)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a | py ridm-6-yl )-4-(mcthoxy-J,)-7H-py rrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2433] ;

( 1 r,4r)-4-((5 -(3 -fluoroimidazo [ 1 ,2-a ] py ridin -6-yl )-4-(mcthoxy-J,)-7H-py rrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2434] ;

( 1 s,4s)- 1 -ethyl -4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol [2435] ;

1 -(4-((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [2436] ;

(R)-5 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [2437] ; (S)-5 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [2438] ;

1 -(2 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) -7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2439] ; l-((3aR,5s,6aS)-5-((5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2440] ; l-((3aR,5r,6aS)-5-((5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2441];

1 -(7 -((5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-l-one [2442];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-N-(2 -oxaspiro [3.5]nonan-7 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2443] ;

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2444] ;

( 1 s,3 s)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2445];

(lr,3r)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-

N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2446];

((ls,3s)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2447] ;

(( 1 r,3r)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2448] ;

N-((ls,3s)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)acetamide [2449] ;

N-((lr,3r)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcy clobutyl)acetamide [2450] ;

N-((ls,3s)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcy clobutyl)propionamide [2451];

N-((lr,3r)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcy clobutyl)propionamide [2452] ;

1 -(( 1 r,3r)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)pyrrolidin -2 -one [2453] ;

1 -(( 1 s,3 s)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)pyrrolidin -2 -one [2454] ; (lr,3r)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [2455];

( 1 s,3 s)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [2456];

(ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane- 1 -carboxamide [2457] ;

((ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2458];

N-((lr,4r)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2459] ;

N-((ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2460] ;

1 -(( 1 s,4s)-4-((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2461];

2-((( 1 r,4r)-4-((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2462] ;

N-((lr,4r)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexyl)acetamide [2463] ;

( 1 s,4s)- 1 -ethyl -4-((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2464]; l-(4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin- l-yl)ethan-l-one [2465];

(R)-5-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylpiperidin-2-one [2466];

(S)-5-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylpiperidin-2-one [2467]; l-(2-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2468] ;

1 -((3aR,5 s,6aS)-5 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2469] ; l-((3aR,5r,6aS)-5-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2470] ; l-(7-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2- azaspiro[3.5]nonan-2-yl)ethan-l-one [2471]; 5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-(2 -oxaspiro [3.5]nonan-7 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2472];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2473];

( 1 s,3 s)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2474];

(lr,3r)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2475];

((ls,3s)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2476] ;

(( 1 r,3r)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2477] ;

N-(( 1 s,3 s)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)acetamide [2478] ;

N-(( 1 r,3r)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)acetamide [2479] ;

N-(( 1 s,3 s)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2480] ;

N-(( 1 r,3r)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2481];

1 -(( 1 s,3 s)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2482] ;

1 -(( 1 r,3r)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2483] ;

( 1 s,3 s)-3 -((5 -(8-fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutan- 1 -ol [2484] ;

(lr,3r)-3-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclobutan- 1 -ol [2485] ;

(ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) -N,N -dimethylcyclohexane - 1 -carboxamide [2486] ;

((ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2487];

N-((lr,4r)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2488] ; N-((ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2489] ;

1-((ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2490] ;

2-(((lr,4r)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2491] ;

2-(((ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2492] ;

N-((lr,4r)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [2493] ;

(lr,4r)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2494] ;

(ls,4s)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-(methoxy-<3G)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2495] ;

(lr,4r)-4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-(methoxy-<3G)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2496] ;

( 1 s,4s)- 1 -ethyl-4-((5-(8-fluoroimidazo[ 1 ,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol [2497] ; l-(4-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [2498] ;

(S)-5-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [2499] ;

(R)-5-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)-l-methylpiperidin-2-one [2500]; or a pharmaceutically acceptable salt thereof.

28. The compound according to any one of claims 1-22, wherein the compound of Formula I is selected from the group consisting of: l-(2-((5-(8-fhioroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) -7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2501 ] ; l-((3aR,5s,6aS)-5-((5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2502] ; l-((3aR,5r,6aS)-5-((5-(8-fhioroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2503] ; l-(7-((5-(8-fhioroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-l-one [2504]; 5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-N-(2 -oxaspiro [3.5]nonan-7 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2505] ;

( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [2506] ;

(lr,3r)-3-((5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [2507] ;

((ls,3s)-3-((5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2508] ;

(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2509] ;

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [2510];

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)acetamide [2511];

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)propionamide [2512];

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)propionamide [2513];

1 -(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)pyrrolidin -2 -one [2514] ;

1 -(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)pyrrolidin-2 -one [2515] ;

(lr,3r)-3-((5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [2516];

( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [2517];

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane - 1 -carboxamide [2518];

((ls,4s)-4-((5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2519];

N-((ls,4s)-4-((5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2520] ;

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2521] ; 1 -(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2522] ;

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexyl)acetamide [2523] ;

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2524];

( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2525];

( 1 s,4s)- 1 -ethyl -4-((5 -(imidazof 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2526];

1 -(4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)piperidin- 1 - yl)ethan-l-one [2527];

(S)-5 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2528];

(R)-5 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2529];

1 -(2 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 - azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2530] ;

1 -((3aR,5 s,6aS)-5 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2531] ; l-((3aR,5r,6aS)-5-((5-(imidazo[l,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2532] ;

1 -(7 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [2533];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-(2-oxaspiro [3.5]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [2534];

5-(imidazo[l,2-a]pyrimidin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [2535];

( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2536];

( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2537];

((ls,3s)-3-((5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2538] ; (( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2539] ;

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [2540] ;

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [2541];

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2542] ;

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2543] ;

1 -(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2544] ;

1 -(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2545] ;

( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutan- 1 -ol [2546] ;

( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutan- 1 -ol [2547] ;

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) -N,N -dimethylcyclohexane - 1 -carboxamide [2548] ;

((ls,4s)-4-((5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2549];

N-(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2550] ;

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2551] ;

1 -(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2552] ;

5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-N-((ls,4s)-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2553];

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [2554] ;

( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2555] ; ( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2556] ;

(lr,4r)-4-((5-(imidazo[l,2-a]pyrimidin-6-yl)-4-(methoxy-d3)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclohexan- 1 -ol [2557] ;

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-a | py ri m idi n-6-y I )-4-(mcthoxy-J,)-7H-py rrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2558] ;

( 1 s,4s)- 1 -ethyl -4-((5 -(imidazof 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2559];

1 -(4-((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [2560] ;

(S)-5-((5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylpiperidin-2-one [2561];

(R)-5 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2562]; l-(2-((5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2563] ;

1 -((3aR,5 s,6aS)-5 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2564] ; l-((3aR,5r,6aS)-5-((5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2565] ;

1 -(7 -((5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [2566];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-4-methoxy-N-(2-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [2567];

5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2568];

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2569] ;

(Ir, 3r)-3-((5-(l-(2, 2-difluoroethyl)-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2, 3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2570] ;

((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2571];

((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2572]; N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2573] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2574] ;

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2575] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2576] ; l-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2577] ; l-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2578] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2579] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2580] ;

( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [2581] ;

((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2582] ;

N-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2583] ;

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2584] ;

1-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2585] ;

2-(((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2586] ;

2-(((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2587] ;

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclohexyl)acetamide [2588] ;

(Ir, 4r)-4-((5-(l-(2, 2-difluoroethyl)-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2, 3- d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2589] ; ( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2590] ;

( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [2591] ; l-(4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [2592] ;

(S)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2593] ;

(R)-5 -((5 -( 1 -(2,2-difluoroethyl)-2-methyl- IH-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2594] ; l-(2-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino) -7 -azaspiro [3.5 ]nonan-7 -y l)ethan- 1 -one [2595] ; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2596]; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2597];

1 -(7 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-l-one [2598];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2599] ;

5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2600] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l-trimethylcyclobutane-l-carboxamide [2601];

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2602] ;

((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2603];

((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2604];

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)acetamide [2605]; N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)acetamide [2606];

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2607] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2608] ; l-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2609] ; l-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)pyrrolidin-2-one [2610];

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2611];

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutan-l-ol [2612];

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-l-carboxamide [2613];

(( 1 s,4s)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-benzo [d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2614];

N-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2615];

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2616];

1-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2617];

2-(((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [2618];

2-(((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [2619];

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexyl)acetamide [2620] ;

( I r.4r)-4-((5-( l-(2.2-difliiorocthyl)-2-mcthyl- 1 H-bcnzo|d|imidazol-6-yl)-4-(mcthoxy- ,)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2621] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-(methoxy-ti )-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2622] ; (ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [2623] ; l-(4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [2624] ;

(S)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2625] ;

(R)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2626] ; l-(2-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-7-azaspiro [3.5]nonan-7-yl)ethan- 1 -one [2627] ; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2628]; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2629];

1 -(7 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-benzo [d]imidazol-6-yl)-4-methoxy-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-2-azaspiro [3.5]nonan-2-yl)ethan- 1 -one [2630] ;

5-(l-(2,2-difluoroethyl)-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-N-(l,4- dioxaspiro [4.5] decan-8 -y 1) -7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [2631];

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2632] ;

3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2633] ;

(3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2634];

((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2635];

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)acetamide [2636];

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)acetamide [2637];

N-(( Is, 3s)-3-((5-(l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2638] ; N-(( lr,3r)-3-((5-( l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2639] ;

1 -(( 1 r,3r)-3 -((5 -( 1 -(2,2-difluoroethyl)-4-fluoro-2-methyl- IH-benzo [d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2640] ; l-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)pyrrolidin-2-one [2641];

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2642] ;

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2643] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-l-carboxamide [2644];

(( 1 s,4s)-4-((5 -( 1 -(2, 2-difluoroethyl)-4-fluoro-2 -methyl- IH-benzo [d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2645] ;

N-(( Is, 4s)-4-((5-(l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2646] ;

N-(( lr,4r)-4-((5-( l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2647] ;

1-(( Is, 4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2648];

2-(((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2649] ;

2-(((lr,4r)-4-((5-( l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2650] ;

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)acetamide [2651];

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2652] ;

(lr,4r)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2653] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [2654] ; l-(4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [2655] ; (S)-5-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2656] ;

(R)-5-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2657] ; l-(2-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-7-azaspiro [3.5]nonan-7-yl)ethan- 1 -one [2658] ; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2659]; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2660]; l-(7-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-2-azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [2661] ;

5-(l -(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-N-(2-oxaspiro[3.5]nonan- 7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2662] ;

5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-N-(l,4- dioxaspiro [4.5] decan-8 -y 1) -7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [2663] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l-trimethylcyclobutane-l-carboxamide [2664];

3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2665] ;

((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2666];

(3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2667];

N-(( Is, 3s)-3-((5-(l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2668] ;

N-(( lr,3r)-3-((5-( l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2669] ;

N-(( Is, 3s)-3-((5-(l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2670] ; N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2671] ; l-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2672] ; l-(( Is, 3s)-3-((5-(l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2673] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2674] ;

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2675] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-l-carboxamide [2676];

((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2677];

N-(( Is, 4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2678];

N-(( lr,4r)-4-((5-( l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2679];

1-(( Is, 4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy-

7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2680];

2-(((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-

7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [2681];

2-(((lr,4r)-4-((5-( l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2682] ;

N-(( lr,4r)-4-((5-( l-(2, 2-difluoroethyl)-4-fluoro-2 -methyl- lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexyl)acetamide [2683] ;

(lr,4r)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-(methoxy- <7,)-7H-py rrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2684] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-(methoxy- <7,)-7H-py rrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2685] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [2686] ; l-(4-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [2687] ; (R)-5-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2688] ;

(S)-5-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2689] ; l-(2-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2690] ; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)- yl)ethan-l-one [2691]; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)- yl)ethan-l-one [2692]; l-(7-((5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2-azaspiro [3.5 ]nonan-2-yl)ethan- 1 -one [2693] ;

5-(l-(2,2-difluoroethyl)-4-fluoro-2-methyl-lH-benzo[d]imidazol-6-yl)-4-methoxy-N-(l,4- dioxaspiro [4.5] decan-8 -y 1) -7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [2694] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2695] ;

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2696] ;

((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2697];

(( 1 s,3 s)-3 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2698];

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2699] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2700] ;

N-(3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2701] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2702] ;

1 -(( 1 r,3r)-3 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2703] ; 1 -(( 1 s,3 s)-3 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2704] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2705] ;

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2706] ;

( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [2707] ;

(( 1 s,4s)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2708] ;

N-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2709] ;

N-(( 1 r,4r)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2710];

1 -(( 1 s,4s)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2711];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-((ls,4s)-4- methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2712];

2-(((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [2713];

2-((( 1 r,4r)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2714] ;

N-(( 1 r,4r)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)acetamide [2715];

( 1 r,4r)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2716] ;

( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2717];

( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [2718] ; l-(4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [2719] ;

(S)-5 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2720] ; (R)-5 -((5 -( 1 -(2,2-difluoroethyl)-2-methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-l-methylpiperidin-2-one [2721]; l-(2-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-7-azaspiro [3.5]nonan-7-yl)ethan- 1 -one [2722] ; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2723]; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2724]; l-(7-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-2-azaspiro [3.5]nonan-2-yl)ethan- 1 -one [2725] ;

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(2-oxaspiro[3.5]nonan-7- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2726];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-(l,4-dioxaspiro[4.5]decan- 8-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2727] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l-trimethylcyclobutane-l-carboxamide [2728];

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l-trimethylcyclobutane-l-carboxamide [2729];

((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2730];

(( 1 s,3 s)-3 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2731];

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)acetamide [2732];

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)acetamide [2733];

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2734] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2735] ; l-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2736] ; 1 -(( 1 s,3 s)-3 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)pyrrolidin-2-one [2737];

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2738] ;

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2739] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-l-carboxamide [2740];

((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2741];

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2742] ;

N-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2743] ;

1-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2744];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-((ls,4s)-4- methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2745];

2-(((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2746] ;

2-(((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2747] ;

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexyl)acetamide [2748] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [2749] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-(methoxy-<3G)- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2750] ;

( I r.4r)-4-((5-( l-(2.2-difliiorocthyl)-2-mcthyl- 1 H-imidazo|4.5-b|pyridin-6-yl)-4-(mcthoxy-J,)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2751] ; l-(4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [2752] ;

(S)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2753] ; (R)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2754] ; l-(2-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2755] ; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)- yl)ethan-l-one [2756]; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4- methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)- yl)ethan-l-one [2757];

1 -(7 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyridin-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-l-one [2758];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-(2- oxaspiro [3.5]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2759] ;

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-(l,4- dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2 -amine [2760];

( 1 s,3 s)-3 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2761] ;

(lr,3r)-3-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2762] ;

(( 1 s,3 s)-3 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2763];

((lr,3r)-3-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2764];

N-(( 1 r,3r)-3 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2765] ;

N-(( 1 s,3 s)-3 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2766] ;

N-(3-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2767] ;

N-(( 1 r,3r)-3 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2768] ;

1 -(( 1 r,3r)-3 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2769] ; 1 -(( 1 s,3 s)-3 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2770] ;

(lr,3r)-3-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2771] ;

( 1 s,3 s)-3 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2772] ;

( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [2773] ;

(( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2774] ;

N-(( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2775] ;

N-(( 1 r,4r)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2776] ;

1 -(( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2777];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-((ls,4s)-4- methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2778];

2-((( 1 r,4r)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [2779];

2-((( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2780] ;

N-(( 1 r,4r)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)acetamide [2781];

( 1 r,4r)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2782] ;

( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [2783] ; l-(4-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [2784] ;

(S)-5 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2785] ;

(R)-5 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2786] ; l-(2-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-7-azaspiro [3.5]nonan-7-yl)ethan- 1 -one [2787] ; l-((3aR,5s,6aS)-5-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2788]; l-((3aR,5r,6aS)-5-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2789];

1 -(7 -((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)-2-azaspiro [3.5]nonan-2-yl)ethan- 1 -one [2790] ;

5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-N-(2-oxaspiro [3.5]nonan-7- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2791];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(l,4-dioxaspiro[4.5]decan- 8-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2792] ;

N²-(4,4-difluorocyclohexyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)- N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2793];

(lr,4r)-4-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-l-carboxamide [2794];

(ls,4s)-4-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-l-carboxamide [2795];

((lr,4r)-4-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2796] ;

((ls,4s)-4-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2797] ;

N-(( 1 r,4r)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2798];

N-(( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2799];

1 -(( 1 r,4r)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2800];

1 -(( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2801];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((ls,4s)-4- methoxycyclohexyl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2802]; 5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((ls,4s)-4- (difluoromethoxy)cyclohexyl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2803];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((lr,4r)-4- (difluoromethoxy)cyclohexyl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2804];

(ls,4s)-4-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2805] ;

(lr,4r)-4-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2806] ;

N-(( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)acetamide [2807];

N-(( 1 r,4r)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)acetamide [2808];

1 -(( 1 s,4s)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)pyrrolidin-2- one [2809];

1 -(( 1 r,4r)-4-((5 -(3 -(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5 -b]pyridin-5 -yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)pyrrolidin-2- one [2810];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((3R,4S)-3-fluoro-l- methylpiperidin-4-yl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2811];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((3S,4R)-3-fluoro-l- methylpiperidin-4-yl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2812];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((3S,4S)-3-fluoro-l- methylpiperidin-4-yl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2813];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((3R,4R)-3-fluoro-l- methylpiperidin-4-yl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2814]; l-(7-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-l-one [2815];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N⁴-methyl-N²-(2- oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2816];

(R)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-methoxy-N-( 1,1,1 - trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [2817]; (ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2818] ;

(Ir, 3r)-3-((5-(l-(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2, 3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2819] ;

((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2820];

((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2821 ] ;

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2822] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2823] ;

N-(3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2824] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2825] ;

1 -(( 1 r,3r)-3 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyrazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2826] ; l-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2827] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2828] ;

(Ir, 3r)-3-((5-(l-(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2, 3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2829] ;

( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [2830] ;

((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2831] ;

N-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2832] ;

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2833] ; l-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2834] ; 5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-N-((ls,4s)-4- methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2835];

2-(((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2836] ;

2-(((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2837] ;

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclohexyl)acetamide [2838] ;

( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2839] ;

(Ir, 4r)-4-((5-(l-(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2, 3- d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2840] ;

( 1 s,4s)-4-((5-( 1 -(2, 2-difluoroethyl)-2 -methyl- lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [2841] ; l-(4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [2842] ;

(S)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2843] ;

(R)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [2844] ; l-(2-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-7-azaspiro [3.5]nonan-7-yl)ethan- 1 -one [2845] ; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2846]; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2847];

1 -(7 -((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyrazin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-2-azaspiro [3.5]nonan-2-yl)ethan- 1 -one [2848] ;

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-N-(2-oxaspiro[3.5]nonan-7- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2849];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-N-(l,4-dioxaspiro[4.5]decan- 8-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2850] ;

713 (ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-4-(methylamino)- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-l-carboxamide [2851];

(lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-4-(methylamino)- 7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-l-carboxamide [2852];

((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-4-(methylamino)- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2853] ;

((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-4-(methylamino)- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2854] ;

N-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2855];

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2856]; l-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-4-

(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2857];

1 -(( 1 r,4r)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyrazin-6-yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2858]; l-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)pyrrolidin-2- one [2859];

1 -(( 1 r,4r)-4-((5 -( 1 -(2, 2-difluoroethyl)-2 -methyl- IH-imidazo [4,5 -b]pyrazin-6-yl)-4- (methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)pyrrolidin-2- one [2860];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-N²-((ls,4s)-4- methoxycyclohexyl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2861];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyrazin-6-yl)-N⁴-methyl-N²-(2- oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidine-2,4-diamine [2862] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [2863] ;

(lr,3r)-3-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [2864] ;

((lr,3r)-3-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2865] ;

((ls,3s)-3-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2866] ; N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [2867] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [2868] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [2869] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [2870] ;

1-((lr,3r)-3-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)pyrrolidin-2-one [2871];

1 -(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [2872] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [2873];

(lr,3r)-3-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [2874];

( 1 s,4s)-4-((5-([ 1 ,2,4]triazolo[4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane- 1 -carboxamide [2875] ;

((ls,4s)-4-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2876];

N-(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2877] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2878] ;

1 -(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2879];

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-((ls,4s)-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2880];

2-((( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2881] ;

2-((( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2882] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexyl)acetamide [2883] ; ( 1 r,4r)-4-((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2884];

( 1 s,4s)-4-((5-([ 1 ,2,4]triazolo[4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [2885];

( 1 s,4s)-4-((5-([ 1 ,2,4]triazolo[4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)- 1 - ethylcyclohexan-l-ol [2886];

1 -(4-((5-([ 1 ,2,4]triazolo[4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin- 1 - yl)ethan-l-one [2887];

(R)-5 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2888];

(S)-5 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [2889]; l-(2-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2890] ;

1 -((3aR,5 s,6aS)-5 -((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2891] ; l-((3aR,5r,6aS)-5-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2892] ;

1 -(7 -((5-([ 1 ,2,4]triazolo[4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [2893];

5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-N-(2 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [2894];

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2895];

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2896];

(lr,3r)-3-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [2897];

((ls,3s)-3-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2898] ;

(( 1 r,3r)-3 -((5 -([1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [2899] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [2900] ; N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)acetamide [2901] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2902] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [2903] ;

1 -(( 1 r,3r)-3 -((5 -([1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2904] ;

1 -(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2905] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutan- 1 -ol [2906] ;

(lr,3r)-3-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclobutan- 1 -ol [2907] ;

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) -N,N -dimethylcyclohexane - 1 -carboxamide [2908] ;

((ls,4s)-4-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2909];

N-(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2910] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2911];

1 -(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2912];

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(methoxy-tiG)-N-((ls,4s)-4-methoxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [2913];

2-((( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2914] ;

2-((( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2915] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [2916];

(lr,4r)-4-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2917]; ( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2918];

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -ethylcyclohexan- 1 -ol [2919];

(lr,4r)-4-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(methoxy-<3G)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2920] ;

(ls,4s)-4-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(methoxy-tiG)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [2921]; l-(4-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [2922] ;

(S)-5 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [2923] ;

(R)-5 -((5 -( [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [2924] ; l-(2-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2925] ; l-((3aR,5s,6aS)-5-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2926]; l-((3aR,5r,6aS)-5-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [2927]; l-(7-((5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 2-azaspiro [3.5 ]nonan-2-yl)ethan- 1 -one [2928] ;

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2929];

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2930] ;

(ls,3s)-N,N,l-trimethyl-3-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-y l)amino)cy clobutane - 1 -carboxamide [2931];

(lr,3r)-N,N,l-trimethyl-3-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutane-l -carboxamide [2932];

(( 1 s,3 s)- 1 -methyl-3 -((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-l-yl)methanone [2933];

((lr,3r)-l-methyl-3-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [2934] ; N-((ls,3s)-l-methyl-3-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutyl)acetamide [2935] ;

N-((lr,3r)-l-methyl-3-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutyl)acetamide [2936] ;

N-((ls,3s)-l-methyl-3-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [2937] ;

N-((lr,3r)-l-methyl-3-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [2938] ;

1 -(( 1 r,3r)- 1 -methyl-3 -((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclobutyl)pyrrolidin-2-one [2939] ;

1 -(( 1 s,3 s)- 1 -methyl-3 -((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclobutyl)pyrrolidin-2-one [2940] ;

( 1 s,3 s)- 1 -methyl-3 -((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclobutan- 1 -ol [2941] ;

( 1 r,3r)- 1 -methyl-3 -((5 -(3 -methyl- [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclobutan- 1 -ol [2942] ;

(ls,4s)-N,N-dimethyl-4-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexane- 1 -carboxamide [2943] ;

(( 1 s,4s)-4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [2944];

N-(( 1 s,4s)-4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2945] ;

N-(( 1 r,4r)-4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [2946] ;

1 -(( 1 s,4s)-4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [2947] ;

2-((( 1 s,4s)-4-((5 -(3 -methyl- [ 1 ,2,4]triazolo[4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2948] ;

2-((( 1 r,4r)-4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2949] ;

N-(( 1 r,4r)- 1 -methyl -4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2950] ;

( 1 r,4r)- 1 -methyl-4-((5 -(3 -methyl- [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclohexan- 1 -ol [2951] ; ( 1 s,4s)- 1 -methyl -4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclohexan- 1 -ol [2952] ;

( 1 s,4s)- 1 -ethyl -4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [2953];

1 -(4-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [2954] ;

(S)- 1 -methyl-5 -((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin-2-one [2955];

(R)-l-methyl-5-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)piperidin-2-one [2956];

1 -(2-((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 - azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2957] ;

1 -((3aR,5 s,6aS)-5 -((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2958] ; l-((3aR,5r,6aS)-5-((5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2959] ;

1 -(7 -((5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [2960];

5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [2961];

5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2962] ;

(lr,3r)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2963] ;

( 1 s,3 s)-3 -((4-methoxy-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [2964] ;

((lr,3r)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2965];

((ls,3s)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [2966];

N-((ls,3s)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2967] ;

N-((lr,3r)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [2968] ; N-((ls,3s)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2969] ;

N-((lr,3r)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [2970] ;

1-((lr,3r)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)pyrrolidin-2-one [2971];

1 -(( 1 s,3 s)-3 -((4-methoxy-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [2972] ;

( 1 s,3 s)-3 -((4-methoxy-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2973] ;

(lr,3r)-3-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [2974] ;

(ls,4s)-4-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [2975] ;

((ls,4s)-4-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [2976] ;

N-((ls,4s)-4-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2977] ;

N-(( 1 r,4r)-4-((4-methoxy-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2978] ;

1 -(( 1 s,4s)-4-((4-methoxy-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2979] ;

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-N-((ls,4s)-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2980] ;

2-((( 1 s,4s)-4-((4-methoxy-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [2981];

2-(((lr,4r)-4-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [2982] ;

N-(( 1 r,4r)-4-((4-methoxy-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexyl)acetamide [2983] ;

( 1 r,4r)-4-((4-methoxy-5 -(3 -methyl- [ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2984] ;

(ls,4s)-4-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2985] ; (ls,4s)-l-ethyl-4-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol [2986] ;

(lr,4r)-4-((4-(methoxy-<3G)-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2987] ;

( 1 s,4s)-4-((4-(methoxy-tiG)-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [2988] ; l-(4-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [2989] ;

(S)-5-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [2990] ;

(R)-5-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [2991] ; l-(2-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)-7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [2992] ; l-((3aR,5s,6aS)-5-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2993] ; l-((3aR,5r,6aS)-5-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [2994] ; l-(7-((4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-l-one [2995];

4-methoxy-5 -(3 -methyl-[ 1 ,2,4]triazolo [4,3 -a]pyridin-6-yl)-N-(2-oxaspiro [3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [2996] ;

4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [2997] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [2998] ;

(lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [2999] ;

((lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin-l-yl)methanone [3000]; or a pharmaceutically acceptable salt thereof.

29. The compound according to any one of claims 1-22, wherein the compound of Formula I is selected from the group consisting of: ((ls,3s)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3001] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [3002] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [3003] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [3004] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [3005] ;

1-((lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)pyrrolidin-2-one [3006] ;

1 -(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [3007] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [3008];

(lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [3009];

( 1 s,4s)-4-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane- 1 -carboxamide [3010] ;

(( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [3011];

N-(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3012] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3013] ;

1 -(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3014];

2-((( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3015] ;

2-((( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3016] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexyl)acetamide [3017] ; ( 1 s,4s)-4-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [3018];

( 1 r,4r)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [3019];

( 1 s,4s)-4-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)- 1 - ethylcyclohexan-l-ol [3020];

1 -(4-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin- 1 - yl)ethan-l-one [3021];

(S)-5 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [3022];

(R)-5 -((5 -( [ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [3023];

1 -(2-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3024] ; l-((3aR,5r,6aS)-5-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3025] ;

1 -((3aR,5 s,6aS)-5 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3026] ;

1 -(7 -((5 -( [ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3027];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-N-(2 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [3028];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3029];

(ls,3s)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [3030];

(lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) -N,N, 1 -trimethylcyclobutane - 1 -carboxamide [3031];

(( 1 r,3r)-3 -((5 -([1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3032] ;

((ls,3s)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3033] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [3034] ; N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [3035] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [3036] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [3037] ;

1 -(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3038] ;

1 -(( 1 r,3r)-3 -((5 -([1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3039] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutan- 1 -ol [3040] ;

(lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclobutan- 1 -ol [3041 ] ;

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) -N,N -dimethylcyclohexane - 1 -carboxamide [3042] ;

(( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3043];

N-(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3044] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3045] ;

1 -(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3046] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-N-(( 1 s,4s)-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3047] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a | py ridm-6-yl )-4-(mcthoxy-J,)-N-(( 1 s,4s)-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3048] ;

2-((( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3049] ;

2-((( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3050] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [3051]; ( 1 r,4r)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclohexan- 1 -ol [3052] ;

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3053] ;

( 1 r,4r)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a | py ridi n-6-yl )-4-(mcthoxy-J,)-7H-py rrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3054] ;

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-(methoxy-tiG)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3055] ;

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -ethylcyclohexan- 1 -ol [3056] ;

1 -(4-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [3057] ;

(R)-5 -((5 -( [ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [3058] ;

(S)-5 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [3059] ;

1 -(2-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3060] ;

1 -((3aR,5 s,6aS)-5 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [3061]; l-((3aR,5r,6aS)-5-((5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3062] ;

1 -(7 -((5 -( [ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 2-azaspiro [3.5 ]nonan-2-yl)ethan- 1 -one [3063] ;

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3064];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3065] ;

( 1 s,3 s)-N,N, 1 -trimethyl-3 -((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclobutane-l -carboxamide [3066];

(lr,3r)-N,N,l-trimethyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutane-l -carboxamide [3067];

((lr,3r)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [3068] ; ((ls,3s)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [3069] ;

N-((ls,3s)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutyl)acetamide [3070] ;

N-((lr,3r)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutyl)acetamide [3071];

N-((ls,3s)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [3072] ;

N-((lr,3r)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [3073] ; l-((lr,3r)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)cyclobutyl)pyrrolidin-2-one [3074] ;

1-((ls,3s)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-

2-yl)amino)cyclobutyl)pyrrolidin-2-one [3075] ;

(lr,3r)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclobutan-l-ol [3076];

(ls,3s)-l-methyl-3-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclobutan-l-ol [3077];

(ls,4s)-N,N-dimethyl-4-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexane-l -carboxamide [3078];

(( 1 s,4s)-4-((5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3079];

N-((lr,4r)-4-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3080] ;

N-(( 1 s,4s)-4-((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3081] ;

1 -(( 1 s,4s)-4-((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3082] ;

2-((( 1 s,4s)-4-((5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3083] ;

2-((( 1 r,4r)-4-((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3084] ;

N-((lr,4r)-l-methyl-4-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3085] ; ( 1 r,4r)- 1 -methyl-4-((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3086];

( 1 s,4s)- 1 -ethyl -4-((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3087];

1 -(4-((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [3088] ;

(S)-l-methyl-5-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)piperidin-2-one [3089];

(R)- 1 -methyl-5 -((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin-2-one [3090];

1 -(2 -((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3091]; l-((3aR,5s,6aS)-5-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3092] ; l-((3aR,5r,6aS)-5-((5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3093] ;

1 -(7 -((5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3094];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3095];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3096];

(ls,3s)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [3097] ;

(lr,3r)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [3098] ;

((lr,3r)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3099] ;

((ls,3s)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3100] ;

N-((ls,3s)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [3101] ;

N-((lr,3r)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [3102] ; N-((ls,3s)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [3103] ;

N-((lr,3r)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [3104] ; l-((lr,3r)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3105] ;

1-((ls,3s)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3106] ;

(ls,3s)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino) - 1 -methylcyclobutan- 1 -ol [3107];

(lr,3r)-3-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino) - 1 -methylcyclobutan- 1 -ol [3108];

( 1 s,4s)-4-((4-methoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [3109] ;

((ls,4s)-4-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [3110];

N-(( 1 s,4s)-4-((4-methoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3111];

N-((lr,4r)-4-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3112];

1 -(( 1 s,4s)-4-((4-methoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3113];

4-methoxy-N-((ls,4s)-4-methoxycyclohexyl)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3114];

4-(mcthoxy-J,)-N-(( 1 s,4s)-4-methoxycyclohexyl)-5-( 1 -methyl- lH-benzo[d] [ 1 ,2, 3]triazol-6-yl)- 7H-pyrrolo[2,3-d]pyrimidin-2-amine [3115];

2-((( 1 s,4s)-4-((4-methoxy-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3116];

2-(((lr,4r)-4-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3117];

N-((lr,4r)-4-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)acetamide [3118];

( 1 r,4r)-4-((4-methoxy-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)- 1 -methylcyclohexan- 1 -ol [3119]; ( 1 s,4s)-4-((4-methoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)- 1 -methylcyclohexan- 1 -ol [3120] ;

(lr,4r)-4-((4-(methoxy-<3G)-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-y l)amino)- 1 -methylcyclohexan- 1 -ol [3121];

( 1 s,4s)-4-((4-(methoxy-tiG)-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [3122];

( 1 s,4s)- 1 -ethyl -4-((4-methoxy-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexan-l-ol [3123];

1 -(4-((4-methoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [3124] ;

(R)-5-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [3125] ;

(S)-5-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [3126] ;

N-((lR,5S,6s)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(l-methyl-lH- benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3127];

N-((lR,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol- 6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3128] ;

1 -(2-((4-methoxy-5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) -7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3129]; l-((3aR,5s,6aS)-5-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [3130]; l-((3aR,5r,6aS)-5-((4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [3131];

1 -(7 -((4-methoxy-5 -( 1 -methyl- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) -2 -azaspiro [3.5 ]nonan-2-yl)ethan- 1 -one [3132];

4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3133];

4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3134];

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [3135] ;

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [3136] ;

730 ((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3137] ;

((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3138] ;

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [3139] ;

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [3140] ;

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [3141] ;

N-((lr,3r)-3-((3-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-112-pyrrolo[3,2-c]pyridin- 6-yl)amino)- 1 -methylcyclobutyl)propionamide [3142] ; l-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3143] ;

1-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3144] ;

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino) - 1 -methylcyclobutan- 1 -ol [3145];

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino) - 1 -methylcyclobutan- 1 -ol [3146];

( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [3147] ;

(( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [3148] ;

N-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3149] ;

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3150] ;

1 -(( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3151];

5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-N-(( 1 s,4s)-4-methoxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3152];

2-((( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [3153]; 2-(((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [3154];

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)acetamide [3155];

( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)- 1 -methylcyclohexan- 1 -ol [3156] ;

(lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)- 1 -methylcyclohexan- 1 -ol [3157] ;

( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [3158]; l-(4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [3159] ;

(S)-5 -((5 -( 1 -(2,2-difluoroethyl)- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [3160] ;

(R)-5 -((5 -( 1 -(2,2-difluoroethyl)- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylpiperidin-2-one [3161]; l-(2-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) -7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3162]; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [3163]; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [3164];

1 -(7 -((5 -( 1 -(2,2-difluoroethyl)- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) -2 -azaspiro [3.5 ]nonan-2-yl)ethan- 1 -one [3165];

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3166];

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3167];

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [3168] ;

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N, 1 -trimethylcyclobutane- 1 -carboxamide [3169] ;

((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [3170]; ((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)(pyrrolidin-l-yl)methanone [3171];

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [3172];

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)acetamide [3173];

N-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [3174];

N-((lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)propionamide [3175];

1 -(( 1 r,3r)-3 -((5 -( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3176];

1-((ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclobutyl)pyrrolidin-2-one [3177];

(ls,3s)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [3178];

(lr,3r)-3-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [3179];

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [3180] ;

(( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [3181] ;

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3182];

N-((ls,4s)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3183];

1 -(( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3184];

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-N-((ls,4s)-4- methoxy cyclohexyl) -7H-py rrolo [2,3 -d]pyrimidin-2-amine [3185];

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-(methoxy-d3)-N-((ls,4s)-4- methoxy cyclohexyl) -7H-py rrolo [2,3 -d]pyrimidin-2-amine [3186];

2-((( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [3187];

733 2-(((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-l-ol [3188];

N-((lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexyl)acetamide [3189];

(lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [3190];

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-y l)amino)- 1 -methylcyclohexan- 1 -ol [3191];

(lr,4r)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-(methoxy-<3G)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [3192] ;

( 1 s,4s)-4-((5-( 1 -(2,2-difluoroethyl)- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-4-(methoxy-tiG)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol [3193] ;

(ls,4s)-4-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [3194] ;

1 -(4-((5 -( 1 -(2,2-difluoroethyl)- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-4-methoxy-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one [3195];

(R)-5 -((5 -( 1 -(2,2-difluoroethyl)- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-4-methoxy-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [3196] ;

(S)-5 -((5 -( 1 -(2,2-difluoroethyl)- IH-benzo [d] [ 1 ,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one [3197] ;

1 -(2 -((5 -( 1 -(2,2-difluoroethyl)- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-4-methoxy-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-7-azaspiro [3.5]nonan-7-yl)ethan- 1 -one [3198] ; l-((3aR,5r,6aS)-5-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [3199]; l-((3aR,5s,6aS)-5-((5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-7H- pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(lH)-yl)ethan-l-one [3200];

1 -(7 -((5 -( 1 -(2,2-difluoroethyl)- IH-benzo [d] [ 1 ,2,3 ]triazol-6-yl)-4-methoxy-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)-2-azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3201] ;

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3202];

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan- 8-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [3203] ; ( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [3204] ;

(lr,3r)-3-((5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [3205] ;

(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3206] ;

(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3207] ;

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [3208] ;

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [3209] ;

N-(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)propionamide [3210];

N-(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)propionamide [3211];

1 -(( 1 r,3r)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)pyrrolidin -2 -one [3212] ;

1 -(( 1 s,3 s)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)pyrrolidin -2 -one [3213] ;

( 1 s,3s)-3 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [3214];

(lr,3r)-3-((5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [3215];

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane - 1 -carboxamide [3216];

(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [3217] ;

N-((ls,4s)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3218] ;

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3219] ;

1 -(( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3220] ; 2-((( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3221] ;

2-((( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3222] ;

N-(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexyl)acetamide [3223] ;

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [3224];

(lr,4r)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexan-l-ol [3225];

( 1 s,4s)- 1 -ethyl -4-((5 -(imidazof 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3226];

1 -(4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)piperidin- 1 - yl)ethan-l-one [3227];

(R)-5 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [3228];

(S)-5-((5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylpiperidin-2-one [3229];

1 -(2 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 - azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3230] ;

1 -((3aR,5 s,6aS)-5 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3231] ; l-((3aR,5r,6aS)-5-((5-(imidazo[l,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3232] ;

1 -(7 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3233];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N-(2-oxaspiro [3.5]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [3234];

5-(imidazo[l,2-b]pyridazin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [3235];

N²-(4,4-difluorocyclohexyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴-methyl-7H-pyrrolo[2,3- d]pyrimidine-2,4-diamine [3236];

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [3237] ; (lr,4r)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) -N,N -dimethylcyclohexane - 1 -carboxamide [3238] ;

(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [3239] ;

((ls,4s)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3240];

N-((ls,4s)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3241] ;

N-((lr,4r)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3242] ;

1 -(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3243] ; l-((ls,4s)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3244] ;

5-(imidazo[l,2-b]pyridazin-6-yl)-N²-((ls,4s)-4-methoxycyclohexyl)-N⁴-methyl-7H-pyrrolo[2,3- d]pyrimidine-2,4-diamine [3245];

N²-((ls,4s)-4-(difluoromethoxy)cyclohexyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴-methyl-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3246];

N²-((lr,4r)-4-(difluoromethoxy)cyclohexyl)-5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴-methyl-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3247];

N-((ls,4s)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [3248] ;

N-((lr,4r)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [3249] ; l-((ls,4s)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)pyrrolidin-2-one [3250] ;

1 -(( 1 r,4r)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclohexyl)pyrrolidin-2-one [3251 ] ;

( 1 s,4s)-4-((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3252] ;

(lr,4r)-4-((5-(imidazo[l,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3253] ;

N²-((3R,4S)-3-fluoro-l-methylpiperidin-4-yl)-5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴-methyl-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3254]; N²-((3S,4R)-3-fluoro-l-methylpiperidin-4-yl)-5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴-methyl-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3255];

N²-((3S,4S)-3-fluoro-l-methylpiperidin-4-yl)-5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴-methyl-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3256];

N²-((3R,4R)-3-fluoro-l-methylpiperidin-4-yl)-5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴-methyl-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3257];

1 -(7 -((5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-l-one [3258];

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N⁴ -methyl -N²-(2 -oxaspiro [3.5]nonan-7 -yl)-7H-pyrrolo [2,3 - d]pyrimidine-2,4-diamine [3259];

( 1 s,3 s)-N,N, 1 -trimethyl-3 -((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclobutane- 1 -carboxamide [3260] ;

(lr,3r)-N,N,l-trimethyl-3-((5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclobutane- 1 -carboxamide [3261] ;

((ls,3s)-l-methyl-3-((5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [3262] ;

(( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [3263] ;

N-(( 1 s,3 s)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)acetamide [3264] ;

N-(( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)acetamide [3265] ;

N-(( 1 s,3 s)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)propionamide [3266];

N-(( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)propionamide [3267];

1 -(( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)pyrrolidin -2-one [3268] ;

1 -(( 1 s,3 s)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)pyrrolidin -2-one [3269] ;

( 1 s,3 s)- 1 -methyl-3 -((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutan-l-ol [3270];

( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutan-l-ol [3271]; (ls,4s)-N,N-dimethyl-4-((5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexane- 1 -carboxamide [3272] ;

(( 1 s,4s)-4-((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3273];

N-(( 1 s,4s)-4-((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3274] ;

N-(( 1 r,4r)-4-((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3275] ;

1 -(( 1 s,4s)-4-((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3276];

N-(( 1 r,4r)-4-methoxycyclohexyl)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [3277];

N-((lr,4r)-4-(difluoromethoxy)cyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3278];

2-((( 1 r,4r)-4-((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3279] ;

N-(( 1 r,4r)- 1 -methyl -4-((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3280] ;

( 1 s,4s)- 1 -ethyl -4-((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3281];

1 -(4-((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)piperidin- 1 - yl)ethan-l-one [3282];

(S)- 1 -methyl-5 -((5 -(py razolo| 1.5 -a | py ridin-5 -yl )-7H-py rrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin-2-one [3283];

(R)- 1 -methyl-5 -((5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin-2-one [3284];

1 -(2-((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3285] ;

1 -((3aR,5 s,6aS)-5 -((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3286] ; l-((3aR,5r,6aS)-5-((5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3287] ;

1 -(7 -((5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3288]; 5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-(2 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [3289];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-( 1 ,4-dioxaspiro [4.5 ]decan-8-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- amine [3290];

4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3291] ;

( 1 r,3r)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- N,N, 1 -trimethylcyclobutane - 1 -carboxamide [3292];

( 1 s,3 s)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- N,N, 1 -trimethylcyclobutane - 1 -carboxamide [3293];

(( 1 s,3 s)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3294] ;

(( 1 r,3r)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3295] ;

N-(( 1 s,3 s)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)acetamide [3296] ;

N-(( 1 r,3r)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)acetamide [3297] ;

N-(( 1 s,3 s)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [3298] ;

N-(( 1 r,3r)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclobutyl)propionamide [3299] ;

1 -(( 1 r,3r)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3300] ;

1 -(( 1 s,3 s)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3301] ;

( 1 s,3 s)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1-methylcyclobutan-l-ol [3302];

( 1 r,3r)-3 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1-methylcyclobutan-l-ol [3303];

( 1 s,4s)-4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- N,N -dimethylcyclohexane - 1 -carboxamide [3304] ;

(( 1 s,4s)-4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3305]; N-(( 1 s,4s)-4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3306] ;

N-(( 1 r,4r)-4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3307] ;

1 -(( 1 s,4s)-4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3308] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-N-(( 1 s,4s)-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3309] ;

4-methoxy-N-((lr,4r)-4-methoxycyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3310];

4-(methoxy-<3G)-N-((ls,4s)-4-methoxycyclohexyl)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3311];

N-(( 1 r,4r)-4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [3312];

(lr,4r)-4-((4-(methoxy-d3)-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3313];

( 1 sXs)-4-((4-(mcthoxy-J,)-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3314];

( 1 s,4s)- 1 -ethyl -4-((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3315];

1 -(4-((4-methoxy-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [3316] ;

(S)-5 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [3317];

(R)-5 -((4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [3318];

N-((lR,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3319];

N-((lR,5S,6s)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3320] ;

4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-N-(2-oxaspiro[3.3]heptan-6-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3321];

1 -(2-((4-methoxy-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 - azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3322] ;

741 1 -((3aR,5 s,6aS)-5 -((4-methoxy-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3323] ; l-((3aR,5r,6aS)-5-((4-methoxy-5-(pyrazolo[l,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3324] ;

1 -(7 -((4-methoxy-5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3325];

4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-(2 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [3326];

5-(4-methoxy-2-(((ls,4s)-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- methylpyrazolo [1,5 -a]pyridine -3 -carboxamide [3327] ;

5-(2-(((ls,4s)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5- yl)-N -methylpyrazolo [1,5 -a]pyridine -3 -carboxamide [3328] ;

5-(2-(((lr,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5- yl)-N -methylpyrazolo [1,5 -a]pyridine -3 -carboxamide [3329] ;

5-(2-(((lr,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-(methoxy-<3G)-7H-pyrrolo[2,3- d]pyrimidin-5 -y 1) -N -methylpyrazolo [1,5 -a]pyridine-3 -carboxamide [3330] ;

5-(2-((( l s.4s)-4-hydroxy-4-mcthylcyclohcxyl)amino)-4-(mcthoxy-<7,)-7H-pyrrolo|2.3- d]pyrimidin-5 -y 1) -N -methylpyrazolo [1,5 -a]pyridine-3 -carboxamide [3331];

5-(2-(((ls,4s)-4-ethyl-4-hydroxycyclohexyl)amino)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5- yl)-N -methylpyrazolo [1,5 -a]pyridine -3 -carboxamide [3332] ;

5-(2-((2-oxaspiro[3.5]nonan-7-yl)amino)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- methylpyrazolo [1,5 -a]pyridine -3 -carboxamide [3333] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [3334] ;

(lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [3335] ;

((ls,3s)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3336] ;

((lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3337] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [3338] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [3339] ;

742 N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [3340] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)propionamide [3341];

1-((lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcy clobutyl)pyrrolidin -2 -one [3342] ;

1 -(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clobutyl)pyrrolidin-2 -one [3343] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [3344];

(lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [3345];

( 1 s,4s)-4-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-7-yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane - 1 -carboxamide [3346] ;

(( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3347];

N-(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3348] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3349] ;

1 -(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3350] ;

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-N-((ls,4s)-4-methoxycyclohexyl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3351];

2-((( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3352] ;

2-((( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3353] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcy clohexyl)acetamide [3354] ;

( 1 r,4r)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [3355];

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan-l-ol [3356]; ( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - ethylcyclohexan-l-ol [3357]; l-(4-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-l- yl)ethan-l-one [3358];

(R)-5 -((5 -( [ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [3359];

(S)-5 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [3360]; l-(2-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3361];

1 -((3aR,5 s,6aS)-5 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3362] ; l-((3aR,5r,6aS)-5-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3363] ;

1 -(7 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3364];

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-N-(2 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-amine [3365];

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3366];

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [3367];

(lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)-N,N, 1 -trimethylcyclobutane - 1 -carboxamide [3368];

(( 1 r,3r)-3 -((5 -([1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3369] ;

((ls,3s)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3370] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)acetamide [3371] ;

N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)acetamide [3372] ;

N-(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-l-methylcyclobutyl)propionamide [3373]; N-(( 1 r,3r)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-l-methylcyclobutyl)propionamide [3374];

1 -(( 1 r,3r)-3 -((5 -([1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3375] ;

1 -(( 1 s,3 s)-3 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutyl)pyrrolidin-2-one [3376] ;

( 1 s,3 s)-3 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylcyclobutan- 1 -ol [3377] ;

(lr,3r)-3-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)- 1 -methylcyclobutan- 1 -ol [3378] ;

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [3379] ;

(( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3380];

N-(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3381] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3382] ;

1 -(( 1 s,4s)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3383] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-N-(( 1 s,4s)-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3384] ;

5 -([ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl )-4-(mcthoxy-J,)-N-(( 1 s,4s)-4-methoxycyclohexyl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3385] ;

2-((( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3386] ;

2-((( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3387] ;

N-(( 1 r,4r)-4-((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexyl)acetamide [3388] ;

( 1 r,4r)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3389] ;

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3390] ; (lr,4r)-4-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-(methoxy-<3G)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3391];

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -y I )-4-(mcthoxy-t6)-7H-py rrolo [2,3 -d]pyrimidin-2- yl)amino) - 1 -methylcyclohexan- 1 -ol [3392] ;

( 1 s,4s)-4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -ethylcyclohexan- 1 -ol [3393] ;

1 -(4-((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)piperidin- 1 -yl)ethan- 1 -one [3394] ;

(S)-5 -((5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [3395] ;

(R)-5 -((5 -( [ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo[2,3 -d]pyrimidin-2- yl)amino)- 1 -methylpiperidin-2-one [3396] ;

1 -(2-((5-([ 1 ,2,4]triazolo[ 1 ,5 -a]pyridin-7-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 7 -azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3397] ;

1 -((3aR,5 s,6aS)-5 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo[2,3 - d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3398] ; l-((3aR,5r,6aS)-5-((5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3399] ;

1 -(7 -((5 -([ 1 ,2,4]triazolo [1,5 -a]pyridin-7 -yl)-4-methoxy-7H-pyrrolo[2,3 -d]pyrimidin-2-yl)amino)- 2-azaspiro [3.5 ]nonan-2-yl)ethan- 1 -one [3400] ;

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3401];

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3402] ;

( 1 s,3 s)-N,N, 1 -trimethyl-3 -((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutane- 1 -carboxamide [3403] ;

( 1 r,3r)-N,N, 1 -trimethyl-3 -((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutane- 1 -carboxamide [3404] ;

(( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [3405] ;

((ls,3s)-l-methyl-3-((5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [3406] ;

N-(( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)acetamide [3407] ; N-(( 1 s,3 s)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)acetamide [3408] ;

N-(( 1 s,3 s)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)propionamide [3409];

N-(( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)propionamide [3410];

1 -(( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)pyrrolidin -2-one [3411];

1 -(( 1 s,3 s)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)pyrrolidin -2-one [3412];

( 1 s,3 s)- 1 -methyl-3 -((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutan-l-ol [3413];

( 1 r,3r)- 1 -methyl-3 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutan-l-ol [3414];

(ls,4s)-N,N-dimethyl-4-((5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexane - 1 -carboxamide [3415];

(( 1 s,4s)-4-((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3416];

N-(( 1 s,4s)-4-((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3417];

N-(( 1 r,4r)-4-((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3418] ;

1 -(( 1 s,4s)-4-((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3419];

N-((lr,4r)-4-methoxycyclohexyl)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin- 2-amine [3420];

N-(( 1 r,4r)-4-(difluoromethoxy)cyclohexyl)-5 -(pyrazolof 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [3421];

2-((( 1 r,4r)-4-((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3422] ;

2-((( 1 s,4s)-4-((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3423] ;

N-(( 1 r,4r)- 1 -methyl -4-((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3424] ; ( 1 r,4r)- 1 -methyl-4-((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3425];

( 1 s,4s)- 1 -methyl -4-((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3426];

( 1 s,4s)- 1 -ethyl -4-((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3427];

1 -(4-((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)piperidin- 1 - yl)ethan-l-one [3428];

(S)- 1 -methyl-5 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin-2-one [3429];

(R)- 1 -methyl-5 -((5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)piperidin-2-one [3430];

1 -(2-((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 - azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3431];

1 -((3aR,5 s,6aS)-5 -((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3432] ; l-((3aR,5r,6aS)-5-((5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3433] ;

1 -(7 -((5 -(pyrazolo [1,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3434];

5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [3435];

5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3436];

N²-(4,4-difluorocyclohexyl)-N⁴-methyl-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidine-2,4-diamine [3437];

((ls,4s)-4-((4-(methylamino)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3438];

(( 1 r,4r)-4-((4-(methylamino)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3439];

(ls,4s)-N,N-dimethyl-4-((4-(methylamino)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexane-l -carboxamide [3440];

(lr,4r)-N,N-dimethyl-4-((4-(methylamino)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexane-l -carboxamide [3441]; N-(( 1 s,4s)-4-((4-(methylamino)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclohexyl)acetamide [3442] ;

N-(( 1 r,4r)-4-((4-(methylamino)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3443] ;

1 -(( 1 s,4s)-4-((4-(methylamino)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3444] ;

1 -(( 1 r,4r)-4-((4-(methylamino)-5 -(pyrazolof 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3445] ;

N²-(( 1 s,4s)-4-methoxycyclohexyl)-N⁴-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidine-2,4-diamine [3446];

N²-((ls,4s)-4-(difluoromethoxy)cyclohexyl)-N⁴-methyl-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3447];

N²-(( 1 r,4r)-4-(difluoromethoxy)cyclohexyl)-N⁴-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3448];

N-(( 1 s,4s)- 1 -methyl -4-((4-(methylamino)-5 -(pyrazolof 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3449] ;

N-(( 1 r,4r)- 1 -methyl -4-((4-(methylamino)-5 -(pyrazolof 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3450] ; l-((ls,4s)-l-methyl-4-((4-(methylamino)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3451] ; l-((lr,4r)-l-methyl-4-((4-(methylamino)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3452] ;

(ls,4s)-l-methyl-4-((4-(methylamino)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol [3453] ;

( 1 r,4r)- 1 -methyl-4-((4-(methylamino)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol [3454] ;

N²-((3R,4S)-3 -fluoro- 1 -methylpiperidin-4-yl)-N⁴-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3455];

N²-((3 S,4R)-3 -fluoro- 1 -methylpiperidin-4-yl)-N⁴-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3456];

N²-((3S,4S)-3-fluoro-l-methylpiperidin-4-yl)-N⁴-methyl-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3457];

N²-((3R,4R)-3-fluoro-l-methylpiperidin-4-yl)-N⁴-methyl-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3458]; (2-(4-(methylamino)-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2- azabicyclo [2.2.2] octan-4-yl)methanol [3459] ;

1 -(7 -((4-(methylamino)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-l-one [3460];

N⁴-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-N²-(2 -oxaspiro [3 ,5]nonan-7 -yl)-7H-pyrrolo [2,3 - d]pyrimidine-2,4-diamine [3461];

(ls,3s)-3-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [3462] ;

(lr,3r)-3-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [3463] ;

((lr,3r)-3-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3464] ;

((ls,3s)-3-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3465] ;

N-(( 1 r,3r)-3 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [3466] ;

N-(( 1 s,3 s)-3 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)acetamide [3467] ;

N-(( 1 s,3 s)-3 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [3468] ;

N-(( 1 r,3r)-3 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)propionamide [3469] ;

1 -(( 1 r,3r)-3 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [3470] ;

1 -(( 1 s,3 s)-3 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [3471];

( 1 s,3 s)-3 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [3472];

( 1 r,3r)-3 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclobutan- 1 -ol [3473];

(ls,4s)-4-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane- 1 -carboxamide [3474];

(( 1 s,4s)-4-((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin- 1 - yl)methanone [3475]; N-((ls,4s)-4-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3476];

N-(( 1 r,4r)-4-((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3477];

1 -(( 1 s,4s)-4-((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2- one [3478];

2-((( 1 r,4r)-4-((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 - ol [3479];

2-((( 1 s,4s)-4-((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan- 1 - ol [3480];

N-(( 1 r,4r)-4-((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexyl)acetamide [3481] ;

(ls,4s)-4-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylcyclohexan-l-ol

[3482];

( 1 r,4r)-4-((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylcyclohexan- 1 -ol

[3483];

( 1 s,4s)-4-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol

[3484]; l-(4-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-l-yl)ethan-l-one

[3485];

(S)-5 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one

[3486];

(R)-5 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -methylpiperidin-2-one

[3487];

1 -(2 -((5 -(cinnolin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-7 -azaspiro [3.5]nonan-7 - yl)ethan-l-one [3488]; l-((3aR,5s,6aS)-5-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3489] ; l-((3aR,5r,6aS)-5-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3490] ; l-(7-((5-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2- yl)ethan-l-one [3491];

5 -(cinnolin-6-yl)-N-(2 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2 -amine [3492] ;

5 -(cinnolin-6-yl)-N-( 1 ,4-dioxaspiro [4.5 ]decan-8-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3493] ; ( 1 s,3 s)-3 -((5 -(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [3494] ;

( 1 r,3r)-3 -((5 -(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [3495] ;

((lr,3r)-3-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3496] ;

(( 1 s,3 s)-3 -((5 -(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3497] ;

N-((ls,3s)-3-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)acetamide [3498] ;

N-((lr,3r)-3-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)acetamide [3499] ;

N-((ls,3s)-3-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)propionamide [3500]; or a pharmaceutically acceptable salt thereof.

30. The compound according to any one of claims 1-22, wherein the compound of

Formula I is selected from the group consisting of:

N-((lr,3r)-3-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)propionamide [3501] ;

1 -(( 1 r,3r)-3 -((5 -(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [3502] ; l-((ls,3s)-3-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)pyrrolidin-2-one [3503] ;

(ls,3s)-3-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [3504];

( 1 r,3r)-3 -((5 -(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [3505];

(ls,4s)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane - 1 -carboxamide [3506] ;

((ls,4s)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3507];

N-((ls,4s)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3508] ;

N-((lr,4r)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3509] ; 1-((ls,4s)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3510];

2-(((ls,4s)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3511];

2-(((lr,4r)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3512] ;

N-((lr,4r)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexyl)acetamide [3513] ;

(ls,4s)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexan- 1 -ol [3514];

( 1 r,4r)-4-((5 -(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan- 1 -ol [3515];

( I r.4r)-4-((5-(cinnolin-6-yl)-4-(mcthoxy-<7,)-7H-pyrrolo|2.3-d|pyrimidin-2-yl)amino)-l- methylcyclohexan- 1 -ol [3516];

( 1 s.4s)-4-((5-(cmnol in-6-yl)-4-(mcthoxy-J,)-7H-pyrrolo| 2.3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclohexan- l-ol [3517];

(ls,4s)-4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- ethylcyclohexan-l-ol [3518]; l-(4-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-l-yl)ethan-

1-one [3519];

(R)-5-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylpiperidin-

2-one [3520];

(S)-5-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l-methylpiperidin-

2-one [3521]; l-(2-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3522] ; l-((3aR,5s,6aS)-5-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3523] ; l-((3aR,5r,6aS)-5-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3524] ; l-(7-((5-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3525];

5 -(cinnolin-6-yl)-4-methoxy-N-(2 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3526]; 5-(cinnolin-6-yl)-4-methoxy-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [3527];

( 1 s,3 s)-N,N, 1 -trimethyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutane- 1 -carboxamide [3528] ;

(lr,3r)-N,N,l-trimethyl-3-((5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclobutane- 1 -carboxamide [3529] ;

(( 1 r,3r)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [3530] ;

(( 1 s,3 s)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)(pyrrolidin- 1 -yl)methanone [3531] ;

N-(( 1 s,3 s)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)acetamide [3532] ;

N-(( 1 r,3r)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)acetamide [3533] ;

N-(( 1 s,3 s)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)propionamide [3534];

N-(( 1 r,3r)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)propionamide [3535];

1 -(( 1 r,3r)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)pyrrolidin -2-one [3536] ;

1 -(( 1 s,3 s)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclobutyl)pyrrolidin -2-one [3537] ;

( 1 s,3 s)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclobutan- 1 -ol [3538];

( 1 r,3r)- 1 -methyl-3 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclobutan- 1 -ol [3539];

(ls,4s)-N,N-dimethyl-4-((5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexane- 1 -carboxamide [3540]; pyrrolidin- 1 -yl(( 1 s,4s)-4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)methanone [3541] ;

N-((ls,4s)-4-((5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3542];

N-((lr,4r)-4-((5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide

[3543]; 1 -(( 1 s,4s)-4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin- 2-one [3544];

2-((( 1 r,4r)-4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3545] ;

N-(( 1 r,4r)- 1 -methyl -4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3546] ;

( 1 r,4r)- 1 -methyl-4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol

[3547];

( 1 s,4s)- 1 -ethyl -4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol

[3548];

1 -(4-((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)piperidin- 1 -yl)ethan- 1 -one

[3549];

(S)-l-methyl-5-((5-(quinoxahn-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-2-one

[3550];

(R)-l-methyl-5-((5-(quinoxahn-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-2-one

[3551]; l-(2-((5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7- yl)ethan-l-one [3552]; l-((3aR,5r,6aS)-5-((5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3553] ;

1 -((3aR,5 s,6aS)-5 -((5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3554] ; l-(7-((5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2- yl)ethan-l-one [3555];

5-(quinoxalin-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3556];

5-(quinoxalin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3557];

(lr,3r)-3-((4-methoxy-5-(quinoxahn-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,l- trimethylcyclobutane - 1 -carboxamide [3558] ;

( 1 s,3 s)-3 -((4-methoxy-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)-N,N, 1 - trimethylcyclobutane - 1 -carboxamide [3559] ;

(( 1 s,3 s)-3 -((4-methoxy-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3560] ; (( 1 r,3r)-3 -((4-methoxy-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)(pyrrolidin- 1 -yl)methanone [3561] ;

N-((ls,3s)-3-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)acetamide [3562] ;

N-((lr,3r)-3-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)acetamide [3563] ;

N-((ls,3s)-3-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)propionamide [3564] ;

N-((lr,3r)-3-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutyl)propionamide [3565] ;

1 -(( 1 r,3r)-3 -((4-methoxy-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [3566] ;

1 -(( 1 s,3 s)-3 -((4-methoxy-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutyl)pyrrolidin-2-one [3567] ;

( 1 s,3 s)-3 -((4-methoxy-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylcyclobutan-l-ol [3568];

(lr,3r)-3-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclobutan-l-ol [3569];

(ls,4s)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N- dimethylcyclohexane- 1 -carboxamide [3570] ;

((ls,4s)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [3571] ;

N-((ls,4s)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3572] ;

N-((lr,4r)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3573] ;

1-((ls,4s)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3574];

4-methoxy-N-((ls,4s)-4-methoxycyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [3575];

2-(((ls,4s)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3576] ;

2-(((lr,4r)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)oxy)ethan- 1 -ol [3577] ; N-((lr,4r)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexyl)acetamide [3578] ;

(lr,4r)-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylcyclohexan-l-ol [3579];

( I r.4r)-4-((4-(mcthoxy-J,)-5-(qiiinoxalin-6-yl)-7H-pyrrolo|2.3-d|pyrimidin-2-yl)amino)-l- methylcyclohexan-l-ol [3580];

( lsXs)-4-((4-(mcthoxy-Jj)-5-(qiiinoxalin-6-yl)-7H-pyrrolo|2.3-d|pyrimidin-2-yl)amino)-l- methylcy clohexan- 1 -ol [3581];

(ls,4s)-l-ethyl-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3582]; l-(4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-l- yl)ethan-l-one [3583];

(R)-5 -((4-methoxy-5 -(quinoxalin-6-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 - methylpiperidin-2-one [3584];

(S)-5-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-l- methylpiperidin-2-one [3585]; l-(2-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7- azaspiro [3.5 ]nonan-7 -yl)ethan- 1 -one [3586] ; l-((3aR,5r,6aS)-5-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3587] ; l-((3aR,5s,6aS)-5-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)hexahydrocyclopenta[c]pyrrol-2( lH)-yl)ethan- 1 -one [3588] ; l-(7-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2- azaspiro [3 ,5]nonan-2-yl)ethan- 1 -one [3589];

4-methoxy-5-(quinoxalin-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [3590];

4-methoxy-5-(quinoxalin-6-yl)-N-(l,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- amine [3591];

( 1 s,4s)-N,N-dimethyl-4-((4-(methylamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexane-l -carboxamide [3592];

(lr,4r)-N,N-dimethyl-4-((4-(methylamino)-5-(l,5-naphthyridin-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)cyclohexane-l -carboxamide [3593];

(( 1 s,4s)-4-((4-(methylamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin-l-yl)methanone [3594];

757 ((lr,4r)-4-((4-(methylamino)-5-(l,5-naphthyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)(pyrrolidin- 1 -yl)methanone [3595] ;

N-((ls,4s)-4-((4-(methylamino)-5-(l,5-naphthyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3596] ;

N-(( 1 r,4r)-4-((4-(methylamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)acetamide [3597] ;

1 -(( 1 s,4s)-4-((4-(methylamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3598] ;

1 -(( 1 r,4r)-4-((4-(methylamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin-2- yl)amino)cyclohexyl)pyrrolidin-2-one [3599] ;

N²-((ls,4s)-4-methoxycyclohexyl)-N⁴-methyl-5-(l,5-naphthyridin-2-yl)-7H-pyrrolo[2,3- d]pyrimidine-2,4-diamine [3600];

N-(( 1 s,4s)- 1 -methyl -4-((4-(methylamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclohexyl)acetamide [3601] ;

N-(( 1 r,4r)- 1 -methyl -4-((4-(methylamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclohexyl)acetamide [3602] ;

1 -(( 1 r,4r)- 1 -methyl -4-((4-(methy lamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclohexyl)pyrrolidin-2-one [3603] ;

1 -(( 1 s,4s)- 1 -methyl -4-((4-(methy lamino)-5 -( 1 ,5 -naphthyridin-2-yl)-7H-pyrrolo [2,3 -d]pyrimidin- 2-yl)amino)cyclohexyl)pyrrolidin-2-one [3604] ;

N⁴-methyl-5-(l,5-naphthyridin-2-yl)-N²-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidine-2,4-diamine [3605];

5-(imidazo[l,2-a]pyridin-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3606];

5-(imidazo[l,2-a]pyridin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3607];

5 -(imidazo [ 1 ,2-a]pyridin-6-yl)-4-methoxy-N-((4s,7s)- 1 -oxaspiro [3.5 ]nonan-7 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3608] ;

5-(imidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3609];

5 -(8 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-((4s,7s)- 1 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [3610];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3611]; 5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3612];

5-(8-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3613];

5 -(3 -fluoroimidazo [ 1 ,2-a]pyridin-6-yl)-N-((4s,7s)- 1 -oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [3614];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3615];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3616];

5-(3-fluoroimidazo[l,2-a]pyridin-6-yl)-4-methoxy-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3617] ;

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-((4s,7s)- 1 -oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [3618];

5 -(imidazo [ 1 ,2-a]pyrimidin-6-yl)-N-((4r,7r)- 1 -oxaspiro [3.5]nonan-7 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [3619];

5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3620] ;

5-(imidazo[l,2-a]pyrimidin-6-yl)-4-methoxy-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3621];

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-((4s,7s)-l- oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3622] ;

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-N-((4r,7r)-l- oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3623] ;

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-((4r,7r)-l- oxaspiro [3.5]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3624] ;

5-(l-(2,2-difluoroethyl)-2-methyl-lH-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-((4s,7s)-l- oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3625] ;

(ls,4s)-4-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)- 7H-pyrrolo [2,3 -d]pyrimidin-2-yl)amino)- 1 -ethylcyclohexan- 1 -ol [3626] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((3S,4R)-3-fluoro-l- (oxetan-3-yl)piperidin-4-yl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3627];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N²-((3R,4S)-3-fluoro-l- (oxetan-3-yl)piperidin-4-yl)-N⁴-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3628]; 5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N⁴-methyl-N²-((4s,7s)-l- oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidine-2,4-diamine [3629] ;

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N⁴-methyl-N²-((4r,7r)-l- oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidine-2,4-diamine [3630] ;

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3631];

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3632];

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3633] ;

4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3634];

5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3635] ;

5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3636] ;

5-([l,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3637] ;

4-methoxy-5-(3-methyl-[l,2,4]triazolo[4,3-a]pyridin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3638] ;

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3639];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3640];

5 -( [ 1 ,2,4]triazolo [ 1 ,5 -a]pyridin-6-yl)-4-methoxy-N-((4s,7s)- 1 -oxaspiro [3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidin-2 -amine [3641];

5-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-4-methoxy-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3642] ;

( 1 s,4s)- 1 -methyl -4-((5-( 1 -methyl- lH-benzo[d] [ 1 ,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)amino)cyclohexan-l-ol [3643];

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3644] ;

5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3645] ; 4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3646] ;

4-methoxy-5-(l-methyl-lH-benzo[d][l,2,3]triazol-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3647] ;

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-

7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3648] ;

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)- 7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3649] ;

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-N-((4r,7r)-l- oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3650] ;

5-(l-(2,2-difluoroethyl)-lH-benzo[d][l,2,3]triazol-6-yl)-4-methoxy-N-((4s,7s)-l- oxaspiro [3.5 ]nonan-7 -yl)-7H-pyrrolo [2,3 -d]pyrimidin-2-amine [3651 ] ;

( 1 s,4s)- 1 -ethyl -4-((5 -(imidazof 1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol [3652] ;

N²-((3 S,4R)-3 -fluoro- 1 -(oxetan-3 -yl)piperidin-4-yl)-5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N⁴ -methyl - 7H-pyrrolo [2,3 -d]pyrimidine-2,4-diamine [3653] ;

N²-((3R,4S)-3-fluoro-l-(oxetan-3-yl)piperidin-4-yl)-5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴ -methyl- 7H-pyrrolo [2,3 -d]pyrimidine-2,4-diamine [3654] ;

5 -(imidazo [ 1 ,2-b]pyridazin-6-yl)-N⁴ -methyl -N²-((4s, 7s)- 1 -oxaspiro [3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3655];

5-(imidazo[l,2-b]pyridazin-6-yl)-N⁴-methyl-N²-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3656];

5 -(pyrazolo [1,5 -a]pyridin-5 -yl)-N-((4s,7s)- 1 -oxaspiro [3 ,5]nonan-7-yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-amine [3657];

5-(pyrazolo[l,5-a]pyridin-5-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3658];

4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-((4s,7s)- 1 -oxaspiro [3 ,5]nonan-7 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3659] ;

4-methoxy-5 -(pyrazolo [ 1 ,5 -a]pyridin-5 -yl)-N-((4r,7r)- 1 -oxaspiro [3 ,5]nonan-7 -yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3660] ;

5-(2-(((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- methylpyrazolo [1,5 -a]pyridine -3 -carboxamide [3661];

5-(2-(((4r,7r)-l -oxaspiro [3.5 ]nonan-7-yl)amino) -7H-py rrolo [2, 3 -d] pyrimidin-5 -yl)-N - methylpyrazolo [1,5 -a]pyridine -3 -carboxamide [3662] ;

761 5-(2-(((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)amino)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- N-methylpyrazolo [1,5 -a]pyridine-3 -carboxamide [3663] ;

5-(2-(((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)amino)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N- methylpyrazolo [1,5 -a]pyridine -3 -carboxamide [3664] ;

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3665];

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3666];

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-methoxy-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3667] ;

5-([l,2,4]triazolo[l,5-a]pyridin-7-yl)-4-methoxy-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo [2,3 -d]pyrimidin-2 -amine [3668] ;

( 1 s,4s)- 1 -ethyl -4-((4-(methylamino)-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-7H-pyrrolo [2,3 - d]pyrimidin-2-yl)amino)cyclohexan- 1 -ol [3669] ;

N²-((3 S,4R)-3 -fluoro- 1 -(oxetan-3 -yl)piperidin-4-yl)-N⁴-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 - yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3670];

N²-((3R,4S)-3 -fluoro- 1 -(oxetan-3 -yl)piperidin-4-yl)-N⁴-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 - yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3671];

N⁴-methyl-5-(pyrazolo[l,5-a]pyrimidin-5-yl)-N²-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3672];

N⁴-methyl-5 -(pyrazolo [ 1 ,5 -a]pyrimidin-5 -yl)-N²-((4r,7r)- 1 -oxaspiro [3.5]nonan-7 -yl)-7H- pyrrolo[2,3-d]pyrimidine-2,4-diamine [3673];

5-(quinoxalin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3674];

5-(quinoxalin-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3675];

4-methoxy-5-(quinoxalin-6-yl)-N-((4s,7s)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3676];

4-methoxy-5-(quinoxalin-6-yl)-N-((4r,7r)-l-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3- d]pyrimidin-2-amine [3677]; or a pharmaceutically acceptable salt thereof.

31. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to any one of claims 1-30, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

32. A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound according to any one of claims 1-30, or a pharmaceutically acceptable salt, or a pharmaceutical composition of claim 31.

33. The method of claim 32, wherein the disorder or disease is cancer.

34. The method of claim 32, wherein the disorder or disease is diabetes.

35. The method of claim 32, wherein the disorder or disease is a neurological disorder.

36. The method according to any one of claims 32-33, wherein the cancer is selected from the group consisting of: brain tumors, glioblastoma, ovarian, breast, head and neck squamous cell carcinoma, hepatocellular carcinoma, pancreatic cancer, acute lymphoblastic leukemia, acute megakaryoblastic leukemia, and chronic myeloid leukemia.

37. The method according to any one of claims 32 and 35, wherein the disorder or disease is a neurological disorder, wherein the neurological disorder is selected from the group consisting of: Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, CDKL5 Deficiency Disorder, Down Syndrome, Frontotemporal Dementia with Parkinsonism- 17 (FTDP-17), Lewy body dementia, Parkinson’s Disease, Pick's Disease, and additional diseases with pronounced neurodegeneration such as Autism, Dementia, Epilepsy, Huntington’s Disease, Multiple Sclerosis; diseases and disorders associated with acquired brain injury such as Chronic Traumatic Encephalopathy, Traumatic Brain Injury, Tumor, Stroke, Pick disease, progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, globular glial tauopathies, primary age-related tauopathy, neurofibrillary tangle dementia, chronic traumatic encephalopathy (CTE), frontotemporal lobar degeneration with tau inclusions (FTLD-tau), and aging-related tau astrogliopathy.

38. The method according to any one of claims 32, 35, and 37, wherein the disorder or disease is Alzheimer’s disease.

39. The method according to any one of claims 32-38, wherein the patient is a human.