Title:
AAV VECTORS FOR VASCULAR GENE THERAPY IN CORONARY HEART DISEASE AND PERIPHERAL ISCHAEMIA
Document Type and Number:
WIPO Patent Application WO/2015/158667
Kind Code:
A3
Abstract:
The invention concerns the development of gene therapy for coronary heart disease and peripheral ischaemia in mammals. One embodiment is an adeno-associated virus vector (AAV vector) comprising a first gene that codes for a myocardin-related transkriptionsfactor A (MRTF-A). The invention also concerns a pharmaceutical composition comprising an AAV vector as per the invention and a pharmaceutically acceptable carrier. Methods for producing the claimed vector are also disclosed.
Inventors:
KUPATT CHRISTIAN (DE)
HINKEL RABEA (DE)
HINKEL RABEA (DE)
Application Number:
PCT/EP2015/057987
Publication Date:
February 25, 2016
Filing Date:
April 13, 2015
Export Citation:
Assignee:
KUPATT CHRISTIAN (DE)
HINKEL RABEA (DE)
HINKEL RABEA (DE)
International Classes:
C12N15/86; A61K48/00
Other References:
HINKEL R ET AL: "P596:Therapeutic neovascularization by AAV2/9-based gene transfer of Thymosin B4: results of a preclinical pig study", CARDIOVASCULAR RESEARCH, vol. 93, no. Suppl. 1, 15 March 2012 (2012-03-15), pages S117, XP055202679
HINKEL R ET AL: "MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2", NATURE COMMUNICATIONS, vol. 5, 9 June 2014 (2014-06-09), pages 1 - 9, XP055202593, DOI: 10.1038/ncomms4970
MIKHAILOV A T ET AL: "In Search of Novel Targets for Heart Disease: Myocardin and Myocardin-Related Transcriptional Cofactors", BIOCHEMISTRY RESEARCH INTERNATIONAL, vol. 6, no. 10, 1 January 2012 (2012-01-01), pages 1 - 11, XP055202587, ISSN: 2090-2247, DOI: 10.1161/ATVBAHA.110.218149
KUPATT C ET AL: "Cotransfection of Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Via Recombinant Adeno-Associated Virus Resolves Chronic Ischemic Malperfusion", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 56, no. 5, 27 July 2010 (2010-07-27), pages 414 - 422, XP027160198, ISSN: 0735-1097, [retrieved on 20100720]
HINKEL R ET AL: "MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2", NATURE COMMUNICATIONS, vol. 5, 9 June 2014 (2014-06-09), pages 1 - 9, XP055202593, DOI: 10.1038/ncomms4970
MIKHAILOV A T ET AL: "In Search of Novel Targets for Heart Disease: Myocardin and Myocardin-Related Transcriptional Cofactors", BIOCHEMISTRY RESEARCH INTERNATIONAL, vol. 6, no. 10, 1 January 2012 (2012-01-01), pages 1 - 11, XP055202587, ISSN: 2090-2247, DOI: 10.1161/ATVBAHA.110.218149
KUPATT C ET AL: "Cotransfection of Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Via Recombinant Adeno-Associated Virus Resolves Chronic Ischemic Malperfusion", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 56, no. 5, 27 July 2010 (2010-07-27), pages 414 - 422, XP027160198, ISSN: 0735-1097, [retrieved on 20100720]
Attorney, Agent or Firm:
GRUND, Martin (Postfach 44 05 16, München, DE)
Download PDF: