Title:
AAPTAMINE ALKALOID DERIVATIVE, SYNTHESIS METHOD THEREFOR AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2018/129904
Kind Code:
A1
Abstract:
Disclosed are a benzodiazepine alkaloid compound and a pharmaceutically acceptable salt thereof, the structure of the compound being shown in general formula (I). In formula (I), R1, R2 and R3 independently are hydrogen, C1
~4 alkyl or C1
~4 alkanoyl; one from among R4 and R5 is a benzene ring or a substituted benzene ring, while the other is hydrogen, a benzene ring or a substituted benzene ring, wherein a substituent group on the substituted benzene ring is hydroxyl, cyano, amino, halogen, C1
~4 alkyl, C1
~4 alkoxy, C1
~4 alkylamino, C1
~4 alkanoyl or C1
~4 alkoxyacyl. Further disclosed are a method for synthesizing the compound and a use in the preparation of anti-tumor drugs. The compound shown in formula (I) may be used for preparing anti-tumor, especially anti-lung cancer, drugs as well as anti-fungal drugs.
More Like This:
| JP3229298 | WATER-SOLUBLE CAMPTOTHECIN DERIVATIVE |
| WO/2005/113018 | CANCER TREATMENT USING VIRUSES AND CAMPTOTHECINS |
| JP2015063486 | EXTERNAL COMPOSITION |
Inventors:
LIN HOUWEN (CN)
YANG FAN (CN)
YANG FAN (CN)
Application Number:
PCT/CN2017/094852
Publication Date:
July 19, 2018
Filing Date:
July 28, 2017
Export Citation:
Assignee:
RENJI HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE (CN)
International Classes:
A61K31/4745; C07D471/06; A61P31/10; A61P35/00
Foreign References:
| CN103936733A | 2014-07-23 | |||
| CN103936734A | 2014-07-23 | |||
| US20050187240A1 | 2005-08-25 |
Attorney, Agent or Firm:
SHANGHAI SSH INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF: