ACETAMINOPHEN PREPARATION, AND METHOD FOR PRODUCING SAME

Title:

ACETAMINOPHEN PREPARATION, AND METHOD FOR PRODUCING SAME

Document Type and Number:

WIPO Patent Application WO/2019/093434

Kind Code:

A1

Abstract:

The present invention addresses the problem of providing: a preparation containing acetaminophen at a high content, particularly size-reduced tablets (generally conventional tablets, sustained release tablets, or the like) having excellent elution properties, hardness and uniformity in drug content distribution; and a method for producing the preparation. The present invention provides: a preparation using acetaminophen having specified particle diameters; and a method for producing the preparation. According to the present invention, the fluidability of acetaminophen can be improved, and therefore the secondary coagulation of acetaminophen can be prevented, the production efficiency can be improved, and the cost can be reduced. Accordingly, the preparation and the method are very useful as an acetaminophen preparation having improved ingestability including reduced sizes and a method for producing the acetaminophen preparation, respectively.

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Inventors:

SAKAMOTO HIROSHI (JP)
KOMAI KUNIO (JP)
SAKAKIBARA KENJI (JP)
BANBA HIROKAZU (JP)
FUKUDA KIYOSHI (JP)

Application Number:

PCT/JP2018/041539

Publication Date:

May 16, 2019

Filing Date:

November 08, 2018

Export Citation:

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Assignee:

NIPPON ZOKI PHARMACEUTICAL CO (JP)

International Classes:

A61K31/167; A61K9/20; A61K47/04; A61K47/32; A61K47/38; A61P29/00

Domestic Patent References:

WO2000054752A1

2000-09-21

Foreign References:

JP2002060338A	2002-02-26
JP2013216610A	2013-10-24
JP2010506412W
JP2003081876A	2003-03-19

Other References:

TERASHITA, KEIJIRO ET AL.: "Preparation of Antipyretic Analgesic by Direct Compression and Its Evaluation", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 50, no. 12, December 2002 (2002-12-01), pages 1542 - 1549, XP055608909
See also references of EP 3708157A4

Attorney, Agent or Firm:

FUJII, Ikuro (JP)

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