Title:
99MTC-LABELLED ISONITRILE-CONTAINING GLUCOSE DERIVATIVE AND PREPARATION METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2018/227977
Kind Code:
A1
Abstract:
Disclosed are a 99mTc-labelled isonitrile-containing glucose derivative of the structural general formula [99mTc-(CNDG)6]+ and a preparation method and the use. The derivative takes 99mTc+ as a central core, and the isonitrile carbon atom in the CNDG and 99mTc(I) coordinate to form a six-coordinated complex [99mTc-(CNDG)6]+. The [99mTc-(CNDG)6]+ derivative is obtained through the synthesis of the ligand CNDG and the preparation of a CNDG freeze-dried medicine box. The derivative of the present invention has good stability and is easy to prepare, has a high uptake and good retention on a tumour site, has a high tumour/non-target ratio, and is a high-performance new type 99mTc-labelled isonitrile-containing glucose derivative useful for tumour imaging, which is easy to popularize and apply.
Inventors:
ZHANG JUNBO (CN)
ZHANG XURAN (CN)
GAN QIANQIAN (CN)
SHAO XIN (CN)
WANG XUEBIN (CN)
TANG ZHIGANG (CN)
LU JIE (CN)
ZHANG ZHANBIN (CN)
ZHANG XURAN (CN)
GAN QIANQIAN (CN)
SHAO XIN (CN)
WANG XUEBIN (CN)
TANG ZHIGANG (CN)
LU JIE (CN)
ZHANG ZHANBIN (CN)
Application Number:
PCT/CN2018/073950
Publication Date:
December 20, 2018
Filing Date:
January 24, 2018
Export Citation:
Assignee:
BEIJING SHIHONG PHARMACEUTICAL RES CENTER (CN)
International Classes:
C07F13/00; A61K51/04; A61K103/10
Foreign References:
| CN107245087A | 2017-10-13 | |||
| CN102993243A | 2013-03-27 | |||
| CN102146098A | 2011-08-10 | |||
| US4735793A | 1988-04-05 |
Other References:
MIZUNO, Y. ET AL.: "Purification-Free Method for Preparing Technetium-99m-Labeled", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 7, 21 March 2016 (2016-03-21), pages 3331 - 3339, XP055559391
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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