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Title:
ACE-INHIBITORS HAVING ANTIOXIDANT AND NITRICOXID-DONOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO2004050084
Kind Code:
A3
Abstract:
Multifonctional ACE inhibitor compounds are provided, that combine ACE-inhibiting activity with capability to scavenge superoxide and other reactive oxygen species, and that may further function as nitric oxide donors. The compounds are useful for preventing or treating various disorders, including cardiovascular, and diabetes associated disorders.

Inventors:
HAJ-YEHIA ABDULLAH IBRAHIM (IL)
KHAN MOHAMED AMIN (US)
QADRI BASHIR ALI (IL)
Application Number:
PCT/IL2003/001006
Publication Date:
September 30, 2004
Filing Date:
November 27, 2003
Export Citation:
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Assignee:
YISSUM RES DEV CO (IL)
HAJ-YEHIA ABDULLAH IBRAHIM (IL)
KHAN MOHAMED AMIN (US)
QADRI BASHIR ALI (IL)
International Classes:
A61K31/385; A61K31/40; A61K31/401; A61K31/403; A61K31/445; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; C07D207/08; C07D207/16; C07D209/48; C07D339/04; C07D403/12; C07D409/06; C07D409/12; C07K5/02; (IPC1-7): A61K31/385; A61K31/40; A61K31/401; A61K31/403; A61K31/445; A61P9/00; A61P9/04; A61P9/06; A61P9/10; C07D207/08; C07D209/44; C07D403/12; C07D409/06; C07D409/12; C07K5/06
Domestic Patent References:
WO2002034303A12002-05-02
WO1998021193A11998-05-22
WO2000061541A22000-10-19
WO1998042661A11998-10-01
WO1999037616A11999-07-29
Foreign References:
US5025001A1991-06-18
Other References:
JIA LEE ET AL: "The effects of S-nitrosocaptopril on renal filtration and blood pressure in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 354, no. 1, 31 July 1998 (1998-07-31), pages 33 - 41, XP002277634, ISSN: 0014-2999
IWANAGA YOSHITAKA ET AL: "A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive LV dysfunction and improves remodeling in cardiomyopathic hamsters with heart failure.", CIRCULATION, vol. 106, no. 19 Supplement, 5 November 2002 (2002-11-05), Abstracts from Scientific Sessions;Chicago, IL, USA; November 17-20, 2002, pages II - 510, XP009029725, ISSN: 0009-7322 (ISSN print)
VAN DER GIET M ET AL: "Captopril and quinapril reduce reactive oxygen species.", EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol. 32, no. 10, October 2002 (2002-10-01), pages 732 - 737, XP002277635, ISSN: 0014-2972
DJORDJEVIC V B ET AL: "CHANGES OF LIPID PEROXIDES AND ANTIOXIDATIVE FACTORS LEVELS IN BLOOD OF PATIENTS TREATED WITH ACE INHIBITORS", CLINICAL NEPHROLOGY, DUSTRI VERLAG, NUENCHEN-DEISENHOFEN, DE, vol. 47, no. 4, April 1997 (1997-04-01), pages 243 - 247, XP001104974, ISSN: 0301-0430
ARUOMA O I ET AL: "EVALUATION OF THE ABILITY OF THE ANGIOTENSIN-CONVERTING ENZYME INHIBITOR CAPTOPRIL TO SCAVENGE REACTIVE OXYGEN SPECIES", CHEMICO-BIOLOGICAL INTERACTIONS, vol. 77, no. 3, 1991, pages 303 - 314, XP002277636, ISSN: 0009-2797
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