Title:
AADC POLYNUCLEOTIDES FOR THE TREATMENT OF PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2016/073693
Kind Code:
A3
Abstract:
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.
Inventors:
KOTIN ROBERT (US)
KELLS ADRIAN PHILIP (US)
RAVINA BERNARD (US)
KELLS ADRIAN PHILIP (US)
RAVINA BERNARD (US)
Application Number:
PCT/US2015/059201
Publication Date:
June 30, 2016
Filing Date:
November 05, 2015
Export Citation:
Assignee:
VOYAGER THERAPEUTICS INC (US)
International Classes:
A61K45/06; A61P25/16; C12N15/86
Domestic Patent References:
| WO2000023116A1 | 2000-04-27 | |||
| WO2012109570A1 | 2012-08-16 | |||
| WO2012007458A1 | 2012-01-19 |
Foreign References:
| US20120295960A1 | 2012-11-22 | |||
| US20130195801A1 | 2013-08-01 | |||
| US5538885A | 1996-07-23 | |||
| US7906111B2 | 2011-03-15 | |||
| US7588772B2 | 2009-09-15 | |||
| US20120220648A1 | 2012-08-30 | |||
| US20030096264A1 | 2003-05-22 |
Other References:
MATSUURA, M ET AL.: "Human Herpesvirus 6 Major Immediate Early Promoter Has Strong Activity in T Cells and is Useful for Heterologous Gene Expression.", VIROLOGY JOURNAL., vol. 8, no. 9, 2011, pages 1 - 9, XP021089864
BRUN, L ET AL.: "Clinical and Biochemical Features of Aromatic L-amino Acid Decarboxylase Deficiency.", NEUROLOGY, vol. 75, no. 1, 6 July 2010 (2010-07-06), pages 64 - 71, XP055439930
QUATTROCHI, JJ ET AL.: "Dose-Related Suppression of REM Sleep and PGO Waves by the Serotonin-1 Agonist Eltoprazine.", NEUROPSYCHOPHARMACOLOGY., vol. 8, no. 1, 1993, pages 7 - 13, XP055439931
BRUN, L ET AL.: "Clinical and Biochemical Features of Aromatic L-amino Acid Decarboxylase Deficiency.", NEUROLOGY, vol. 75, no. 1, 6 July 2010 (2010-07-06), pages 64 - 71, XP055439930
QUATTROCHI, JJ ET AL.: "Dose-Related Suppression of REM Sleep and PGO Waves by the Serotonin-1 Agonist Eltoprazine.", NEUROPSYCHOPHARMACOLOGY., vol. 8, no. 1, 1993, pages 7 - 13, XP055439931
Attorney, Agent or Firm:
WARD, Donna T. et al. (PC142A Main Stree, Groton Massachusetts, US)
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