Title:
9-MEMBERED FUSED RING DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2016/159082
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel compound having ACC2 inhibition activity and to provide a pharmaceutical composition containing the compound. Provided are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof. (In formula (I), R1 represents a substituted or unsubstituted fused aromatic heterocyclic group represented by formula (II) (in formula (II), ring B represents a 5-membered ring and ring C represents a 6-membered ring), ring A represents a substituted or unsubstituted nonaromatic carbocyclic ring or the like, -L1- represents -O-(CR6R7)m- or the like, -L2- represents -O-(CR6R7)n- or the like, each R6 independently represents hydrogen or the like, each R7 independently represents hydrogen or the like, each m independently represents an integer of 0, 1, 2, or 3, each n independently represents an integer of 1, 2, or 3, R2 represents a substituted or unsubstituted alkyl, R3 represents hydrogen or a substituted or unsubstituted alkyl, and R4 represents a substituted or unsubstituted alkyl carbonyl or the like).
Inventors:
OHYABU NAOKI (JP)
KURAHASHI KANA (JP)
NISHIURA YUJI (JP)
KATOU MANABU (JP)
MIYAZAKI KEISUKE (JP)
SASAKI YOSHIKAZU (JP)
WADA TOSHIHIRO (JP)
IWATSU MASAFUMI (JP)
KURAHASHI KANA (JP)
NISHIURA YUJI (JP)
KATOU MANABU (JP)
MIYAZAKI KEISUKE (JP)
SASAKI YOSHIKAZU (JP)
WADA TOSHIHIRO (JP)
IWATSU MASAFUMI (JP)
Application Number:
PCT/JP2016/060395
Publication Date:
October 06, 2016
Filing Date:
March 30, 2016
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D235/26; A61K31/4184; A61K31/437; A61K31/4439; A61K31/454; A61K31/506; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P25/02; A61P27/02; A61P31/00; A61P35/00; A61P43/00; C07D235/28; C07D401/04; C07D401/12; C07D403/04; C07D403/12; C07D405/12; C07D471/04; C07D493/04
Domestic Patent References:
| WO2014061693A1 | 2014-04-24 | |||
| WO2013035827A1 | 2013-03-14 | |||
| WO2012173099A1 | 2012-12-20 | |||
| WO2013142369A1 | 2013-09-26 | |||
| WO2010111634A2 | 2010-09-30 | |||
| WO2015056782A1 | 2015-04-23 |
Foreign References:
| JP2013525262A | 2013-06-20 | |||
| JP2013545718A | 2013-12-26 | |||
| JP2012533569A | 2012-12-27 | |||
| US20020156075A1 | 2002-10-24 | |||
| JP2003503402A | 2003-01-28 | |||
| JP2016079168A | 2016-05-16 |
Other References:
See also references of EP 3279187A4
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
Hideaki Yamauchi (JP)
Hideaki Yamauchi (JP)
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