ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS

Title:

ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2000044710

Kind Code:

A3

Abstract:

Hydroxamic acids having formula (B) wherein the variables are as defined herein, are useful in treating disease conditions mediated by TNF- alpha such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

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Inventors:

LEVIN JEREMY IAN (US)
CHEN JAMES MING (US)

Application Number:

PCT/US2000/002076

Publication Date:

December 21, 2000

Filing Date:

January 27, 2000

Export Citation:

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Assignee:

AMERICAN CYANAMID CO (US)

International Classes:

C07D295/08; A61K31/18; A61K31/351; A61K31/40; A61K31/4409; A61K31/495; A61P1/00; A61P1/02; A61P1/04; A61P1/16; A61P5/50; A61P7/02; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P13/12; A61P17/02; A61P17/16; A61P19/00; A61P19/02; A61P19/08; A61P25/04; A61P25/28; A61P27/02; A61P27/10; A61P29/00; A61P31/18; A61P35/04; A61P37/06; A61P43/00; C07C303/40; C07C309/42; C07C309/87; C07C311/00; C07C311/29; C07D213/68; C07D295/12; C07D309/12; C07F9/36

Domestic Patent References:

WO1998016503A2	1998-04-23
WO1998008853A1	1998-03-05

Other References:

DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002142178

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