Title:
ACETYLCHOLINESTERASE-DERIVED PEPTIDES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2000073427
Kind Code:
A3
Abstract:
The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and/or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals. Further, the invention relates to antibodies against the peptides, inter alia for diagnostic use, for example, the diagnosis of stress-induced male infertility.
Inventors:
SOREQ HERMONA (IL)
ELDOR AMIRAM (IL)
DEUTCH VARDA (IL)
GRISARU DAN (IL)
ELDOR AMIRAM (IL)
DEUTCH VARDA (IL)
GRISARU DAN (IL)
Application Number:
PCT/IL2000/000311
Publication Date:
February 22, 2001
Filing Date:
May 31, 2000
Export Citation:
Assignee:
YISSUM RES DEV CO (IL)
SOREQ HERMONA (IL)
ELDOR AMIRAM (IL)
DEUTCH VARDA (IL)
GRISARU DAN (IL)
SOREQ HERMONA (IL)
ELDOR AMIRAM (IL)
DEUTCH VARDA (IL)
GRISARU DAN (IL)
International Classes:
C07K16/40; C12N9/18; A61K38/00; (IPC1-7): C12N9/18; A61K38/46; C07K16/40
Domestic Patent References:
| WO1998022132A1 | 1998-05-28 | |||
| WO1991008302A1 | 1991-06-13 |
Other References:
DEUTSCH A. ET AL.: "ARP - a novel hematopoietic growth factor and stress signal derived from acetylcholinesterase", BLOOD, vol. 94, 15 November 1999 (1999-11-15), pages 46A (Abstract 193, poster session 193-I), XP000946381
IBRAHIM M.A.R. & GAAL J.: "Effects of seminal plasma cholinesterase on the viability and freezing properties of bull spermatozoa.", ACTA VETERINARIA ACADEMIAE SCIENTIARUM HUNGARICAE, vol. 27, 1979, pages 403 - 408, XP000961014
PEDRON N.: "Cholinesterase activity of seminal plasma and human spermatozoa in normal and infertile subjects", ARCH. ANDROL., vol. 10, no. 3, 1980, pages 249 - 251, XP000961023
PAULUS J.-M. ET AL.: "Mouse megakaryocyte secrete acetyl cholin esterase EC3.1.1.7", BLOOD, vol. 58, 1981, pages 1100 - 1106, XP002153505
STERNFELD M. ET AL.: "Acetylcholinesterase enhances neurite growth and synapse development throuh alternative contributions of its hydrolitic capacity, core protein, and variable C termini.", J. NEUROSCI., vol. 18, no. 4, 15 February 1998 (1998-02-15), pages 1240 - 1249, XP002148089
IBRAHIM M.A.R. & GAAL J.: "Effects of seminal plasma cholinesterase on the viability and freezing properties of bull spermatozoa.", ACTA VETERINARIA ACADEMIAE SCIENTIARUM HUNGARICAE, vol. 27, 1979, pages 403 - 408, XP000961014
PEDRON N.: "Cholinesterase activity of seminal plasma and human spermatozoa in normal and infertile subjects", ARCH. ANDROL., vol. 10, no. 3, 1980, pages 249 - 251, XP000961023
PAULUS J.-M. ET AL.: "Mouse megakaryocyte secrete acetyl cholin esterase EC3.1.1.7", BLOOD, vol. 58, 1981, pages 1100 - 1106, XP002153505
STERNFELD M. ET AL.: "Acetylcholinesterase enhances neurite growth and synapse development throuh alternative contributions of its hydrolitic capacity, core protein, and variable C termini.", J. NEUROSCI., vol. 18, no. 4, 15 February 1998 (1998-02-15), pages 1240 - 1249, XP002148089
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