Title:
9-HALOGEN-11(BETA)-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT
Document Type and Number:
WIPO Patent Application WO1992008697
Kind Code:
A3
Abstract:
The invention relates to 9-halogen-11 beta -hydroxy prostaglandin derivatives of formula (I) in which Z is the radical (a) or (b), Hal is an alpha or beta -fixed chlorine or fluorine atom, R<1> is the radical CH2OH or (c), R<2> is a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R<1> is the radical (d), where R<3> is an acid radical or the radical R<2> and R<4> is a cycloalkyl group, and if R<2> is a hydrogen atom, their salts with physiological acceptable bases and their cyclodextrin clathrates, process for producing them and their pharmaceutical use.
Inventors:
BUCHMANN BERND (DE)
SKUBALLA WERNER (DE)
THIERAUCH KARL-HEINZ (DE)
VERHALLEN PETER (DE)
SKUBALLA WERNER (DE)
THIERAUCH KARL-HEINZ (DE)
VERHALLEN PETER (DE)
Application Number:
PCT/DE1991/000881
Publication Date:
July 23, 1992
Filing Date:
November 08, 1991
Export Citation:
Assignee:
SCHERING AG (DE)
International Classes:
A61K31/557; A61K31/5575; A61P1/00; A61P1/04; C07C405/00; (IPC1-7): C07C405/00; A61K31/557
Domestic Patent References:
| WO1989003384A1 | 1989-04-20 |
Foreign References:
| EP0030377A1 | 1981-06-17 | |||
| EP0299914B1 | 1993-04-07 |
Other References:
Prostaglandins, Band 11, Nr. 1, Januar 1976; W.L. MILLER et a.: "Relative biological activity of certain prostaglandis and their enantiomers", Seiten 77-84, siehe Seite 80, Tabelle 1
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