Title:
ACANTHOPANAX SENTICOSUS HARMS HOMOGENEOUS POLYSACCHARIDE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/016644
Kind Code:
A1
Abstract:
Disclosed is an Acanthopanax senticosus Harms homogeneous polysaccharide, having a molecular weight of 6.83 × 105Da, and consisting of arabinose, galactose, glucose, mannose and xylose, with the mole percentages of the various monosaccharides sequentially being 16.42%, 32.27%, 40.38%, 7.21% and 3.72%. A method for preparing the Acanthopanax senticosus Harms homogeneous polysaccharide is specifically as follows: crushing Acanthopanax senticosus Harms decoction chips into a powder, extracting the Acanthopanax senticosus Harms crude polysaccharide by means of a water extraction method, then removing proteins from the crude polysaccharide by means of a Sevage deproteinization method, and performing further separation and purification by means of an anion exchange DEAE Fast Flow chromatographic column and a Sephadex G-200 glucan gel column chromatographic column, in order to obtain the Acanthopanax senticosus Harms homogeneous polysaccharide. The Acanthopanax senticosus Harms polysaccharide prepared by means of this method is a homogeneous polysaccharide, has antioxidant and anti-skin aging activity, and can be used for preparing cosmetics and drugs with an anti-skin aging effect.
More Like This:
| JP4260427 | Cosmetic composition |
| JPH06154596 | SALT RESISTANT ABSORBENT AND MANUFACTURE OF THE SAME |
| JPH01193302 | PURIFICATION OF SEED POLYSACCHARIDE |
Inventors:
WANG ENHAN (CN)
CHEN HANKUN (CN)
YE MUYING (CN)
LIN HONGJIA (CN)
CHEN HANKUN (CN)
YE MUYING (CN)
LIN HONGJIA (CN)
Application Number:
PCT/CN2020/109792
Publication Date:
January 27, 2022
Filing Date:
August 18, 2020
Export Citation:
Assignee:
GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD (CN)
International Classes:
C08B37/00; A61K8/73; A61K31/715; A61P17/00; A61Q19/08
Foreign References:
| CN103609937A | 2014-03-05 |
Other References:
KIM, MIN-KYEONG;JIN, YING-SHAN;HEO, SEONG-IL;SHIM, TAE-HEUM;SA, JAE-HOON;WANG, MYEONG-HYEON: "Studies for Component Analysis and Antioxidant Effect, Antimicrobial Activity in Acanthopanax senticosus HARMS", KOREAN JOURNAL OF PHARMACOGNOSY, KOREAN SOCIETY OF PHARMACOGNOSY, KR, vol. 37, no. 3, 30 September 2006 (2006-09-30), KR , pages 151 - 156, XP053013960, ISSN: 0253-3073
RUIZHAN CHEN; ZHIQIANG LIU; JIMIN ZHAO; RUIPING CHEN; FANLEI MENG; MIN ZHANG; WENCHENG GE;: "Antioxidant and immunobiological activity of water-soluble polysaccharide fractions purified from Acanthopanax senticosu", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 127, no. 2, 28 December 2010 (2010-12-28), NL , pages 434 - 440, XP028365634, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2010.12.143
BAI XUE, HU WEN-ZHONG;JIANG AI-LI;LI JING;SONG CHUN-LU: "Research advance on main active substance and pharmacological action of Acanthopanax", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, GAI KAN BIANJIBU , BEIJING, CN, no. 4, 31 December 2016 (2016-12-31), CN , pages 396 - 399, XP055888698, ISSN: 1002-0306, DOI: 10.13386/j.issn1002-0306.2016.06.071
LI LIHONG, LI KAI;LI XIANG-HUI: "Study on the Extraction Technology for Acanthopanax Senticosus Polysaccharide", SILIAO YANJIU - FEED RESEARCH, SILIAO YANJIU ZAZHISHE, CN, no. 6, 31 December 2019 (2019-12-31), CN , pages 93 - 96, XP055888711, ISSN: 1002-2813, DOI: 10.13557/j.cnki.issn1002-2813.2019.06.026
LIU SHUMIN, ZHANG NA : "Modern Ｒesearch Progress of Acanthopanax Senticosus Polysaccharide", INFORMATION ON TRADITIONAL CHINESE MEDICINE, vol. 31, no. 2, 31 March 2014 (2014-03-31), pages 116 - 119, XP055888721, ISSN: 1002-2406, DOI: 10.19656/j.cnki.1002-2406.2014.02.045
XIE XIA, LIU XIANG-QIAN: "Advances in Studies on Polysaccharide from Acanthopanax Miq.Plants", PROCEEDINGS OF THE 3RD CHINA TCM COMMODITY ANNUAL MEETING AND 1ST INTERNATIONAL CONFERENCE ON THE DEVELOPMENT OF PUERARIA LOBATA ROOT INDUSTRY; PROCEEDINGS OF CHINA SOCIETY OF CO, 15 July 2012 (2012-07-15), pages 329 - 336, XP055888735
LU JIANING: "Effects of Acanthopanax Extracts on the Apoptosis and Expression of Bcl-2 and Bax Proteins in Photo-Aged Mice", CHINESE MASTER’S THESES FULL-TEXT DATABASE, MEDICAL AND HEALTH SCIENCES, no. 5, 15 May 2014 (2014-05-15), XP055888739
RUIZHAN CHEN; ZHIQIANG LIU; JIMIN ZHAO; RUIPING CHEN; FANLEI MENG; MIN ZHANG; WENCHENG GE;: "Antioxidant and immunobiological activity of water-soluble polysaccharide fractions purified from Acanthopanax senticosu", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 127, no. 2, 28 December 2010 (2010-12-28), NL , pages 434 - 440, XP028365634, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2010.12.143
BAI XUE, HU WEN-ZHONG;JIANG AI-LI;LI JING;SONG CHUN-LU: "Research advance on main active substance and pharmacological action of Acanthopanax", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, GAI KAN BIANJIBU , BEIJING, CN, no. 4, 31 December 2016 (2016-12-31), CN , pages 396 - 399, XP055888698, ISSN: 1002-0306, DOI: 10.13386/j.issn1002-0306.2016.06.071
LI LIHONG, LI KAI;LI XIANG-HUI: "Study on the Extraction Technology for Acanthopanax Senticosus Polysaccharide", SILIAO YANJIU - FEED RESEARCH, SILIAO YANJIU ZAZHISHE, CN, no. 6, 31 December 2019 (2019-12-31), CN , pages 93 - 96, XP055888711, ISSN: 1002-2813, DOI: 10.13557/j.cnki.issn1002-2813.2019.06.026
LIU SHUMIN, ZHANG NA : "Modern Ｒesearch Progress of Acanthopanax Senticosus Polysaccharide", INFORMATION ON TRADITIONAL CHINESE MEDICINE, vol. 31, no. 2, 31 March 2014 (2014-03-31), pages 116 - 119, XP055888721, ISSN: 1002-2406, DOI: 10.19656/j.cnki.1002-2406.2014.02.045
XIE XIA, LIU XIANG-QIAN: "Advances in Studies on Polysaccharide from Acanthopanax Miq.Plants", PROCEEDINGS OF THE 3RD CHINA TCM COMMODITY ANNUAL MEETING AND 1ST INTERNATIONAL CONFERENCE ON THE DEVELOPMENT OF PUERARIA LOBATA ROOT INDUSTRY; PROCEEDINGS OF CHINA SOCIETY OF CO, 15 July 2012 (2012-07-15), pages 329 - 336, XP055888735
LU JIANING: "Effects of Acanthopanax Extracts on the Apoptosis and Expression of Bcl-2 and Bax Proteins in Photo-Aged Mice", CHINESE MASTER’S THESES FULL-TEXT DATABASE, MEDICAL AND HEALTH SCIENCES, no. 5, 15 May 2014 (2014-05-15), XP055888739
Attorney, Agent or Firm:
RUNWEN PATENT LAW FIRM (CN)
Download PDF: