Title:
ACETAMINOPHEN-CONTAINING ANALGESIC FORMULATIONS WITH REDUCED HEPATOTOXICITY
Document Type and Number:
WIPO Patent Application WO/2016/025897
Kind Code:
A8
Abstract:
An analgesic composition is provided which is safe and effective to patients requiring pain modulation. The analgesic composition contains (a) acetaminophen and (b) at least three components chosen from (i) a bioavailable oral opioid; (ii) a non-steroidal anti-inflammatory drug; (iii) a sulfur-containing, N-acetyl-p-benzoquinone imine scavenging agent or prodrug thereof; or (iv) an agent which lowers acetaminophen toxicity. These analgesic compositions inhibit the formation or reduce the presence of NAPQI, the toxic acetaminophen by-product responsible for liver toxicity in patients. These analgesic compositions are also safely tolerated by patients administering more than the maximum dosage of acetaminophen.
Inventors:
WRIGHT IV CURTIS (US)
Application Number:
PCT/US2015/045379
Publication Date:
September 22, 2016
Filing Date:
August 14, 2015
Export Citation:
Assignee:
PURDUE PHARMA LP (US)
International Classes:
A61K45/06; A61K31/145; A61K31/167; A61K31/192; A61K31/198; A61K31/4164; A61K31/485; A61K31/616; A61K38/06; A61P25/04; A61P29/00
Attorney, Agent or Firm:
COVERT, John, M. et al. (Kessler Goldstein & Fox, P.L.L.C.,1100 New York Avenue, N, Washington DC, US)
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