Title:
8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS
Document Type and Number:
WIPO Patent Application WO/2011/156780
Kind Code:
A3
Abstract:
Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of CNS disorders.
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Inventors:
CAMPBELL DAVID (US)
DURON SERGIO G (US)
VOLLRATH BENEDIKT (US)
WADE WARREN (US)
DURON SERGIO G (US)
VOLLRATH BENEDIKT (US)
WADE WARREN (US)
Application Number:
PCT/US2011/040082
Publication Date:
April 19, 2012
Filing Date:
June 10, 2011
Export Citation:
Assignee:
AFRAXIS INC (US)
CAMPBELL DAVID (US)
DURON SERGIO G (US)
VOLLRATH BENEDIKT (US)
WADE WARREN (US)
CAMPBELL DAVID (US)
DURON SERGIO G (US)
VOLLRATH BENEDIKT (US)
WADE WARREN (US)
International Classes:
C07D471/04; A61K31/496; A61K31/519; A61P25/28; C07D403/10; C07D403/12
Domestic Patent References:
| WO2001055148A1 | 2001-08-02 | |||
| WO1998033798A2 | 1998-08-06 |
Other References:
MANUEL N.M. ET AL.: "Combined Ligand and Structure Based Approaches for Narrowing on the Essential Physicochemical Characteristics for CDK4 Inhibition.", J. CHEM. INF. MODEL., vol. 48, no. 7, 2008, pages 1325 - 1336, XP008158585
CABALLERO J., FERNANDEZ M. ET AL.: "Structural requirements of pyrido[2,3-d]pyrimidin-7-one as CDK4/D inhibitors: 2D autocorrelation, CoMFA and CoMSIA analyses.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 6103 - 6115, XP022700340
See also references of EP 2580216A4
CABALLERO J., FERNANDEZ M. ET AL.: "Structural requirements of pyrido[2,3-d]pyrimidin-7-one as CDK4/D inhibitors: 2D autocorrelation, CoMFA and CoMSIA analyses.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 6103 - 6115, XP022700340
See also references of EP 2580216A4
Attorney, Agent or Firm:
HOSTETLER, Michael, J. et al. (650 Page Mill RoadPalo Alto, CA, US)
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