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Title:
8-AZAPROSTAGLANDIN DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2003/074483
Kind Code:
A1
Abstract:
8-Azaprostaglandin represented by the following general formula (I), pharmacologically acceptable salts thereof or cyclodextrin clathrates of the same: (I) wherein each symbol is as defined in the description. Because of strongly binding to PGE receptor subtype EP2, the compounds represented by the general formula (I) are useful in preventing and/or treating immune diseases, allergic diseases, nerve cell death, paramenia, premature birth, misbirth, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, cirrhosis, shock, nephritis, renal insufficiency, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still’s disease, Kawasaki disease, burn, systemic granuloma, ulcerative colitis, Crohn’s disease, hypercytokinemia at dialysis, multiorgan failure, bone diseases and so on.

Inventors:
TANI KOUSUKE (JP)
KOBAYASHI KAORU (JP)
MARUYAMA TORU (JP)
KAMBE TOHRU (JP)
OGAWA MIKIO (JP)
SHIROYA TSUTOMU (JP)
Application Number:
PCT/JP2003/002478
Publication Date:
September 12, 2003
Filing Date:
March 04, 2003
Export Citation:
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Assignee:
ONO PHARMACEUTICAL CO (JP)
TANI KOUSUKE (JP)
KOBAYASHI KAORU (JP)
MARUYAMA TORU (JP)
KAMBE TOHRU (JP)
OGAWA MIKIO (JP)
SHIROYA TSUTOMU (JP)
International Classes:
A61P1/00; A61P1/16; A61P7/00; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/08; A61P13/12; A61P15/06; A61P15/10; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07D207/26; C07D263/24; C07D405/06; C07D405/12; C07D409/06; C07D409/12; C07D413/06; C07D413/12; C07D417/06; C07D417/12; C07D207/27; (IPC1-7): C07D207/27; C07D409/06; C07D417/06; C07D417/12; C07D413/06; C07D263/24; C07D405/12; C07D409/12; C07D405/06; A61K31/4015; A61K31/4025; A61K31/427; A61K31/421; A61K31/422; A61P1/00; A61P1/16; A61P7/00; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/08; A61P13/12; A61P15/06; A61P15/10; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00
Domestic Patent References:
WO2003009872A12003-02-06
WO2003008377A12003-01-30
WO2002042268A22002-05-30
WO2003007941A12003-01-30
WO2002024647A12002-03-28
Foreign References:
EP0471201A11992-02-19
JP2001233792A2001-08-28
JP2001220357A2001-08-14
JP2001181210A2001-07-03
JPS5273865A1977-06-21
BE849346R1977-06-13
JPS52133975A1977-11-09
BE854268A1977-11-04
EP0572365A21993-12-01
JPS511461A1976-01-08
JPS52142060A1977-11-26
BE852941A1977-09-28
JPS51138671A1976-11-30
BE839761A1976-09-20
JPS51143663A1976-12-10
BE841165A1976-10-27
EP0471201A11992-02-19
JP2001233792A2001-08-28
JP2001220357A2001-08-14
JP2001181210A2001-07-03
Other References:
See also references of EP 1481976A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6, Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)
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