Title:
8-HYDROXYQUINOLINE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/075815
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a cMLCK activator which can enhance myocardial contraction without the need to increase the concentration of calcium in cells. The problem is solved by a cMLCK activator comprising a 8-hydroxyquinoline compound represented by general formula (I) (wherein R1 represents a hydrogen atom or the like; R2 represents R7CO- (wherein R7 represents a C1-6 alkyl group or the like) or the like; R3 represents a hydrogen atom or the like; and R4, R5 and R6 each independently represent a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof, or a solvate of the compound or the pharmaceutically acceptable salt.
Inventors:
TSUKAMOTO OSAMU (JP)
TAKASHIMA SEIJI (JP)
HARUTA JUNICHI (JP)
KANAI TOSHIO (JP)
TAKASHIMA SEIJI (JP)
HARUTA JUNICHI (JP)
KANAI TOSHIO (JP)
Application Number:
PCT/JP2023/036369
Publication Date:
April 11, 2024
Filing Date:
October 05, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K31/47; A61K31/4709; A61K31/473; A61K31/506; A61K31/5377; A61K31/5383; A61P9/00; A61P9/04; C07D215/26; C07D215/28; C07D401/04; C07D401/10; C07D401/12; C07D401/14; C07D405/06; C07D405/12; C07D413/14; C07D417/10; C07D417/12; C07D455/04; C07D471/04; C07D498/08
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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