Title:
ACETATE COMPLEXES AND METHODS FOR ACETATE QUANTIFICATION
Document Type and Number:
WIPO Patent Application WO/2017/066070
Kind Code:
A3
Abstract:
The present invention is directed to methods of acetate quantification and acetate complexes useful in the methods of acetate quantification. Such methods and complexes are useful for any application where acetate quantification is desired, including measuring of concentration of 13C hyperpolarized acetate for imaging agent quality control in MRI and NMR spectroscopy. The disclosed acetate complexes may be prepared from acetate, Fe3+, and sulfosalicylic acid and from acetate, Fe3+, and salicylic acid.
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Inventors:
LEACH ANDREW (US)
CHEN RUI (US)
PALACIOS MANUEL (US)
CHEN RUI (US)
PALACIOS MANUEL (US)
Application Number:
PCT/US2016/055673
Publication Date:
February 22, 2018
Filing Date:
October 06, 2016
Export Citation:
Assignee:
GEN ELECTRIC (US)
International Classes:
C07F15/02; A61K49/06
Domestic Patent References:
| WO1991003200A1 | 1991-03-21 |
Foreign References:
| US20100092391A1 | 2010-04-15 | |||
| US4035239A | 1977-07-12 |
Other References:
POZDNYAKOV, I. P. ET AL.: "Photochemistry of Fe (III) and sulfosalicylic acid aqueous solutions", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A: CHEMISTRY, vol. 182, no. 1, 2006, pages 75 - 81, XP028008396
OGAWA, K. ET AL.: "A spectrophotometric study of the complex formation between iron (III) and sulfosalicylic acid", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 39, no. 2, 1966, pages 223 - 227, XP055526930
OGAWA, K. ET AL.: "A spectrophotometric study of the complex formation between iron (III) and sulfosalicylic acid", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 39, no. 2, 1966, pages 223 - 227, XP055526930
Attorney, Agent or Firm:
BAXTER, William et al. (US)
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