A33 ANTIBODY COMPOSITIONS AND METHODS OF USING THE SAME IN RADIOIMMUNOTHERAPY

Title:

A33 ANTIBODY COMPOSITIONS AND METHODS OF USING THE SAME IN RADIOIMMUNOTHERAPY

Document Type and Number:

WIPO Patent Application WO/2019/060750

Kind Code:

A3

Abstract:

The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to and neutralize the activity of A33 protein. The antibodies of the present technology are useful in methods for detecting and treating an A33 -positive cancer in a subject in need thereof.

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Inventors:

WU ZHIHAO (US)
XU HONG (US)
CHEUNG NAI-KONG (US)

Application Number:

PCT/US2018/052253

Publication Date:

May 16, 2019

Filing Date:

September 21, 2018

Export Citation:

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Assignee:

MEMORIAL SLOAN KETTERING CANCER CENTER (US)

International Classes:

A61K31/555; A61K39/395; A61K45/00; A61K47/54; A61K51/04; A61P35/00

Domestic Patent References:

WO2016130539A2	2016-08-18
WO2016164308A1	2016-10-13
WO2016054005A1	2016-04-07

Foreign References:

US6307026B1	2001-10-23
US20020062009A1	2002-05-23

Other References:

KING ET AL.: "Preparation and Precinical Evaluation of Humanised A33 Immunoconjugates for Radioimmunotherapy", BRITISH JOURNAL OF CANCER, vol. 72, no. 6, 1 December 1995 (1995-12-01), pages 1364 - 1372, XP002911796

Attorney, Agent or Firm:

EWING, James, F. et al. (US)

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