Title:
AAV VARIANT
Document Type and Number:
WIPO Patent Application WO/2014/103957
Kind Code:
A1
Abstract:
The invention provides: an AAV particle containing an adeno-associated viral (AAV) capsid protein having an amino acid sequence selected from the group consisting of SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 24, and SEQ ID NO: 30 of the sequence listing; a nucleic acid that encodes this capsid protein; DNA containing this nucleic acid; a cell containing this DNA; and a method for producing this cell.
Inventors:
NISHIE TOSHIKAZU (JP)
TAKASHIMA FUYUKO (JP)
ENOKI TATSUJI (JP)
MINENO JUNICHI (JP)
TAKASHIMA FUYUKO (JP)
ENOKI TATSUJI (JP)
MINENO JUNICHI (JP)
Application Number:
PCT/JP2013/084336
Publication Date:
July 03, 2014
Filing Date:
December 20, 2013
Export Citation:
Assignee:
TAKARA BIO INC (JP)
International Classes:
C12N15/09; C07K14/075; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00
Foreign References:
| JP2005512569A | 2005-05-12 |
Other References:
NAUMER, M. ET AL.: "Development and validation of novel AAV2 random libraries displaying peptides of diverse lengths and at diverse capsid positions.", HUM. GENE THER., vol. 23, 2012, pages 492 - 507, XP055255147
MULLER, O. J. ET AL.: "Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors.", NAT. BIOTECHNOL., vol. 21, no. 9, 2003, pages 1040 - 1046, XP002297275
WATERKAMP, D. A. ET AL.: "Isolation of targeted AAV2 vectors from novel virus display libraries.", J. GENE MED., vol. 8, 2006, pages 1307 - 1319, XP002596752
GIROD, A. ET AL.: "Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2.", NAT. MED., vol. 5, no. 9, 1999, pages 1052 - 1056, XP002128040
GRIFMAN, M. ET AL.: "Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids.", MOL. THER., vol. 3, no. 6, 2001, pages 964 - 975, XP002235294
WU, P. ET AL.: "Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism.", J. VIROL., vol. 74, no. 18, 2000, pages 8635 - 8647, XP001028219
GAO ET AL., J. VIROLOGY, vol. 78, 2004, pages 6381 - 6388
ADACHI K. ET AL., GENEN THER. REGUL., vol. 5, 2010, pages 31 - 55
GAO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, no. 18, 2002, pages 11854 - 11859
HUMAN GENE THERAPY, vol. 5, 1994, pages 793 - 801
See also references of EP 2940131A4
MULLER, O. J. ET AL.: "Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors.", NAT. BIOTECHNOL., vol. 21, no. 9, 2003, pages 1040 - 1046, XP002297275
WATERKAMP, D. A. ET AL.: "Isolation of targeted AAV2 vectors from novel virus display libraries.", J. GENE MED., vol. 8, 2006, pages 1307 - 1319, XP002596752
GIROD, A. ET AL.: "Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2.", NAT. MED., vol. 5, no. 9, 1999, pages 1052 - 1056, XP002128040
GRIFMAN, M. ET AL.: "Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids.", MOL. THER., vol. 3, no. 6, 2001, pages 964 - 975, XP002235294
WU, P. ET AL.: "Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism.", J. VIROL., vol. 74, no. 18, 2000, pages 8635 - 8647, XP001028219
GAO ET AL., J. VIROLOGY, vol. 78, 2004, pages 6381 - 6388
ADACHI K. ET AL., GENEN THER. REGUL., vol. 5, 2010, pages 31 - 55
GAO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, no. 18, 2002, pages 11854 - 11859
HUMAN GENE THERAPY, vol. 5, 1994, pages 793 - 801
See also references of EP 2940131A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
Download PDF:
Previous Patent: ADHESIVE MEMO DEVICE
Next Patent: IMAGE FORMING DEVICE AND TONER CONTAINER ATTACHABLE TO AND REMOVABLE FROM IMAGE FORMING DEVICE
Next Patent: IMAGE FORMING DEVICE AND TONER CONTAINER ATTACHABLE TO AND REMOVABLE FROM IMAGE FORMING DEVICE