Title:
8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/090939
Kind Code:
A1
Abstract:
Provided is a 8,9-dihydroimidazole[1,2-a]pyrimido[5,4-e]pyrimidine-5(6H)-ketone compound. In particular, provided is a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, wherein A and R1-R7 are as defined herein. The compound of formula (I) is a Wee1 kinase inhibitor. Therefore, the compound of the present invention can be used to treat diseases caused by abnormal activity of Wee1.
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Inventors:
CAI SUI XIONG (CN)
TIAN YE EDWARD (CN)
TIAN YE EDWARD (CN)
Application Number:
PCT/CN2017/111230
Publication Date:
May 24, 2018
Filing Date:
November 16, 2017
Export Citation:
Assignee:
IMPACT THERAPEUTICS INC (CN)
International Classes:
C07D487/14; A61K31/519; A61P35/00; A61P35/02; C07D471/14
Domestic Patent References:
| WO2005021551A1 | 2005-03-10 | |||
| WO2012161812A1 | 2012-11-29 | |||
| WO2015092431A1 | 2015-06-25 | |||
| WO2012161812A1 | 2012-11-29 | |||
| WO2005021551A1 | 2005-03-10 |
Foreign References:
| US3989816A | 1976-11-02 | |||
| US4444762A | 1984-04-24 |
Other References:
NURSE, P., NATURE, vol. 344, 1990, pages 503 - 508
LINDQVIST, A. ET AL., THE JOURNAL OF CELL BIOLOGY, vol. 185, 2009, pages 193 - 202
MCGOWAN, C.H. ET AL., THE EMBO JOURNAL, vol. 12, 1993, pages 75 - 85
PARKER, L.L. ET AL., SCIENCE, vol. 257, 1992, pages 1955 - 1957
O'CONNELL ET AL., THE EMBO JOURNAL, vol. 16, 1997, pages 545 - 554
STUMPFF, J. ET AL., CURR BIOL, vol. 14, 2004, pages 2143 - 2148
SANCAR, A. ET AL., ANNUAL REVIEW OF BIOCHEMISTRY, vol. 73, 2004, pages 39 - 85
WANG, Y. ET AL., CANCER BIOLOGY & THERAPY, vol. 3, 2004, pages 305 - 313
KARNAK ET AL., CLIN CANCER RES, vol. 20, no. 9, 2014, pages 5085 - 5096
BMC CANCER, vol. 15, 2015, pages 462
J CLIN ONCOL, vol. 33, 2015, pages 3409 - 3415
J CLIN ONCOL, 6 September 2016 (2016-09-06), pages JC0675991
GREENWALD ET AL., J. MED. CHEM., vol. 42, 1999, pages 3657 - 3667
LEVENBERG, K., Q., APPL. MATH., vol. 2, 1944, pages 164 - 168
See also references of EP 3543242A4
LINDQVIST, A. ET AL., THE JOURNAL OF CELL BIOLOGY, vol. 185, 2009, pages 193 - 202
MCGOWAN, C.H. ET AL., THE EMBO JOURNAL, vol. 12, 1993, pages 75 - 85
PARKER, L.L. ET AL., SCIENCE, vol. 257, 1992, pages 1955 - 1957
O'CONNELL ET AL., THE EMBO JOURNAL, vol. 16, 1997, pages 545 - 554
STUMPFF, J. ET AL., CURR BIOL, vol. 14, 2004, pages 2143 - 2148
SANCAR, A. ET AL., ANNUAL REVIEW OF BIOCHEMISTRY, vol. 73, 2004, pages 39 - 85
WANG, Y. ET AL., CANCER BIOLOGY & THERAPY, vol. 3, 2004, pages 305 - 313
KARNAK ET AL., CLIN CANCER RES, vol. 20, no. 9, 2014, pages 5085 - 5096
BMC CANCER, vol. 15, 2015, pages 462
J CLIN ONCOL, vol. 33, 2015, pages 3409 - 3415
J CLIN ONCOL, 6 September 2016 (2016-09-06), pages JC0675991
GREENWALD ET AL., J. MED. CHEM., vol. 42, 1999, pages 3657 - 3667
LEVENBERG, K., Q., APPL. MATH., vol. 2, 1944, pages 164 - 168
See also references of EP 3543242A4
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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