Title:
ABT-199 ADDITION SALT AND CRYSTAL FORM THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/049634
Kind Code:
A1
Abstract:
Crystal forms of an ABT-199 monohydrochloride salt and an ABT-199 dihydrochloride salt, a preparation method thereof, and a pharmaceutical composition thereof are disclosed. In comparison to the conventional ABT-199, the embodiments provide one or more improved properties. The embodiments can be used in preparing a medicine for treating and/or preventing an illness caused by over-expression of one or more anti-cell apoptosis bcl-2 family proteins.
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Inventors:
SHENG XIAOHONG (CN)
SHENG XIAOXIA (CN)
ZHENG JIANFENG (CN)
SHENG XIAOXIA (CN)
ZHENG JIANFENG (CN)
Application Number:
PCT/CN2016/099139
Publication Date:
March 22, 2018
Filing Date:
September 14, 2016
Export Citation:
Assignee:
SOLIPHARMA LLC (CN)
International Classes:
C07D471/04; A61K31/437; A61P35/00; A61P37/00
Domestic Patent References:
| WO2012071336A1 | 2012-05-31 | |||
| WO2016126552A1 | 2016-08-11 |
Foreign References:
| CN104370905A | 2015-02-25 | |||
| US20160113925A1 | 2016-04-28 |
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