Title:
ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON VASCULAR ENDOTHELIAL LIPASE
Document Type and Number:
WIPO Patent Application WO/2010/044441
Kind Code:
A1
Abstract:
Disclosed is a compound useful as a vascular endothelial lipase inhibitor.
Specifically disclosed is a pharmaceutical composition having an inhibitory activity on vascular endothelial lipase, which comprises a compound represented by formula (I), a pharmaceutically acceptable salt of the compound, or a solvate of the compound or the pharmaceutically acceptable salt.
The substituents contained in formula (I) are as defined in the description of the present application.
Inventors:
MASUDA KOUJI (JP)
KIDA SHIRO (JP)
HAYASHI KYOHEI (JP)
KATOU MANABU (JP)
YOSHIKAWA NAOKI (JP)
KUGIMIYA AKIRA (JP)
NAKAJIMA MADO (JP)
TANAKA NOBUYUKI (JP)
KIDA SHIRO (JP)
HAYASHI KYOHEI (JP)
KATOU MANABU (JP)
YOSHIKAWA NAOKI (JP)
KUGIMIYA AKIRA (JP)
NAKAJIMA MADO (JP)
TANAKA NOBUYUKI (JP)
Application Number:
PCT/JP2009/067845
Publication Date:
April 22, 2010
Filing Date:
October 15, 2009
Export Citation:
Assignee:
SHIONOGI & CO (JP)
MASUDA KOUJI (JP)
KIDA SHIRO (JP)
HAYASHI KYOHEI (JP)
KATOU MANABU (JP)
YOSHIKAWA NAOKI (JP)
KUGIMIYA AKIRA (JP)
NAKAJIMA MADO (JP)
TANAKA NOBUYUKI (JP)
MASUDA KOUJI (JP)
KIDA SHIRO (JP)
HAYASHI KYOHEI (JP)
KATOU MANABU (JP)
YOSHIKAWA NAOKI (JP)
KUGIMIYA AKIRA (JP)
NAKAJIMA MADO (JP)
TANAKA NOBUYUKI (JP)
International Classes:
C07D235/16; A61K31/4184; A61K31/423; A61K31/428; A61K31/429; A61K31/437; A61K31/4439; A61K31/4709; A61K31/496; A61K31/506; A61K31/5377; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07D263/56; C07D277/64; C07D417/04; C07D417/12; C07D513/04
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Other References:
MOUSTAFA HASSAN M. ET AL.: "Studies on organophosphorus compounds: synthesis and reactions of [1, 2, 4, 3] triaza-phospholo[4, 5- a]quinoxaline derivative", HETEROATOM CHEMISTRY, vol. 19, no. 5, 2008, pages 520 - 529, XP008147281
YAKOUT EL-SAYED M. A. ET AL.: "Simple syntheses of benzothiazol-2-ylazoles", HETEROATOM CHEMISTRY, vol. 10, no. 3, 1999, pages 177 - 182, XP008147283
See also references of EP 2351744A4
TCM, vol. 14, no. 5, 2004, pages 202 - 206
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 43, 22 October 2004 (2004-10-22), pages 45085 - 45092
YAKOUT EL-SAYED M. A. ET AL.: "Simple syntheses of benzothiazol-2-ylazoles", HETEROATOM CHEMISTRY, vol. 10, no. 3, 1999, pages 177 - 182, XP008147283
See also references of EP 2351744A4
TCM, vol. 14, no. 5, 2004, pages 202 - 206
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 43, 22 October 2004 (2004-10-22), pages 45085 - 45092
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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