Title:
ACCUMULATIVE BORON 10 MEDICINE FOR BORON NEUTRON CAPTURE THERAPY FOR SELECTIVELY OR LOCALLY TARGETING TUMOR TISSUES IN SHORT TIME
Document Type and Number:
WIPO Patent Application WO/2019/244954
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a 10B medicine that can be selectively accumulated in tumor tissues at a low dose in a short time, and can be applied to BNCT. The accumulative 10B medicine comprises a compound containing: a peptide capable of selectively binding to tumor vascular endothelial cells; and 10B, wherein the accumulative 10B medicine is administered to a subject suffering from cancer at a dose of 300-600mg per administration, and is accumulated after the administration such that the concentration of 10B in the cancer tissue of the subject becomes 1ppm or higher.
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Inventors:
OHYAMA CHIKARA (JP)
YONEYAMA TOHRU (JP)
HATAKEYAMA SHINGO (JP)
ISHIYAMA SHINTARO (JP)
YONEYAMA TOHRU (JP)
HATAKEYAMA SHINGO (JP)
ISHIYAMA SHINTARO (JP)
Application Number:
PCT/JP2019/024367
Publication Date:
December 26, 2019
Filing Date:
June 19, 2019
Export Citation:
Assignee:
UNIV HIROSAKI (JP)
International Classes:
A61K51/08; A61K38/08; A61K38/10; A61K47/64; A61P35/00; C07K7/06; C07K7/08
Domestic Patent References:
| WO2017026276A1 | 2017-02-16 | |||
| WO2018064683A1 | 2018-04-05 | |||
| WO2018034356A1 | 2018-02-22 |
Foreign References:
| JP2013515745A | 2013-05-09 | |||
| JP2006502993A | 2006-01-26 | |||
| US20120172283A1 | 2012-07-05 | |||
| JP6184101B2 | 2017-08-23 |
Other References:
SHIN-ICHIRO MASUNAGA; SADAAKI KIMURAB; TOMOHIRO HARADAB; KENSUKE OKUDAB; YOSHINORI SAKURAIC; HIROKI TANAKAC; MINORU SUZUKIA; NATSU: "Evaluating the Usefulness of a Novel lOB-Carrier Conjugated With Cyclic RGD Peptide in Boron Neutron Capture Therapy", WORLD JOURNAL OF ONCOLOGY, vol. 3, no. 3, 1 June 2012 (2012-06-01), pages 103 - 112, XP055665370, DOI: 10.4021/wjon477w
MARIA V BACKER , TIMUR I GAYNUTDINOV , VIMAL PATEL , ACHINTYA K BANDYOPADHYAYA , B T S THIRUMAMAGAL , WERNER TJARKS , ROLF F BRATH: "Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature", MOLECULAR CANCER THERAPEUTICS, vol. 4, no. 9, 1 September 2005 (2005-09-01), pages 1423 - 1429, XP008058448, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-05-0161
HATTORI YOSHIHIDE: "Most advancements of boron neutron capture therapy . 4 Development of Boron compounds for BNCT (non official translation )", PET JOURNAL, no. 18, 1 January 2012 (2012-01-01), pages 34 - 36+49, XP009525082, ISSN: 2186-022X
LUDERER MICAH JOHN; DE LA PUENTE PILAR; AZAB ABDEL KAREEM: "Advancements in Tumor Targeting Strategies for Boron Neutron Capture Therapy", PHARMACEUTICAL RESEARCH, vol. 32, no. 9, 2 June 2015 (2015-06-02), pages 2824 - 2836, XP035525934, ISSN: 0724-8741, DOI: 10.1007/s11095-015-1718-y
HATAKEYAMA S; SUGIHARA K; SHIBATA T K; NAKAYAMA J; AKAMA T O; TAMURA N; S-M WONG; BOBKOV A A; TAKANO Y; OHYAMA C; FUKUDA M: "Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 49, 6 December 2011 (2011-12-06), pages 19587 - 19592, XP055040103, ISSN: 0027-8424, DOI: 10.1073/pnas.1105057108
MICHIKO F FUKUDA; SHINO HATAKEYAMA; KAZUHIRO SUGIHARA: "Carbohydrate mimetic peptides as research reagent and therapeutic", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 35, no. 10, 1 January 2012 (2012-01-01), pages 1626 - 1632, XP055665398, ISSN: 0918-6158, DOI: 10.1248/bpb.b12-00395
INKA BROCKHAUSEN : "Glycosyltransferases Methods and protocols ", vol. 1022, 30 November 2013, HUMAN PRESS , ISBN: 978-1-62703-464-7, article SHINGO HATAKEYAMA , TOSHIAKI K SHINATA , YUKI TOBISAWA , CHIKARA OHYAMA , KAZUHIRO SUNGIHARA , MICHIKO N FUKUDA: "Tumor targeting by a carbohydrate ligand-mimicking peptide", pages: 369 - 386, XP009525081, DOI: 10.1007/978-162703-465-4_28
MEZÖ GABOR, HUDECZ FERENC, SZEKERKE MARIA, KAJTAR JUDIT, SARMAY GABRIELLA, GERGELY JANOS, NAGY ZSUZSA, CLEGG: "Synthesis and Characterization of p-Borono-Phenylalanine-Branched Polypeptide-Monoclonal Antibody Ternary Systems for Potential Use in Boron Neutron Capture Therapy (BNCT", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 11, no. 4, 26 October 1996 (1996-10-26), pages 263 - 285, XP009525080, ISSN: 0883-9115, DOI: 10.1177/088391159601100401
GU XIAOBO; CAI GANGMING; ZHANG RONGJUN; JIANG MENGJUN; ZHOU YAOYUAN; PAN DONGHUI; XU YUPING; HUANG HONGBO: "Synthesis and preliminary evaluation of 68Ga-NOTA-IF7 as a tumor imaging agent", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 303, no. 1, 24 August 2014 (2014-08-24), pages 777 - 782, XP035418247, ISSN: 0236-5731, DOI: 10.1007/s10967-014-3459-5
GU XIAOBO; JIANG MENGJUN; PAN DONGHUI; CAI GANGMING; ZHANG RONGJUN; ZHOU YAOYUAN; DING YAMING; ZHU BAO; LIN XIUFENG: "Preliminary evaluation of novel 18F-A1F-N0TA-IF7 as a tumor imaging agent", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 308, no. 3, 14 November 2015 (2015-11-14), pages 851 - 856, XP035921170, ISSN: 0236-5731, DOI: 10.1007/s10967-015-4533-3
PROC NATL ACAD SCI USA., vol. 108, no. 49, 2011, pages 19587 - 19592
OH, P. ET AL., NATURE, vol. 429, 2004, pages 629 - 635
HRUBY ET AL., BIOCHEM J., vol. 268, 1990, pages 249 - 262
"Remington: The Science and Practice of Pharmacy", 1995, MACK PUBLISHING COMPANY
See also references of EP 3811980A4
MARIA V BACKER , TIMUR I GAYNUTDINOV , VIMAL PATEL , ACHINTYA K BANDYOPADHYAYA , B T S THIRUMAMAGAL , WERNER TJARKS , ROLF F BRATH: "Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature", MOLECULAR CANCER THERAPEUTICS, vol. 4, no. 9, 1 September 2005 (2005-09-01), pages 1423 - 1429, XP008058448, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-05-0161
HATTORI YOSHIHIDE: "Most advancements of boron neutron capture therapy . 4 Development of Boron compounds for BNCT (non official translation )", PET JOURNAL, no. 18, 1 January 2012 (2012-01-01), pages 34 - 36+49, XP009525082, ISSN: 2186-022X
LUDERER MICAH JOHN; DE LA PUENTE PILAR; AZAB ABDEL KAREEM: "Advancements in Tumor Targeting Strategies for Boron Neutron Capture Therapy", PHARMACEUTICAL RESEARCH, vol. 32, no. 9, 2 June 2015 (2015-06-02), pages 2824 - 2836, XP035525934, ISSN: 0724-8741, DOI: 10.1007/s11095-015-1718-y
HATAKEYAMA S; SUGIHARA K; SHIBATA T K; NAKAYAMA J; AKAMA T O; TAMURA N; S-M WONG; BOBKOV A A; TAKANO Y; OHYAMA C; FUKUDA M: "Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 49, 6 December 2011 (2011-12-06), pages 19587 - 19592, XP055040103, ISSN: 0027-8424, DOI: 10.1073/pnas.1105057108
MICHIKO F FUKUDA; SHINO HATAKEYAMA; KAZUHIRO SUGIHARA: "Carbohydrate mimetic peptides as research reagent and therapeutic", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 35, no. 10, 1 January 2012 (2012-01-01), pages 1626 - 1632, XP055665398, ISSN: 0918-6158, DOI: 10.1248/bpb.b12-00395
INKA BROCKHAUSEN : "Glycosyltransferases Methods and protocols ", vol. 1022, 30 November 2013, HUMAN PRESS , ISBN: 978-1-62703-464-7, article SHINGO HATAKEYAMA , TOSHIAKI K SHINATA , YUKI TOBISAWA , CHIKARA OHYAMA , KAZUHIRO SUNGIHARA , MICHIKO N FUKUDA: "Tumor targeting by a carbohydrate ligand-mimicking peptide", pages: 369 - 386, XP009525081, DOI: 10.1007/978-162703-465-4_28
MEZÖ GABOR, HUDECZ FERENC, SZEKERKE MARIA, KAJTAR JUDIT, SARMAY GABRIELLA, GERGELY JANOS, NAGY ZSUZSA, CLEGG: "Synthesis and Characterization of p-Borono-Phenylalanine-Branched Polypeptide-Monoclonal Antibody Ternary Systems for Potential Use in Boron Neutron Capture Therapy (BNCT", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 11, no. 4, 26 October 1996 (1996-10-26), pages 263 - 285, XP009525080, ISSN: 0883-9115, DOI: 10.1177/088391159601100401
GU XIAOBO; CAI GANGMING; ZHANG RONGJUN; JIANG MENGJUN; ZHOU YAOYUAN; PAN DONGHUI; XU YUPING; HUANG HONGBO: "Synthesis and preliminary evaluation of 68Ga-NOTA-IF7 as a tumor imaging agent", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 303, no. 1, 24 August 2014 (2014-08-24), pages 777 - 782, XP035418247, ISSN: 0236-5731, DOI: 10.1007/s10967-014-3459-5
GU XIAOBO; JIANG MENGJUN; PAN DONGHUI; CAI GANGMING; ZHANG RONGJUN; ZHOU YAOYUAN; DING YAMING; ZHU BAO; LIN XIUFENG: "Preliminary evaluation of novel 18F-A1F-N0TA-IF7 as a tumor imaging agent", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 308, no. 3, 14 November 2015 (2015-11-14), pages 851 - 856, XP035921170, ISSN: 0236-5731, DOI: 10.1007/s10967-015-4533-3
PROC NATL ACAD SCI USA., vol. 108, no. 49, 2011, pages 19587 - 19592
OH, P. ET AL., NATURE, vol. 429, 2004, pages 629 - 635
HRUBY ET AL., BIOCHEM J., vol. 268, 1990, pages 249 - 262
"Remington: The Science and Practice of Pharmacy", 1995, MACK PUBLISHING COMPANY
See also references of EP 3811980A4
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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