ACETYLENE DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREFOR

WIPO Patent Application WO/2012/091115

A1

A novel compound with a uric acid generation inhibiting action is provided. The present invention pertains to an acetylene derivative indicated in formula (I), a prodrug thereof, or a salt of same, that has a xanthine oxidase inhibitory activity and is useful as a prophylactic or therapeutic agent for diseases caused by an abnormal serum urate level. In formula (I): R1 is a hydrogen atom, a C1-6 alkyl, or a C3-8 cycloalkyl, etc.; M is a C6-10 aryl or 5- or 6-membered cyclic heteroaryl; Q is carboxy, etc.; Y independently represents a hydroxyl group or a C1-12 alkyl, etc.; and n is 1 or 2. The group represented by -W-M is a group etc., represented by formula (A), wherein: T is cyano, etc.; and R2 is a hydrogen atom, a fluorine atom, a C1-6 alkyl, or a C1-6 alkoxy, etc.

TAKIGAWA, Yasushi (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)
滝川　靖 (〒04 長野県安曇野市穂高柏原４３６５－１　キッセイ薬品工業株式会社中央研究所内 Nagano, 〒3998304, JP)
ONDA, Yusuke (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)

JP2011/080462

July 05, 2012

December 28, 2011

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Kissei Pharmaceutical Co., Ltd (19-48, Yoshino Matsumoto-sh, Nagano 10, 〒3998710, JP)
キッセイ薬品工業株式会社 (〒10 長野県松本市芳野１９番４８号 Nagano, 〒3998710, JP)
TAKIGAWA, Yasushi (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 〒3998304, JP)
滝川　靖 (〒04 長野県安曇野市穂高柏原４３６５－１　キッセイ薬品工業株式会社中央研究所内 Nagano, 〒3998304, JP)

C07C255/57; A61K31/277; A61K31/381; A61K31/426; A61K31/427; A61K31/44; A61P13/12; A61P19/06; A61P43/00; C07D213/79; C07D277/20; C07D277/56; C07D333/38; C07D417/04

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