ACID-ADDITION SALT OF Trk-INHIBITING COMPOUND

Title:

ACID-ADDITION SALT OF Trk-INHIBITING COMPOUND

Document Type and Number:

WIPO Patent Application WO/2016/027754

Kind Code:

A1

Abstract:

In order to provide an agent for the prevention and/or treatment of Trk-related diseases, the present invention provides a compound that has selective inhibitory activity on Trk, persistently suppresses NGF vascular hyperpermeability, has no drug interactions, and also has exceptional absorbability and solubility in free bases. The compound of the present invention has selective inhibitory activity on Trk, persistently suppresses NGF vascular hyperpermeability, has no drug interactions, and has exceptional absorbability and solubility in free bases, and is therefore useful as a drug for the prevention and/or treatment of Trk-related diseases.

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Inventors:

TAKEUCHI JUN (JP)
ITADANI SATOSHI (JP)
IKURA MASAHIRO (JP)
HIGASHINO MASATO (JP)
KIJIMA HIDEOMI (JP)
ONO SHIZUKA (JP)
YASUHIRO TETSUYA (JP)
NAGAURA TAKESHI (JP)

Application Number:

PCT/JP2015/072990

Publication Date:

February 25, 2016

Filing Date:

August 17, 2015

Export Citation:

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Assignee:

ONO PHARMACEUTICAL CO (JP)

International Classes:

C07D401/12; A61K31/506; A61K45/00; A61P1/04; A61P11/02; A61P13/02; A61P17/04; A61P17/06; A61P25/02; A61P25/06; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D401/14

Domestic Patent References:

WO2013161919A1	2013-10-31
WO2014129431A1	2014-08-28

Other References: