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Title:
ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2016/192631
Kind Code:
A1
Abstract:
The present invention provides an abietane-type diterpene compound having lipid-lowering activity, a method for preparing same, and use of same. Specifically, the compound has the structure shown in formula I. The definitions of the groups are discussed in the specification. The compound of the present invention has activity of increasing in vivo or in vitro ingestion of low-density lipoprotein, and has a potential to be used as a novel lipid-lowering drug.

Inventors:
YE, Yang (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
WANG, Yiping (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
YAO, Sheng (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
ZHAO, Jing (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
TANG, Chunping (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
XU, Wenwei (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
KE, Changqiang (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
XI, Cong (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
Application Number:
CN2016/084358
Publication Date:
December 08, 2016
Filing Date:
June 01, 2016
Export Citation:
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Assignee:
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (No.555 Zu Chong Zhi Road, Pudong, Shanghai 3, 201203, CN)
International Classes:
C07D493/08; A61K31/366; A61P3/06; C07C43/23; C07C62/32; C07C62/36; C07D303/02; C07D307/77; C07D311/80; C07D317/70; C07D319/14
Foreign References:
CN102295545A2011-12-28
CN105801396A2016-07-27
CN104557823A2015-04-29
CN101633660A2010-01-27
Other References:
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LU , YI ET AL.: "Abietane diterpenes from Callicarpa pedunculata", NATURAL PRODUCT RESEARCH AND DEVELOPMENT, vol. 23, no. 1, 31 January 2011 (2011-01-31), pages 66 - 68
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BURNELL, ROBERT H. ET AL.: "The structures of the nellionols. Synthesis of model abieta-8, 11, 13-trien-7-ones. Synthesis of 5-dehydronellionol trimethyl ether.", CANADIAN JOURNAL OF CHEMISTRY., vol. 62, no. 12, 31 December 1984 (1984-12-31), pages 2822 - 2829, XP055127054
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (Room No.106, Building No.1 Universal High-Tech Plaza,958 Zhen Bei Road, Putuo District, Shanghai 3, 200333, CN)
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